Hydatidiform mole (HM) is rare in postmenopause, with only 7 cases reported. The occurrence of ectopic HM is also rare, with 26 fully documented tubal cases. We are not aware of any reported cases of ectopic HM in a postmenopausal patient. In a 51-year-old patient with 3 years amenorrhea, surgery revealed a necrotic, hemorrhagic mass involving the right peritubal space. Microscopically, chorionic villi were seen within the hemorrhagic mass accompanied by circumferential trophoblast hyperplasia. Immunohistochemically, p57kip2 positive nuclei were prominent in the extravillous (intermediate) trophoblast. The HER2 FISH expression was diploid, consistent with the diagnosis of an early complete HM.
GarciaMRomagueraRLGomez-FernandezC. A hydatidiform mole in a postmenopausal woman. A case report and review of the literature. Arch Pathol Lab Med. 2004;128:1039-1042.
2.
TaskinSCengizBOrtacF. Invasive mole in a postmenopausal woman. Int J Gynaecol Obstet. 2006;93:156-157.
3.
RabczynskiJKochmanAPrudlakELewandowskiM. Hydatidiform mole in 59-years-old woman: a case report. Ginekol Pol. 2000;71:152-154.
4.
AbikeFTemizkanOPayasliAAvsarFKarahanNBaspinarS. Postmenopausal complete hydatidiform mole: a case report. Maturitas. 2008;59:95-98.
5.
CamuzcuogluHToyHCamuzcuogluAOzalpSS. Complete mole hydatidiform in a postmenopausal woman. Eur J Obstet Gynecol Reprod Biol. 2009;142:85-86.
6.
delaFouchardiereACassignolABenkiranLRudigozRCGougeonADevouassoux-ShisheboranM. Invasive hydatiform mole in a postmenopausal woman. Ann Pathol. 2003;23:443-446.
7.
MehrotraSSinghUChauhanS. Molar pregnancy in postmenopausal women: a rare phenomenon. BMJ Case Rep. 2012;2012. doi:10.1136/bcr-2012-006213.
8.
HatanakaKHigashiMFujibayashiM. A case of complete hydatidiform mole in a perimenopausal woman with diagnostic usefulness of p57(kip2) immunohistochemistry and HER2 fluorescent in situ hybridization. Pathol Res Pract. 2012;208:118-120.
9.
SebireNJLindsayIFisherRASavagePSecklMJ. Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies. Int J Gynecol Pathol. 2005;24:260-264.
10.
HassadiaAKewFMTidyJAWellsMHancockBW. Ectopic gestational trophoblastic disease: a case series review. J Reprod Med. 2012;57:297-300.
11.
Cortes-CharryRSalazarAGarcia-BarriolaVDabedPFigueiraLMMaestaI. Hydatidiform mole in ectopic pregnancy: clinical, imaging, pathological and immunohistochemical characteristics. J Reprod Med. 2012;57:329-332.
12.
LeGalloRDStelowEBRamirezNCAtkinsKA. Diagnosis of hydatidiform moles using p57 immunohistochemistry and HER2 fluorescent in situ hybridization. Am J Clin Pathol. 2008;129:749-755.
13.
BurtonJLLidburyEAGillespieAM. Over-diagnosis of hydatidiform mole in early tubal ectopic pregnancy. Histopathology. 2001;38:409-417.
14.
SebireNJ. Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications. Fetal Pediatr Pathol. 2010;29:1-16
15.
RonnettBMDeScipioCMurphyKM. Hydatidiform moles: ancillary techniques to refine diagnosis. Int J Gynecol Pathol. 2011;30:101-116.
16.
LunaDVDulceyINogalesFF. Coexistence of placental site nodule and cervical squamous carcinoma in a 72 year old woman. Int J Gynecol Pathol. 2013;32:335-337.
