Peritoneal keratin granulomatosis is a rare tumor-like lesion caused by deposition of tumor-produced keratin. It may be associated with endometrial or ovarian endometrioid adenocarcinoma, atypical polypoid adenomyoma of the endometrium, or ruptured mature teratomas of the ovary. We present 2 cases of peritoneal keratin granulomatosis associated with FIGO (International Federation of Gynecology and Obstetrics) stage 1 endometrial adenocarcinoma. This entity can mimic advanced-stage disease clinically and radiologically, as it did in those cases, and constitutes a diagnostic pitfall that pathologists and surgeons must be aware.
ClementPB.Reactive tumor-like lesions of the peritoneum. Am J Clin Pathol. 1995;103:673-676.
2.
KimKRScullyRE.Peritoneal keratin granulomas with carcinomas of endometrium and ovary and atypical polypoid adenomyoma of endometrium. A clinicopathological analysis of 22 cases. Am J Surg Pathol. 1990;14:925-932.
3.
UeharaKYasudaMIchimuraT, et al. Peritoneal keratin granuloma associated with endometrioid adenocarcinoma of the uterine corpus. Diagn Pathol. 2011;6:104.
4.
ChenKTKostichNDRosaiJ.Peritoneal foreign body granulomas to keratin in uterine adenocanthoma. Arch Pathol Lab Med. 1978;102:174-177.
5.
de Freitas Pina FerreiraDFernandesDAmaroTPetizA. Extensive peritoneal keratin granuloma in stage IV B endometrial carcinoma with an outstanding survival: a case report and review of the literature. Gynecol Oncol Case Rep. 2012;2:61-62.
