The visual cortex is one of the favorite models for the study of experience-dependent changes in neuronal structure and function. A number of recent investigations indicate that the neurotrophic factors of the nerve growth factor family (neurotrophins) play a pivotal role in visual cortical plasticity. Neurotrophins and their receptors are present in the cortex during the critical period for plasticity, and neurotrophin levels are regulated by electrical activity. Neurotrophins modulate synaptic transmission and patterns of neuronal connectivity in the cortex. This review summarizes the in vivo and in vitro data that demonstrate the involvement of neurotrophins in visual cortical plasticity and discusses the possible mechanisms of their action.
Allendoerfer KL, Cabelli RJ, Escandon E, Kaplan DR, Nikolics K, Shatz CJ. 1994. Regulation of neurotrophin receptors during the maturation of the mammalian visual system. J Neurosci14:1795-1811.
2.
Altar CA, Cai N, Bliven T, Juhasz M, Conner JM, Acheson AL, and others. 1997. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature389:856-860.
3.
Bear MF, Rittenhouse CD. 1999. Molecular basis for induction of ocular dominance plasticity. J Neurobiol41:83-91.
4.
Bear MF, Singer W. 1986. Modulation of visual cortical plasticity by acetylcholine and noradrenaline. Nature320:172-176.
5.
Berardi N, Cellerino A, Domenici L, Fagiolini M, Pizzorusso T, Cattaneo A, and others. 1994. Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system. Proc Natl Acad Sci U S A91:684-688.
6.
Berardi N, Maffei L. 1999. From visual experience to visual function: roles of neurotrophins. J Neurobiol41:119-126.
7.
Berardi N, Pizzorusso T, Maffei L. 2000. Critical periods during sensory development. Curr Opin Neurobiol10:138-145.
8.
Blöchl A, Thoenen H. 1995. Characterization of nerve growth factor (NGF) release from hippocampal neurons: evidence for a constitutive and an unconventional sodium-dependent regulated pathway. Eur J Neurosci7:1220-1228.
9.
Boeshore KL, Luckey CN, Zigmond RE, Large TH. 1999. TrkB isoforms with distinct neurotrophin specificities are expressed in predominantly nonoverlapping populations of avian dorsal root ganglion neurons. J Neurosci19:4739-4747.
10.
Bonhoeffer T. 1996. Neurotrophins and activity-dependent development of the neocortex. Curr Opin Neurobiol6:119-126.
Bozzi Y, Borrelli E. 1999. Absence of the dopamine D2 receptor leads to a decreased expression of GDNF and NT-4 mRNAs in restricted brain areas. Eur J Neurosci11:1275-1284.
13.
Bozzi Y, Pizzorusso T, Cremisi F, Rossi FM, Barsacchi G, Maffei L. 1995. Monocular deprivation decreases the expression of messenger RNA for brain-derived neurothophic factor in the rat visual cortex. Neuroscience69:1133-1144.
14.
Cabelli RJ, Hohn A, Shatz CJ. 1995. Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF. Science267:1662-1666.
15.
Cabelli RJ, Shelton DL, Segal RA, Shatz CJ. 1997. Blockade of endogenous ligands of TrkB inhibits formation of ocular dominance columns. Neuron19:63-76.
16.
Caleo M, Lodovichi C, Maffei L. 1999. Effects of nerve growth factor on visual cortical plasticity require afferent electrical activity. Eur J Neurosci11:2979-2984.
17.
Caleo M, Menna E, Chierzi S, Cenni MC, Maffei L. 2000. Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system. Curr Biol10:1155-1161.
18.
Carmignoto G, Canella R, Candeo P, Comelli MC, Maffei L. 1993. Effects of nerve growth factor on neuronal plasticity of the kitten visual cortex. J Physiol464:343-360.
19.
Carmignoto G, Pizzorusso T, Tia S, Vicini S. 1997. Brain-derived neurotrophic factor and nerve growth factor potentiate excitatory synaptic transmission in the rat visual cortex. J Physiol498(1):153-164.
20.
Castrén E, Zafra F, Thoenen H, Lindholm D. 1992. Light regulates expression of brain-derived neurotrophic factor mRNA in the rat visual cortex. Proc Natl Acad Sci U S A89:9444-9448.
21.
Cellerino A, Maffei L. 1996. The action of neurotrophins in the development and plasticity of the visual cortex. Prog Neurobiol49:53-71.
22.
Domenici L, Cellerino A, Maffei L. 1993. Monocular deprivation effects in the rat visual cortex and lateral geniculate nucleus are prevented by nerve growth factor (NGF): II. Lateral geniculate nucleus. Proc R Soc Lond B Biol Sci251:25-31.
23.
Domenici L, Fontanesi G, Cattaneo A, Bagnoli P, Maffei L. 1995. Nerve growth factor (NGF) uptake and trasport following injection in the developing rat visual cortex. Vis Neurosci11:1093-1102.
24.
Fagiolini M, Pizzorusso T, Berardi N, Domenici L, Maffei L. 1994. Functional postnatal development of the rat primary visual cortex and the role of visual experience: dark-rearing and monocular deprivation. Vision Res34:709-720.
25.
Fawcett JP, Alonso-Vanegas MA, Morris SJ, Miller FD, Sadikot AF, Murphy RA. 2000. Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum. J Neurosci20:274-282.
26.
Fiorentini A, Berardi N, Maffei L. 1995. Nerve growth factor preserves behavioral visual acuity in monocularly deprived kittens. Vis Neurosci12:51-55.
27.
Galuske RAW, Kim D-S, Castrén E, Singer W. 2000. Differential effects of neurotrophins on ocular dominance plasticity in developing and adult cat visual cortex. Eur J Neurosci12:3315-3330.
28.
Garofalo L, Ribeiro da Silva A, Cuello AC. 1992. Nerve-growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals. Proc Natl Acad Sci U S A89:2639-2643.
29.
Ghosh A. 1996. Cortical development: with an eye on neurotrophins. Curr Biol6:130-133.
30.
Gibbs RB, Pfaff DW. 1994. In situ hybridization detection of trkA mRNA in brain: distribution, colocalization with p75NGFR and up-regulation by nerve growth factor. J Comp Neurol341:324-339.
31.
Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, and others. 1996. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Mol Cell Neurosci7:222-238.
32.
Gu Q, Liu Y, Cynader MS. 1994. Nerve growth factor-induced ocular dominance plasticity in adult cat visual cortex. Proc Natl Acad Sci U S A91:8408-8412.
33.
Hata Y, Ohshima M, Ichisaka S, Wakita M, Fukuda M, Tsumoto T. 2000. Brain-derived neurotrophic factor expands ocular dominance columns in visual cortex in monocularly deprived and nondeprived kittens but does not in adult cats. J Neurosci20:RC57.
34.
Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SF. 1998. Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science282:1504-1508.
35.
Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, and others. 1999. BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell98:739-755.
36.
Hubel DH, Wiesel TN. 1962. Receptive fields, binocular interaction and functional architecture in the cat’s visual cortex. J Physiol160:106-154.
37.
Johnson JE, Forbes ME, Ma YT, Hsieh T, Frost DO. 1998. Visual experience alters trafficking of BDNF in the visual cortex. Soc Neurosci Abstr24:22.6.
38.
Jones KR, Farinas I, Backus C, Reichardt LF. 1994. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell76:989-999.
39.
Kafitz KW, Rose CR, Thoenen H, Konnerth A. 1999. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature401:918-921.
40.
Katz LC, Shatz CJ. 1996. Synaptic activity and the construction of cortical circuits. Science274:1133-1138.
41.
Kinoshita S, Yasuda H, Taniguchi N, Katoh-Semba R, Hatanaka H, Tsumoto T. 1999. Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex. J Neurosci19:2122-2130.
42.
Levine ES, Dreyfus CF, Black IB, Plummer MR. 1995. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proc Natl Acad Sci U S A92:8074-8077.
43.
Lewin GR, Barde Y-A. 1996. Physiology of the neurotrophins. Annu Rev Neurosci19:289-317.
44.
Lodovichi C, Berardi N, Pizzorusso T, Maffei L. 2000. Effects of neurotrophins on cortical plasticity: same or different? J Neurosci20:2155-2165.
45.
Maffei L, Berardi N, Domenici L, Parisi V, Pizzorusso T. 1992. Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats. J Neurosci12:4651-4662.
46.
McAllister AK, Katz LC, Lo DC. 1996. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron17:1057-1064.
47.
McAllister AK, Katz LC, Lo DC. 1999. Neurotrophins and synaptic plasticity. Annu Rev Neurosci22:295-318.
48.
McAllister AK, Lo DC, Katz LC. 1995. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron15:791-803.
49.
Minichiello L, Casagranda F, Tatche RS, Stucky CL, Postigo A, Lewin GR, and others. 1998. Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron21:335-345.
50.
Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L. 2000. Blocking the NGF-TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: role of the cholinergic system. Neuron25:165-175.
51.
Pizzorusso T, Berardi N, Rossi FM, Viegi A, Venstrom K, Reichardt LF, and others. 1999. TrkA activation in the rat visual cortex by anti-rat TrkA IgG prevents the effect of monocular deprivation. Eur J Neurosci11:204-212.
52.
Pizzorusso T, Porciatti V, Tseng JL, Aebischer P, Maffei L. 1997. Transplant of polymer-encapsulated cells genetically engineered to release nerve growth factor allows a normal functional development of the visual cortex in dark-reared rats. Neuroscience80:307-311.
53.
Reiter HO, Stryker MP. 1988. Neural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited. Proc Natl Acad Sci U S A85:3623-3627.
54.
Riddle DR, Lo DC, Katz LC. 1995. NT-4 mediated rescuse of lateral geniculate neurons from effects of monocular deprivation. Nature378:189-191.
Sala R, Viegi A, Rossi FM, Pizzorusso T, Bonanno G, Raiteri M, and others. 1998. Nerve growth factor and brain-derived neurotrophic factor increase neurotransmitter release in the rat visual cortex. Eur J Neurosci10:2185-2191.
57.
Schoups AA, Elliott RC, Friedman WJ, Black IB. 1995. NGF and BNDF are differentially modulated by visual experience in the developing geniculocortical pathway. Dev Brain Res86:326-334.
58.
Sherman SM, Spear PD. 1982. Organization of visual pathways in normal and visually deprived cats. Physiol Rev62:738-855.
59.
Thoenen H. 1995. Neurotrophins and neuronal plasticity. Science270:593-598.
60.
Turrigiano G, Nelson SB. 2000. Hebb and homeostasis in neuronal plasticity. Curr Opin Neurobiol10:358-364.
61.
von Bartheld CS, Butowt R. 2000. Expression of neurotrophin-3 (NT-3) and anterograde axonal transport of endogenous NT-3 by retinal ganglion cells in chick embryos. J Neurosci20:736-748.
