Psychostimulants,L-type Calcium Channels,Kinases,and Phosphatases

Abstract

There is growing evidence for the role of voltage-gated L-type Ca²⁺ channels in mediating aspects of the addictive properties of psychostimulants. L-type Ca²⁺ channels activate Ca²⁺ second-messenger pathways that regulate protein phosphorylation and thereby activation of target gene expression. Here the authors will review recent progress in our understanding of L-type Ca²⁺ channel-activated signal transduction pathways that contribute to molecular neuroadaptations evident following acute and chronic exposures to psychostimulants.

Keywords

Drug addiction Cav1.2 Cav1.3 Ventral tegmental area Nucleus accumbens Striatum Phosphorylation

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