Tyrosine kinase inhibitor induced pancreatitis

Abstract

Sorafenib and sunitinib are oral tyrosine kinase inhibitors, commonly used in the treatment of metastatic renal cell carcinoma. Known adverse events associated with tyrosine kinase inhibitors include hypertension and palmarplantar erythrodysesthesia. We report two cases of acute pancreatitis associated with tyrosine kinase inhibitors.

Keywords

Pancreatitis tyrosine kinase inhibitor sunitinib sorafenib

Get full access to this article

View all access options for this article.

References

Whitcomb

. Acute pancreatitis. N Engl J Med 2006; 354: 2142–2150.

VanWoerkom

Adler

. Acute pancreatitis: review and clinical update. Hosp Physician 2009; 45: 9–19.

Morgan

Tillett

Braybrooke

. Management of uncommon chemotherapy-induced emergencies. Lancet Oncol 2011; 12: 806–814.

Nitsche

Jamieson

Lerch

. Drug induced pancreatitis. Best Pract Res Gastroenterol 2010; 24: 143–155.

Spanier

Tuynman

van der Hulst

. Acute pancreatitis and concomitant use of pancreatitis associated drugs. Am J Gastroenterol 2011; 106: 2183–2188.

Pezzili

Fabbri

Imbrogno

. Tyrosine kinase inhibitors, pancreatic hyperenzymemia and acute pancreatitis: a review. Recent Pat Inflamm Allergy Drug Discov 2011; 5: 165–168.

Pezzelli

Corinaldesi

Moriselli-Labate

. Tyrosine kinase inhibitors and acute pancreatitis. JOP 2010; 11: 291–293.

Strumberg

Richly

Hilger

. Phase I clinical and pharmacokinetic study of the novel raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005; 23: 965–972.

Britten

Kabbinavar

Hecht

. A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother Pharmacol 2008; 61: 515–524.

10.

Amar

Tan

. Sorafenib-induced pancreatitis. Mayo Clin Proc 2007; 82: 516–522.

11.

Srinivas

. Acute pancreatitis associated with sorafenib. South Med J 2007; 100: 909–911.

12.

Saadati

Wasif Saif

. Sorafenib-induced acute pancreatitis. J Pancreas 2010; 11: 283–284.

13.

Kobayashi

Kanemitu

Kamoto

. Painless acute pancreatitis associated with sorafenib treatment: a case report. Med Oncol 2011; 28: 463–465.

14.

Ruinemans

Balemans

Wiersma-van Tillburg

. Letter to the editor: fatal necrotizing pancreatitis during combined treatment with erlotinib and sunitinib. Lung Cancer 2010; 70: 364–365.

15.

Naranjo

Busto

Sellers

. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239–245.