Influence of Vasodilator Drugs on Perioperative Blood Pressure

Survey results are given of the incidence and the etiology of perioperative hypertension in patients sub jected to coronary artery surgery. Over the years, numer ous types of antihypertensives have been used for intravenous administration with the aim of preventing or treating perioperative hypertension. Nitrovasodilator compounds such as sodium nitroprusside and nitroglyc erin (NTG), a few calcium antagonists (nifedipine, nicar dipine and isradipine), the short-acting β-blocker esmo lol, clonidine, and the multifactorial compounds labetalol and ketanserin are discussed in detail. Perioperatively, there is an increasing level of plasma catecholamines, causing α-adrenoceptor stimulation. This indicates that α-adrenoceptor blockade with appropriate antagonists is a logical approach for the treatment of perioperative hypertension. For this reason, the multifactorial agent urapidil, which is an α-adrenoceptor blocker and a 5-HT_1A agonist, is discussed extensively.