Abstract
The Expert Panel for Cosmetic Ingredient Safety reviewed newly available studies since their original assessment in 1988, along with updated information regarding product types and concentrations of use, and confirmed that Amyl Acetate and Isoamyl Acetate are safe as cosmetic ingredients in the practices of use and concentration as described in this report.
The Expert Panel for Cosmetic Ingredient Safety first published a Final Report on the Safety Assessment of Amyl Acetate and Isoamyl Acetate in 1988. The Expert Panel concluded that these ingredients are safe as used as described in that safety assessment. 1
Current and Historical Frequency and Concentration of Use According to Duration and Exposure.
*Because each ingredient may be used in cosmetics with multiple exposure types, the sum of all exposure types may not equal the sum of total uses.
aIt is possible these products are sprays, but it is not specified whether the reported uses are sprays.
bIt is possible these products are powders, but it is not specified whether the reported uses are powders.
NR, no reported use.
An extensive search of the world’s literature was performed for studies dated 1982 forward, and new data were found.4-9 These data include subchronic inhalation toxicity data, developmental inhalation toxicity data, in vitro and in vivo genotoxicity data, and Research Institute for Fragrance Materials, Inc. safety assessments. The Expert Panel agreed, however, that the published literature did not reveal toxicity or other data that warrant re-evaluation of the safety of these ingredients in cosmetic products.
After reviewing updated frequency and concentration of use data and toxicity and safety data, the Expert Panel determined to not reopen this safety assessment on Amyl Acetate and Isoamyl Acetate and reaffirmed the original conclusion.
Footnotes
Author Notes
Unpublished sources cited in this report are available from the Director, Cosmetic Ingredient Review, 1620 L Street, NW, Suite 1200, Washington, DC 20036, USA.
Author Contributions
The articles in this supplement were sponsored by the Cosmetic Ingredient Review.
Declaration of Conflicting Interest
The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review.
Funding
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.