Chronic Stress in Children and Adolescents: A Review of Biomarkers for Use in Pediatric Research

Aardal E. Holm A. (1995). Cortisol in saliva-reference ranges and relation to cortisol in serum. Clinical Chemistry and Laboratory Medicine, 33, 927–932.

Adam E. K. Kumari M. (2009). Assessing salivary cortisol in large-scale, epidemiological research. Psychoneuroendocrinology, 34, 1423–1436.

Addison S. Stas S. Hayden M. R. Sowers J. R. (2008). Insulin resistance and blood pressure. Current Hypertension Reports, 10, 319–325.

Alkon A. Boyce W. T. Tran L. Harley K. G. Neuhaus J. Eskenazi B. (2014). Prenatal adversities and Latino children’s autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLoS One, 9, e86283. doi:10.1371/journal.pone.0086283

Andersen S. L. (2003). Trajectories of brain development: Point of vulnerability or window of opportunity? Neuroscience & Biobehavioral Reviews, 27, 3–18.

Apter-Levi Y. Pratt M. Vakart A. Feldman M. Zagoory-Sharon O. Feldman R. (2016). Maternal depression across the first years of life compromises child psychosocial adjustment; relations to child HPA-axis functioning. Psychoneuroendocrinology, 64, 47–56. doi:10.1016/j.psyneuen.2015.11.006

Barra C. B. Silva I. N. Rodrigues T. M. B. Santos J. L. S. Colosimo E. A. (2015). Morning serum basal cortisol levels are affected by age and pubertal maturation in school-aged children and adolescents. Hormone Research in Paediatrics, 83, 55–61. doi:10.1159/000369801

Belujon P. Grace A. A. (2015). Regulation of dopamine system responsivity and its adaptive and pathological response to stress. Proceedings of the Royal Society B: Biological Sciences, 282. doi:10.1098/rspb.2014.2516

Blakemore S. Choudhury S. (2006). Development of the adolescent brain: Implications for executive function and social cognition. Journal of Child Psychology and Psychiatry, 47, 296–312.

Blumenthal H. Leen-Feldner E. W. Badour C. L. Trainor C. D. Babson K. A. (2014). Pubertal maturation and cortisol level in response to a novel social environment among female adolescents. Journal of Adolescence, 37, 893–900. doi:10.1016/j.adolescence.2014.06.005

Bothe D. A. Grignon J. B. Olness K. N. (2014). The effects of a stress management intervention in elementary school children. Journal of Developmental and Behavioral Pediatrics, 35, 62–67. doi:10.1097/DBP.0000000000000016

Brady S. S. Matthews K. A. (2006). Chronic stress influences ambulatory blood pressure in adolescents. Annals of Behavioral Medicine, 31, 80–88.

Brandtzaeg P. (2009). Mucosal immunity: Induction, dissemination, and effector functions. Scandinavian Journal of Immunology, 70, 505–515.

Brody G. H. Yu T. Chen E. Miller G. E. (2014). Prevention moderates associations between family risks and youth catecholamine levels. Health Psychology, 33, 1435–1439. doi:10.1037/hea0000072

Broyles S. T. Staiano A. E. Drazba K. T. Gupta A. K. Sothern M. Katzmarzyk P. T. (2012). Elevated C-reactive protein in children from risky neighborhoods: Evidence for a stress pathway linking neighborhoods and inflammation in children. PLoS One, 7, e45419.

Bücker J. Fries G. R. Kapczinski F. Post R. M. Yatham L. N. Vianna P. … Kauer-Sant’Anna M. (2015). Brain-derived neurotrophic factor and inflammatory markers in school-aged children with early trauma. Acta Psychiatrica Scandinavica, 131, 360–368. doi:10.1111/acps.12358

Buss C. Davis E. P. Shahbaba B. Pruessner J. C. Head K. Sandman C. A. (2012). Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proceedings of the National Academy of Sciences of the United States of America, 109, E1312–E1319. doi:10.1073/pnas.1201295109

Calcagni E. Elenkov I. (2006). Stress system activity, innate and T helper cytokines, and susceptibility to immune-related diseases. Annals of the New York Academy of Sciences, 1069, 62–76.

Calkins S. D. Graziano P. A. Berdan L. E. Keane S. P. Degnan K. A. (2008). Predicting cardiac vagal regulation in early childhood from maternal–child relationship quality during toddlerhood. Developmental Psychobiology, 50, 751–766. doi:10.1002/dev.20344

Carlsson E. Frostell A. Ludvigsson J. Faresjo M. (2014). Psychological stress in children may alter the immune response. Journal of Immunology, 192, 2071–2081. doi:10.4049/jimmunol.1301713

Carrión V. G. Haas B. W. Garrett A. Song S. Reiss A. L. (2010). Reduced hippocampal activity in youth with posttraumatic stress symptoms: An fMRI study. Journal of Pediatric Psychology, 35, 559–569. doi:10.1093/jpepsy/jsp112

Carroll-Scott A. Gilstad-Hayden K. Rosenthal L. Peters S. M. McCaslin C. Joyce R. Ickovics J. R. (2013). Disentangling neighborhood contextual associations with child body mass index, diet, and physical activity: The role of built, socioeconomic, and social environments. Social Science and Medicine, 95, 106–114. doi:10.1016/j.socscimed.2013.04.003

Carter J. S. Dellucci T. Turek C. Mir S. (2015). Predicting depressive symptoms and weight from adolescence to adulthood: Stressors and the role of protective factors. Journal of Youth and Adolescence, 44, 2122–2140. doi:10.1007/s10964-015-0301-5

Caserta M. T. Wyman P. A. Wang H. Moynihan J. O’Connor T. G. (2011). Associations among depression, perceived self-efficacy, and immune function and health in preadolescent children. Development and Psychopathology, 23, 1139–1147. doi:10.1017/S0954579411000526

Chandola T. Brunner E. Marmot M. (2006). Chronic stress at work and the metabolic syndrome: Prospective study. BMJ (Clinical Research Ed.), 332, 521–525.

Charmandari E. Tsigos C. Chrousos G. (2005). Endocrinology of the stress response. Annual Review of Physiology, 67, 259–284. doi:10.1146/annurev.physiol.67.040403.120816

Chen E. Fisher E. B. Bacharier L. B. Strunk R. C. (2003). Socioeconomic status, stress, and immune markers in adolescents with asthma. Psychosomatic Medicine, 65, 984–992. doi:10.1097/01.PSY.0000097340.54195.3C

Chen E. Lee W. K. Cavey L. Ho A. (2013). Role models and the psychological characteristics that buffer low-socioeconomic-status youth from cardiovascular risk. Child Development, 84, 1241–1252. doi:10.1111/cdev.12037

Chen E. Strunk R. C. Trethewey A. Schreier H. M. C. Maharaj N. Miller G. E. (2011). Resilience in low-socioeconomic-status children with asthma: Adaptations to stress. Journal of Allergy and Clinical Immunology, 128, 970–976. doi:10.1016/j.jaci.2011.06.040

Chen F. R. Raine A. Soyfer L. Granger D. A. (2015). Interaction of adrenocortical activity and autonomic arousal on children’s externalizing and internalizing behavior problems. Journal of Abnormal Child Psychology, 43, 189–202. doi:10.1007/s10802-014-9900-y

Chen X. Gelaye B. Velez J. C. Barbosa C. Pepper M. Andrade A. … Williams M. A. (2015). Caregivers’ hair cortisol: A possible biomarker of chronic stress is associated with obesity measures among children with disabilities. BMC Pediatrics, 15, 9. doi:10.1186/s12887-015-0322-y

Clark R. Armstead C. (2000). Family conflict predicts blood pressure changes in African-American adolescents: A preliminary examination. Journal of Adolescence, 23, 355–358. doi:10.1006/jado.2000.0320

Coelho R. Viola T. W. Walss-Bass C. Brietzke E. Grassi-Oliveira R. (2014). Childhood maltreatment and inflammatory markers: A systematic review. Acta Psychiatrica Scandinavica, 129, 180–192. doi:10.1111/acps.12217

Colburn W. DeGruttola V. DeMets D. Downing G. Hoth D. Oates J. … Woodcock J. (2001). Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clinical Pharmacology & Therapeutics, 69, 89–95.

Condon E. M . (2016). Psychosocial influences on acceptability and feasibility of salivary cortisol collection from community samples of children. Research in Nursing & Health, 39, 449–462.

Corbie-Smith G. Thomas S. B. George D. M. M. S. (2002). Distrust, race, and research. Archives of Internal Medicine, 162, 2458–2463.

Costa de Oliveira Forkert E. de Moraes A. C. F. Carvalho H. B. Kafatos A. Manios Y. Sjöström M. … Moreno L. A. (2016). Abdominal obesity and its association with socioeconomic factors among adolescents from different living environments. Pediatric Obesity, 12, 110–119. doi:10.1111/ijpo.12116

Cunha G. R. Asevedo E. Mansur R. B. Zugman A. Pan P. M. Gadelha A. … Brietzke E. (2016). Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample. Acta Psychiatrica Scandinavica, 133, 122–132. doi:10.1111/acps.12453

Curcio R. Stettler H. Suter P. M. Aksözen J. B. Saleh L. Spanaus K. … von Eckardstein A. (2016). Reference intervals for 24 laboratory parameters determined in 24-hour urine collections. Clinical Chemistry and Laboratory Medicine (CCLM), 54, 105–116.

Danese A. Dove R. Belsky D. W. Henchy J. Williams B. Ambler A. Arseneault L. (2014). Leptin deficiency in maltreated children. Translational Psychiatry, 4, e446. doi:10.1038/tp.2014.79

Danesh J. Wheeler J. G. Hirschfield G. M. Eda S. Eiriksdottir G. Rumley A. … Gudnason V. (2004). C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. New England Journal of Medicine, 350, 1387–1397.

Davis H. Treiber F. A. (2007). Perceived stress, heart rate, and blood pressure among adolescents with family members deployed in operation Iraqi freedom. Military Medicine, 172, 40–43.

De Bellis M. D. Baum A. S. Birmaher B. Ryan N. D. (1997). Urinary catecholamine excretion in childhood overanxious and posttraumatic stress disorders. Annals of the New York Academy of Sciences, 821, 451–455. doi:10.1111/j.1749-6632.1997.tb48303.x

De Bellis M. D. Lefter L. Trickett P. K. Putnam F. W. (1994). Urinary catecholamine excretion in sexually abused girls. Journal of the American Academy of Child & Adolescent Psychiatry, 33, 320–327.

Dixon D. Meng H. Goldberg R. Schneiderman N. Delamater A. (2009). Stress and body mass index each contributes independently to tumor necrosis factor-α production in prepubescent Latino children. Journal of Pediatric Nursing, 24, 378–388. doi:10.1016/j.pedn.2008.02.034

Doan S. N. Dich N. Evans G. W. (2014). Childhood cumulative risk and later allostatic load: Mediating role of substance use. Health Psychology, 33, 1402–1409.

Doan S. N. Evans G. W. (2011). Maternal responsiveness moderates the relationship between allostatic load and working memory. Development and Psychopathology, 23, 873–880.

Dobrova-Krol N. A. van IJzendoorn M. H. Bakermans-Kranenburg M. J. Cyr C. Juffer F. (2008). Physical growth delays and stress dysregulation in stunted and non-stunted Ukrainian institution-reared children. Infant Behavior and Development, 31, 539–553. doi:10.1016/j.infbeh.2008.04.001

Doom J. R. Cicchetti D. Rogosch F. A. Dackis M. N. (2013). Child maltreatment and gender interactions as predictors of differential neuroendocrine profiles. Psychoneuroendocrinology, 38, 1442–1454. doi:10.1016/j.psyneuen.2012.12.019

Dossus L. Becker S. Achaintre D. Kaaks R. Rinaldi S. (2009). Validity of multiplex-based assays for cytokine measurements in serum and plasma from “non-diseased” subjects: Comparison with ELISA. Journal of Immunological Methods, 350, 125–132.

Drummond P. D. Hewson-Bower B. (1997). Increased psychosocial stress and decreased mucosal immunity in children with recurrent upper respiratory tract infections. Journal of Psychosomatic Research, 43, 271–278. doi:10.1016/S0022-3999(97)00002-0

Du Clos T. W. Mold C. (2004). C-reactive protein. Immunologic Research, 30, 261–277.

El-Sheikh M. Buckhalt J. A. Granger D. A. Erath S. A. Acebo C. (2007). The association between children’s sleep disruption and salivary interleukin-6. Journal of Sleep Research, 16, 188–197. doi:10.1111/j.1365-2869.2007.00593.x

El-Sheikh M. Hinnant J. B. (2011). Marital conflict, respiratory sinus arrhythmia, and allostatic load: Interrelations and associations with the development of children’s externalizing behavior. Development and Psychopathology, 23, 815–829. doi:10.1017/S0954579411000320

Engeland C. G. Hugo F. N. Hilgert J. B. Nascimento G. G. Junges R. Lim H.-J. … Bosch J. A. (2016). Psychological distress and salivary secretory immunity. Brain, Behavior, and Immunity, 52, 11–17. doi:10.1016/j.bbi.2015.08.017

Essex M. J. Klein M. H. Cho E. Kalin N. H. (2002). Maternal stress beginning in infancy may sensitize children to later stress exposure: Effects on cortisol and behavior. Biological Psychiatry, 52, 776–784. doi:10.1016/S0006-3223(02)01553-6

Evans B. E. Greaves-Lord K. Euser A. S. Tulen J. H. M. Franken I. H. A. Huizink A. C. (2013). Determinants of physiological and perceived physiological stress reactivity in children and adolescents. PLoS One, 8. doi:10.1371/journal.pone.0061724

Evans G. W. (2003). A multimethodological analysis of cumulative risk and allostatic load among rural children. Developmental Psychology, 39, 924–933.

Evans G. W. (2013, 11). Residential noise exposure and chronic stress in children. Paper presented at the annual conference of the Australian acoustical society 2013: Science, Technology and Amenity, Victor Harbor, Australia. Retrieved from https://www.acoustics.asn.au/conference_proceedings/AAS2013/papers/p85.pdf

Evans G. W. Exner-Cortens D. Kim P. Bartholomew D. (2013). Childhood poverty and blood pressure reactivity to and recovery from an acute stressor in late adolescence: The mediating role of family conflict. Psychosomatic Medicine, 75, 691–700. doi:10.1097/PSY.0b013e31829f9823

Evans G. W. Fuller-Rowell T. E. (2013). Childhood poverty, chronic stress, and young adult working memory: The protective role of self-regulatory capacity. Developmental Science, 16, 688–696.

Evans G. W. Fuller-Rowell T. E. Doan S. N. (2012). Childhood cumulative risk and obesity: The mediating role of self-regulatory ability. Pediatrics, 129, e68–e73. doi:10.1542/peds.2010-3647

Evans G. W. Kim P. (2012). Childhood poverty and young adults’ allostatic load: The mediating role of childhood cumulative risk exposure. Psychological Science, 23, 979–983. doi:10.1177/0956797612441218

Evans G. W. Kim P. Ting A. H. Tesher H. B. Shannis D. (2007). Cumulative risk, maternal responsiveness, and allostatic load among young adolescents. Developmental Psychology, 43, 341–351. doi:10.1037/0012-1649.43.2.341

Farr O. M. Ko B.-J. Joung K. E. Zaichenko L. Usher N. Tsoukas M. … Mantzoros C. S. (2015). Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk. Nutrition, Metabolism and Cardiovascular Diseases, 25, 479–488. doi:10.1016/j.numecd.2015.01.007

Fierman A. H. Dreyer B. P. Quinn L. Shulman S. Courtlandt C. D. Guzzo R. (1991). Growth delay in homeless children. Pediatrics, 88, 918–925.

Fisher P. A. Beauchamp K. G. Roos L. E. Noll L. K. Flannery J. Delker B. C. (2016). The neurobiology of intervention and prevention in early adversity. Annual Review of Clinical Psychology, 12, 331–357. doi:10.1146/annurev-clinpsy-032814-112855

Ford J. L. Boch S. J. McCarthy D. O. (2016). Feasibility of hair collection for cortisol measurement in population research on adolescent health. Nursing Research, 65, 249–255.

Fox S. E. Levitt P. Nelson C. A. III (2010). How the timing and quality of early experiences influence the development of brain architecture. Child Development, 81, 28–40.

Francis L. A. Granger D. A. Susman E. J. (2013). Adrenocortical regulation, eating in the absence of hunger and BMI in young children. Appetite, 64, 32–38. doi:10.1016/j.appet.2012.11.008

Freedman D. S. Sherry B. (2009). The validity of BMI as an indicator of body fatness and risk among children. Pediatrics, 124, S23–S34. doi:10.1542/peds.2008-3586E

Friedman E. M. Karlamangla A. S. Gruenewald T. L. Koretz B. Seeman T. E. (2015). Early life adversity and adult biological risk profiles. Psychosomatic Medicine, 77(2), 176–185. doi:10.1097/PSY.0000000000000147

Fries A. B. W. Shirtcliff E. A. Pollak S. D. (2008). Neuroendocrine dysregulation following early social deprivation in children. Developmental Psychobiology, 50, 588–599. doi:10.1002/dev.20319

Fuligni A. J. Telzer E. H. Bower J. Cole S. W. Kiang L. Irwin M. R. (2009). A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds. Psychosomatic Medicine, 71, 329–333. doi:10.1097/PSY.0b013e3181921b1f

Gariup M. Gonzalez A. Lázaro L. Torres F. Serra-Pagès C. Morer A. (2015). IL-8 and the innate immunity as biomarkers in acute child and adolescent psychopathology. Psychoneuroendocrinology, 62, 233–242. doi:10.1016/j.psyneuen.2015.08.017

Garner A. S. Shonkoff J. P. , Committee on Psychosocial Aspects of Child and Family Health, Committee on Early Childhood, Adoption, and Dependent Care, & Section on Developmental and Behavioral Pediatrics. (2012). Early childhood adversity, toxic stress, and the role of the pediatrician: Translating developmental science into lifelong health. Pediatrics, 129, e224–e2231. doi:10.1542/peds.2011-2662

Giustina A. Wehrenberg W. B. (1992). The role of glucocorticoids in the regulation of growth hormone secretion mechanisms and clinical significance. Trends in Endocrinology & Metabolism, 3, 306–311.

Goldbacher E. M. Matthews K. A. Salomon K. (2005). Central adiposity is associated with cardiovascular reactivity to stress in adolescents. Health Psychology, 24, 375–384. doi:10.1037/0278-6133.24.4.375

Goldman-Mellor S. Brydon L. Steptoe A. (2010). Psychological distress and circulating inflammatory markers in healthy young adults. Psychological Medicine, 40, 2079–2087. doi:10.1017/S0033291710000267

Gomez M. T. Malozowski S. Winterer J. Vamvakopoulos N. C. Chrousos G. P. (1991). Urinary free cortisol values in normal children and adolescents. Journal of Pediatrics, 118, 256–258.

Goodman E. Daniels S. R. Dolan L. M. (2007). Socioeconomic disparities in insulin resistance: Results from the Princeton school district study. Psychosomatic Medicine, 69, 61–67. doi:10.1097/01.psy.0000249732.96753.8f

Goodman E. Must A. Daniels S. R. Dolan L. M. (2010). Hostility and adiposity mediate disparities in insulin resistance among adolescents and young adults. Journal of Pediatrics, 157, 572–577.e1. doi:10.1016/j.jpeds.2010.04.048

Gordis E. B. Granger D. A. Susman E. J. Trickett P. K. (2006). Asymmetry between salivary cortisol and α-amylase reactivity to stress: Relation to aggressive behavior in adolescents. Psychoneuroendocrinology, 31, 976–987.

Gow R. Thomson S. Rieder M. Van Uum S. Koren G. (2010). An assessment of cortisol analysis in hair and its clinical applications. Forensic Science International, 196, 32–37. doi:10.1016/j.forsciint.2009.12.040

Granger D. A. Johnson S. B. Szanton S. L. Out D. Schumann L. L. (2012). Incorporating salivary biomarkers into nursing research: An overview and review of best practices. Biological Research for Nursing, 14, 347–356.

Granger D. A. Kivlighan K. T. El-Sheikh M. Gordis E. B. Stroud L. R. (2007). Salivary a-amylase in biobehavioral research: Recent developments and applications. Annals of the New York Academy of Sciences, 1098, 122–144. doi:10.1196/annals.1384.008

Granger D. A. Kivlighan K. T. Fortunato C. Harmon A. G. Hibel L. C. Schwartz E. B. Whembolua G. (2007). Integration of salivary biomarkers into developmental and behaviorally-oriented research: Problems and solutions for collecting specimens. Physiology & Behavior, 92, 583–590.

Grassi G. Ram V. S. (2016). Evidence for a critical role of the sympathetic nervous system in hypertension. Journal of the American Society of Hypertension, 10, 457–466. doi:10.1016/j.jash.2016.02.015

Groeneveld M. G. Vermeer H. J. Linting M. Noppe G. van Rossum E. F. van IJzendoorn M. H. (2013). Children’s hair cortisol as a biomarker of stress at school entry. Stress, 16, 711–715.

Grossman P. Taylor E. W. (2007). Toward understanding respiratory sinus arrhythmia: Relations to cardiac vagal tone, evolution and biobehavioral functions. Biological Psychology, 74, 263–285.

Gunnar M. R. Fisher P. A. Dozier M. Fox N. Levine S. Neal C. … Vazquez D. (2006). Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Development and Psychopathology, 18, 651–677. doi:10.1017/S0954579406060330

Gunnar M. R. Frenn K. Wewerka S. S. Van Ryzin M. J. (2009). Moderate versus severe early life stress: Associations with stress reactivity and regulation in 10–12-year-old children. Psychoneuroendocrinology, 34, 62–75.

Gunnar M. R. Morison S. J. Chisholm K. Schuder M. (2001). Salivary cortisol levels in children adopted from Romanian orphanages. Development and Psychopathology, 13, 611–628. doi:10.1017/S095457940100311X

Hair N. L. Hanson J. L. Wolfe B. L. Pollak S. D. (2015). Association of child poverty, brain development, and academic achievement. JAMA Pediatrics, 169, 822–829.

Hanrahan K. McCarthy A. M. Kleiber C. Lutgendorf S. Tsalikian E. (2006). Strategies for salivary cortisol collection and analysis in research with children. Applied Nursing Research, 19, 95–101.

Hanson J. L. Chandra A. Wolfe B. L. Pollak S. D. (2011). Association between income and the hippocampus. PLoS One, 6, e18712.

Hanson J. L. Nacewicz B. M. Sutterer M. J. Cayo A. A. Schaefer S. M. Rudolph K. D. … Davidson R. J. (2015). Behavioral problems after early life stress: Contributions of the hippocampus and amygdala. Biological Psychiatry, 77, 314–323.

Hatzinger M. Brand S. Perren S. Von Wyl A. Stadelmann S. von Klitzing K. Holsboer-Trachsler E. (2013). In pre-school children, cortisol secretion remains stable over 12 months and is related to psychological functioning and gender. Journal of Psychiatric Research, 47, 1409–1416. doi:10.1016/j.jpsychires.2013.05.030

Hertzman C. Boyce T. (2010). How experience gets under the skin to create gradients in developmental health. Annual Review of Public Health, 31, 329–347.

Hill E. E. Eisenmann J. C. Gentile D. Holmes M. E. Walsh D. (2011). The association between morning cortisol and adiposity in children varies by weight status. Journal of Pediatric Endocrinology and Metabolism, 24, 709–713. doi:10.1515/JPEM.2011.267

Hillis S. D. Mercy J. A. Saul J. R. (2017). The enduring impact of violence against children. Psychology, Health & Medicine, 22, 393–405.

Hinnant J. B. El-Sheikh M. Keiley M. Buckhalt J. A. (2013). Marital conflict, allostatic load, and the development of children’s fluid cognitive performance. Child Development, 84, 2003–2014. doi:10.1111/cdev.12103

Hinnant J. B. Erath S. A. El-Sheikh M. (2015). Harsh parenting, parasympathetic activity, and development of delinquency and substance use. Journal of Abnormal Psychology, 124, 137–151. doi:10.1037/abn0000026

Hodel A. S. Hunt R. H. Cowell R. A. Van Den Heuvel S. E. Gunnar M. R. Thomas K. M. (2015). Duration of early adversity and structural brain development in post-institutionalized adolescents. NeuroImage, 105, 112–119. doi:10.1016/j.neuroimage.2014.10.020

Hollar D. Lombardo M. Lopez-Mitnik G. Hollar T. L. Almon M. Agatston A. S. Messiah S. E. (2010). Effective multi-level, multi-sector, school-based obesity prevention programming improves weight, blood pressure, and academic performance, especially among low-income, minority children. Journal of Health Care for the Poor and Underserved, 21, 93–108.

Holman E. A. (2015). Psychological distress and susceptibility to cardiovascular disease across the lifespan: Implications for future research and clinical practice. Journal of the American College of Cardiology, 66, 1587–1589. doi:10.1016/j.jacc.2015.08.026

Hostinar C. E. Johnson A. E. Gunnar M. R. (2015). Early social deprivation and the social buffering of cortisol stress responses in late childhood: An experimental study. Developmental Psychology, 51, 1597–1608. doi:10.1037/dev0000029

Hotamisligil G. S. Shargill N. S. Spiegelman B. M. (1993). Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science, 259, 87–91.

Houseknecht K. L. Baile C. A. Matteri R. L. Spurlock M. E. (1998). The biology of leptin: A review. Journal of Animal Science, 76, 1405–1420.

Institute of Medicine. (2010). Evaluation of biomarkers and surrogate endpoints in chronic disease. Washington, DC: National Academies Press. doi:10.17226/12869

Jednoróg K. Altarelli I. Monzalvo K. Fluss J. Dubois J. Billard C. … Ramus F. (2012). The influence of socioeconomic status on children’s brain structure. PLoS One, 7, e42486.

Jessop D. S. Turner-Cobb J. M. (2008). Measurement and meaning of salivary cortisol: A focus on health and disease in children: Review. Stress, 11, 1–14.

Johansson S. Norman M. Legnevall L. Dalmaz Y. Lagercrantz H. Vanpée M. (2007). Increased catecholamines and heart rate in children with low birth weight: Perinatal contributions to sympathoadrenal overactivity. Journal of Internal Medicine, 261, 480–487. doi:10.1111/j.1365-2796.2007.01776.x

Johnson A. E. Bruce J. Tarullo A. R. Gunnar M. R. (2011). Growth delay as an index of allostatic load in young children: Predictions to disinhibited social approach and diurnal cortisol activity. Development and Psychopathology, 23, 859–871. doi:10.1017/S0954579411000356

Johnson S. B. Riis J. L. Noble K. G . (2016). State of the art review: Poverty and the developing brain. Pediatrics, 137, e20153075–e20153075. doi:10.1542/peds.2015-3075

Johnson S. B. Riley A. W. Granger D. A. Riis J. (2013). The science of early life toxic stress for pediatric practice and advocacy. Pediatrics, 131, 319–327. doi:10.1542/peds.2012-0469

Joung K. E. Park K.-H. Zaichenko L. Sahin-Efe A. Thakkar B. Brinkoetter M. … Mantzoros C. S. (2014). Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults. Journal of Clinical Endocrinology and Metabolism, 99, E1055–E1060. doi:10.1210/jc.2013-3669

Juster R. McEwen B. S. Lupien S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience & Biobehavioral Reviews, 35, 2–16.

Karlen J. Frostell A. Theodorsson E. Faresjo T. Ludvigsson J. (2013). Maternal influence on child HPA axis: A prospective study of cortisol levels in hair. Pediatrics, 132, e1333–e1340. doi:10.1542/peds.2013-1178

Karlen J. Ludvigsson J. Hedmark M. Faresjo A. Theodorsson E. Faresjo T. (2015). Early psychosocial exposures, hair cortisol levels, and disease risk. Pediatrics, 135, e1450–e1457. doi:10.1542/peds.2014-2561

Keeshin B. R. Strawn J. R. Out D. Granger D. A. Putnam F. W. (2015). Elevated salivary alpha amylase in adolescent sexual abuse survivors with posttraumatic stress disorder symptoms. Journal of Child and Adolescent Psychopharmacology, 25, 344–350. doi:10.1089/cap.2014.0034

Keil M. F. (2012). Salivary cortisol: A tool for biobehavioral research in children. Journal of Pediatric Nursing, 27, 287–289. doi:10.1016/j.pedn.2012.02.003

Keller P. S. El-Sheikh M. Vaughn B. Granger D. A. (2010). Relations between mucosal immunity and children’s mental health: The role of child sex. Physiology and Behavior, 101, 705–712. doi:10.1016/j.physbeh.2010.08.012

Kemeny M. E. Schedlowski M. (2007). Understanding the interaction between psychosocial stress and immune-related diseases: A stepwise progression. Brain, Behavior, and Immunity, 21, 1009–1018.

Kepper M. Sothern M. Zabaleta J. Ravussin E. Velasco-Gonzalez C. Leonardi C. … Scribner R. (2016). Prepubertal children exposed to concentrated disadvantage: An exploratory analysis of inflammation and metabolic dysfunction. Obesity, 24, 1148–1153. doi:10.1002/oby.21462

Kim J. J. Yoon K. S. (1998). Stress: Metaplastic effects in the hippocampus. Trends in Neurosciences, 21, 505–509.

Klein Z. A. Romeo R. D. (2013). Changes in hypothalamic-pituitary-adrenal stress responsiveness before and after puberty in rats. Hormones and Behavior, 64, 357–363. doi:10.1016/j.yhbeh.2013.01.012

Kohlboeck G. Romanos M. Tiesler C. Koletzko S. Kratzsch J. Thiery J. … Heinrich J. (2014). Peer problems are associated with elevated serum leptin levels in children. Psychological Medicine, 44, 255–265. doi:10.1017/S003329171300069X

Koss K. J. George M. R. Cummings E. M. Davies P. T. El-Sheikh M. Cicchetti D. (2014). Asymmetry in children’s salivary cortisol and alpha-amylase in the context of marital conflict: Links to children’s emotional security and adjustment. Developmental Psychobiology, 56, 836–849. doi:10.1002/dev.21156

Kozyrskyj A. L. Zeng Y. Colman I. Hayglass K. T. Sellers E. A. C. Becker A. B. MacNeil B. J. (2011). Maternal distress in early life predicts the waist-to-hip ratio in schoolchildren. Journal of Developmental Origins of Health and Disease, 2, 72–80. doi:10.1017/S2040174410000723

Krause-Parello C. A. Friedmann E. (2014). The effects of an animal-assisted intervention on salivary alpha-amylase, salivary immunoglobulin a, and heart rate during forensic interviews in child sexual abuse cases. Anthrozoos, 27, 581–590. doi:10.2752/089279314X14072268688005

Krenichyn K. Saegert S. Evans G. W. (2001). Parents as moderators of psychological and physiological correlates of inner-city children’s exposure to violence. Journal of Applied Developmental Psychology, 22, 581–602. doi:10.1016/S0193-3973(01)00095-8

Kushner M. R. Barrios C. Smith V. C. Dougherty L. R. (2015). Physiological and behavioral vulnerability markers increase risk to early life stress in preschool-aged children. Journal of Abnormal Child Psychology, 44, 859–870. doi:10.1007/s10802-015-0087-7

Kwok M. K. Subramanian S. V. Leung G. M. Schooling C. M. (2015). Household income and adolescent blood pressure in a Chinese birth cohort: “Children of 1997.” Social Science and Medicine, 144, 88–95. doi:10.1016/j.socscimed.2015.09.012

Landstra A. M. Postma D. S. Boezen H. M. Van Aalderen W. M. (2012). Role of serum cortisol levels in children with asthma. American Journal of Respiratory and Critical Care Medicine, 165, 708–712. doi:10.1164/ajrccm.165.5.2102115

Laudat M. Cerdas S. Fournier C. Guiban D. Guilhaume B. Luton J. (1988). Salivary cortisol measurement: A practical approach to assess pituitary-adrenal function. Journal of Clinical Endocrinology & Metabolism, 66, 343–348.

Leng S. X. McElhaney J. E. Walston J. D. Xie D. Fedarko N. S. Kuchel G. A. (2008). ELISA and multiplex technologies for cytokine measurement in inflammation and aging research. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63, 879–884.

Liu C. H. Snidman N. Leonard A. Meyer J. Tronick E. (2016). Intra-individual stability and developmental change in hair cortisol among postpartum mothers and infants: Implications for understanding chronic stress. Developmental Psychobiology, 58, 509–518. doi:10.1002/dev.21394

Liu G. T. Dancause K. N. Elgbeili G. Laplante D. P. King S. (2016). Disaster-related prenatal maternal stress explains increasing amounts of variance in body composition through childhood and adolescence: Project Ice Storm. Environmental Research, 150, 1–7. doi:10.1016/j.envres.2016.04.039

Lopez-Castejon G. Brough D. (2011). Understanding the mechanism of IL-1ß secretion. Cytokine and Growth Factor Reviews, 22, 189–195. doi:10.1016/j.cytogfr.2011.10.001

Low C. A. Matthews K. A. Hall M. (2013). Elevated C-reactive protein in adolescents: Roles of stress and coping. Psychosomatic Medicine, 75, 449–452. doi:10.1097/PSY.0b013e31828d3f1d

Luby J. Belden A. Botteron K. Marrus N. Harms M. P. Babb C. … Barch D. (2013). The effects of poverty on childhood brain development: The mediating effect of caregiving and stressful life events. JAMA Pediatrics, 167, 1135–1142.

Luby J. L. Barch D. M. Belden A. Gaffrey M. S. Tillman R. Babb C. … Botteron K. N. (2012). Maternal support in early childhood predicts larger hippocampal volumes at school age. Proceedings of the National Academy of Sciences of the United States of America, 109, 2854–2859. doi:10.1073/pnas.1118003109

Lupien S. J. King S. Meaney M. J. McEwen B. S. (2000). Child’s stress hormone levels correlate with mother’s socioeconomic status and depressive state. Biological Psychiatry, 48, 976–980. doi:10.1016/S0006-3223(00)00965-3

Lupien S. J. Parent S. Evans A. C. Tremblay R. E. Zelazo P. D. Corbo V. … Seguin J. R . (2011). Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth. Proceedings of the National Academy of Sciences of the United States of America, 108, 14324–1432. doi:10.1073/pnas.1105371108

Malakasioti G. Alexopoulos E. I. Varlami V. Chaidas K. Liakos N. Gourgoulianis K. Kaditis A. G. (2013). Low morning serum cortisol levels in children with tonsillar hypertrophy and moderate-to-severe OSA. Sleep, 36, 1349–1354. doi:10.5665/sleep.2962

Mantis N. J. Rol N. Corthésy B. (2011). Secretory IgA’s complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunology, 4, 603–611.

Mantzoros C. S. Magkos F. Brinkoetter M. Sienkiewicz E. Dardeno T. A. Kim S. Y. … Koniaris A. (2011). Leptin in human physiology and pathophysiology. American Journal of Physiology, Endocrinology and Metabolism, 301, E567–E584. doi:10.1152/ajpendo.00315.2011

Martinovic M. Belojevic G. Evans G. W. Asanin B. Lausevic D. Kovacevic N. D. … Pantovic S . (2014). Blood pressure among rural Montenegrin children in relation to poverty and gender. European Journal of Public Health, 24, 385–389. doi:10.1093/eurpub/ckt181

Marton M. J. Weiner R. (2013). Practical guidance for implementing predictive biomarkers into early phase clinical studies. BioMed Research International, 2013, 9. doi:10.1155/2013/891391

McCrory E. De Brito S. A. Viding E. (2011). The impact of childhood maltreatment: A review of neurobiological and genetic factors. Frontiers in Psychiatry, 2, 48.

McEwen B. S. (2003). Interacting mediators of allostasis and allostatic load: Towards an understanding of resilience in aging. Metabolism, 52, 10–16.

McEwen B. S. (2008). Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. European Journal of Pharmacology, 583, 174–185.

McEwen B. S. (2012). Brain on stress: How the social environment gets under the skin. Proceedings of the National Academy of Sciences of the United States of America, 109, 17180–17185. doi:10.1073/pnas.1121254109

McEwen B. S. Wingfield J. C. (2003). The concept of allostasis in biology and biomedicine. Hormones and Behavior, 43, 2–15.

McGrath J. J. Matthews K. A. Brady S. S. (2006). Individual versus neighborhood socioeconomic status and race as predictors of adolescent ambulatory blood pressure and heart rate. Social Science and Medicine, 63, 1442–1453. doi:10.1016/j.socscimed.2006.03.019

Meyer J. S. Novak M. A. (2012). Minireview: Hair cortisol: A novel biomarker of hypothalamic-pituitary-adrenocortical activity. Endocrinology, 153, 4120–4127.

Michels N. Sioen I. Clays E. De Buyzere M. Ahrens W. Huybrechts I. … De Henauw S. (2013). Children’s heart rate variability as stress indicator: Association with reported stress and cortisol. Biological Psychology, 94, 433–440. doi:10.1016/j.biopsycho.2013.08.005

Miller A. L. Clifford C. Sturza J. Rosenblum K. Vazquez D. M. Kaciroti N. Lumeng J. C. (2013). Blunted cortisol response to stress is associated with higher body mass index in low-income preschool-aged children. Psychoneuroendocrinology, 38, 2611–2617. doi:10.1016/j.psyneuen.2013.06.014

Miller A. L. Sturza J. Rosenblum K. Vazquez D. M. Kaciroti N. Lumeng J. C. (2015). Salivary alpha amylase diurnal pattern and stress response are associated with body mass index in low-income preschool-aged children. Psychoneuroendocrinology, 53, 40–48. doi:10.1016/j.psyneuen.2014.12.011

Miller G. E. Chen E. Zhou E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychological Bulletin, 133, 25–45. doi:10.1037/0033-2909.133.1.25

Mills N. T. Scott J. G. Wray N. R. Cohen-Woods S. Baune B. T. (2013). Research review: The role of cytokines in depression in adolescents: A systematic review. Journal of Child Psychology and Psychiatry and Allied Disciplines, 54, 816–835. doi:10.1111/jcpp.12080

Moore G. A. (2010). Parent conflict predicts infants’ vagal regulation in social interaction. Development and Psychopathology, 22, 23–33. doi:10.1017/S095457940999023X

Morey J. N. Boggero I. A. Scott A. B. Segerstrom S. C. (2015). Current directions in stress and human immune function. Current Opinion in Psychology, 5, 13–17.

Muller D. Errington S. Szabo C. P. Pitts N. Jacklin L. (2014). Cortisol and IL-6 responses to stress in female children presenting at a sexual abuse clinic. Journal of Child and Adolescent Trauma, 7, 185–191. doi:10.1007/s40653-014-0019-7

Murali R. Chen E. (2005). Exposure to violence and cardiovascular and neuroendocrine measures in adolescents. Annals of Behavioral Medicine, 30, 155–163. doi:10.1207/s15324796abm3002_8

Mushtaq M. U. Gull S. Abdullah H. M. Shahid U. Shad M. A. Akram J. (2011). Waist circumference, waist-hip ratio and waist-height ratio percentiles and central obesity among Pakistani children aged five to twelve years. BMC Pediatrics, 11, 105.

Nakavachara P. Viprakasit V. (2013). Adrenal insufficiency is prevalent in HbE/ß-thalassaemia paediatric patients irrespective of their clinical severity and transfusion requirement. Clinical Endocrinology, 79, 776–783. doi:10.1111/cen.12235

Nater U. M. Rohleder N. (2009). Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research. Psychoneuroendocrinology, 34, 486–496. doi:10.1016/j.psyneuen.2009.01.014

Negriff S. Saxbe D. E. Trickett P. K. (2015). Childhood maltreatment, pubertal development, HPA axis functioning, and psychosocial outcomes: An integrative biopsychosocial model. Developmental Psychobiology, 57, 984–993. doi:10.1002/dev.21340

Neovius M. Linne Y. Rossner S. (2005). BMI, waist-circumference and waist-hip-ratio as diagnostic tests for fatness in adolescents. International Journal of Obesity, 29, 163–169.

Noble K. G. Houston S. M. Brito N. H. Bartsch H. Kan E. Kuperman J. M. … Libiger O. (2015). Family income, parental education and brain structure in children and adolescents. Nature Neuroscience, 18, 773–778.

Noble K. G. Houston S. M. Kan E. Sowell E. R. (2012). Neural correlates of socioeconomic status in the developing human brain. Developmental Science, 15, 516–527.

Olney R. C. (2009). Mechanisms of impaired growth: Effect of steroids on bone and cartilage. Hormone Research, 72, 30–35. doi:10.1159/000229761

Olstad D. L. Ball K. Wright C. Abbott G. Brown E. Turner A. I. (2016). Hair cortisol levels, perceived stress and body mass index in women and children living in socioeconomically disadvantaged neighborhoods: The READI study. Stress, 19, 158–167. doi:10.3109/10253890.2016.1160282

Oosterman M. De Schipper J. C. Fisher P. Dozier M. Schuengel C. (2010). Autonomic reactivity in relation to attachment and early adversity among foster children. Development and Psychopathology, 22, 109–118. doi:10.1017/S0954579409990290

Östberg V. Almquist Y. B. Folkesson L. Låftman S. B. Modin B. Lindfors P. (2015). The complexity of stress in mid-adolescent girls and boys: Findings from the multiple methods school stress and support study. Child Indicators Research, 8, 403–423.doi:10.1007/s12187-014-9245-7

Pabst O. (2012). New concepts in the generation and functions of IgA. Nature Reviews Immunology, 12, 821–832.

Pagliaccio D. Luby J. L. Bogdan R. Agrawal A. Gaffrey M. S. Belden A. C. … Barch D. M. (2014). Stress-system genes and life stress predict cortisol levels and amygdala and hippocampal volumes in children. Neuropsychopharmacology, 39, 1245–1253. doi:10.1038/npp.2013.327

Palmer F. B. Anand K. J. Graff J. C. Murphy L. E. Qu Y. Völgyi E. … Tylavsky F. A. (2013). Early adversity, socioemotional development, and stress in urban 1-year-old children. Journal of Pediatrics, 163, 1733–1739.e1.

Panagiotakopoulos L. Neigh G. N. (2014). Development of the HPA axis: Where and when do sex differences manifest? Frontiers in Neuroendocrinology, 35, 285–302. doi:10.1016/j.yfrne.2014.03.002

Patel V. DeSouza N. Rodrigues M. (2003). Postnatal depression and infant growth and development in low income countries: A cohort study from Goa, India. Archives of Disease in Childhood, 88, 34–37.

Peaston R. T. Weinkove C. (2004). Measurement of catecholamines and their metabolites. Annals of Clinical Biochemistry, 41, 17–38. doi:10.1258/000456304322664663

Pedersen J. M. Lund R. Andersen I. Clark A. J. Prescott E. Rod N. H. (2016). Psychosocial risk factors for the metabolic syndrome: A prospective cohort study. International Journal of Cardiology, 215, 41–46. doi:10.1016/j.ijcard.2016.04.076

Pervanidou P. Chrousos G. P. (2012). Metabolic consequences of stress during childhood and adolescence. Metabolism, 61, 611–619.

Pervanidou P. Margeli A. Lazaropoulou C. Papassotiriou I. Chrousos G. P. (2008). The immediate and long-term impact of physical and/or emotional stress from motor vehicle accidents on circulating stress hormones and adipo-cytokines in children and adolescents. Stress, 11, 438–447. doi:10.1080/10253890801890622

Phelps E. A. LeDoux J. E. (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 48, 175–187. doi:10.1016/j.neuron.2005.09.025

Pirkola J. Vääräsmäki M. Ala-Korpela M. Bloigu A. Canoy D. Hartikainen A.-L. … Pouta A. (2010). Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle. American Journal of Epidemiology, 171, 72–82. doi:10.1093/aje/kwp320

Potasz C. Varela M. J. V. D. Carvalho L. C. D. Prado L. F. D. Prado G. F. D. (2013). Effect of play activities on hospitalized children’s stress: A randomized clinical trial. Scandinavian Journal of Occupational Therapy, 20, 71–79. doi:10.3109/11038128.2012.729087

Powell L. M. Wada R. Krauss R. C. Wang Y. (2012). Ethnic disparities in adolescent body mass index in the United States: The role of parental socioeconomic status and economic contextual factors. Social Science and Medicine, 75, 469–476. doi:10.1016/j.socscimed.2012.03.019

Pretty C. O’Leary D. D. Cairney J. Wade T. J. (2013). Adverse childhood experiences and the cardiovascular health of children: A cross-sectional study. BMC Pediatrics, 13, 208. doi:10.1186/1471-2431-13-208

Priest N. C. Paradies Y. C. Gunthorpe W. Cairney S. J. Sayers S. M. (2011). Racism as a determinant of social and emotional wellbeing for aboriginal Australian youth. Medical Journal of Australia, 194, 546–550.

Pumprla J. Howorka K. Groves D. Chester M. Nolan J. (2002). Functional assessment of heart rate variability: Physiological basis and practical applications. International Journal of Cardiology, 84, 1–14.

Rao U. Chen L.-A. Bidesi A. S. Shad M. U. Thomas M. A. Hammen C. L. (2010). Hippocampal changes associated with early-life adversity and vulnerability to depression. Biological Psychiatry, 67, 357–364. doi:10.1016/j.biopsych.2009.10.017

Rao U. Hammen C. L. Poland R. E. (2010). Longitudinal course of adolescent depression: Neuroendocrine and psychosocial predictors. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 141–151. doi:10.1097/00004583-201002000-00008

Rash J. A. Campbell T. S. Letourneau N. Giesbrecht G. F. (2015). Maternal cortisol during pregnancy is related to infant cardiac vagal control. Psychoneuroendocrinology, 54, 78–89. doi:10.1016/j.psyneuen.2015.01.024

Reinhart W. H. (2003). Fibrinogen—marker or mediator of vascular disease? Vascular Medicine, 8, 211–216. doi:10.1191/1358863x03vm494ra

Riis J. L. Granger D. A. DiPietro J. A. Bandeen-Roche K. Johnson S. B. (2015). Salivary cytokines as a minimally-invasive measure of immune functioning in young children: Correlates of individual differences and sensitivity to laboratory stress. Developmental Psychobiology, 57, 153–167.

Riis J. L. Granger D. A. Minkovitz C. S. Bandeen-Roche K. DiPietro J. A. Johnson S. B. (2016). Maternal distress and child neuroendocrine and immune regulation. Social Science and Medicine, 151, 206–214. doi:10.1016/j.socscimed.2015.12.043

Rippe R. C. A. Noppe G. Windhorst D. A. Tiemeier H. van Rossum E. F. C. Jaddoe V. W. V. … van den Akker E. L. T. (2016). Splitting hair for cortisol? Associations of socio-economic status, ethnicity, hair color, gender and other child characteristics with hair cortisol and cortisone. Psychoneuroendocrinology, 66, 56–64. doi:10.1016/j.psyneuen.2015.12.016

Rivkees S. A. (2003). Developing circadian rhythmicity in infants. Pediatrics, 112, 373–381.

Rizza R. A. Mandarino L. J. Gerich J. E. (1982). Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action. Journal of Clinical Endocrinology and Metabolism, 54, 131–138.

Rodriguez J. Huntington-Moskos L. Johnson A. Williams S. Gulledge E. Feeley C. Rice M. (2016). Collecting biological measures for research with children and adolescents. Journal of Pediatric Health Care, 30, 279–283.

Rogosch F. A. Dackis M. N. Cicchetti D. (2011). Child maltreatment and allostatic load: Consequences for physical and mental health in children from low-income families. Development and Psychopathology, 23, 1107–1124. doi:10.1017/S0954579411000587

Romeo R. D. (2013). The teenage brain: The stress response and the adolescent brain. Current Directions in Psychological Science, 22, 140–145. doi:10.1177/0963721413475445

Rotenberg S. McGrath J. J. (2016). Inter-relation between autonomic and HPA axis activity in children and adolescents. Biological Psychology, 117, 16–25. doi:10.1016/j.biopsycho.2016.01.015

Rozanski A. Blumenthal J. A. Kaplan J. (1999). Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation, 99, 2192–2217.

Russell E. Koren G. Rieder M. Van Uum S. (2012). Hair cortisol as a biological marker of chronic stress: Current status, future directions and unanswered questions. Psychoneuroendocrinology, 37, 589–601.

Ruttle P. L. Klein M. H. Slattery M. J. Kalin N. H. Armstrong J. M. Essex M. J. (2014). Adolescent adrenocortical activity and adiposity: Differences by sex and exposure to early maternal depression. Psychoneuroendocrinology, 47, 68–77. doi:10.1016/j.psyneuen.2014.04.025

Saltzman K. M. Holden G. W. Holahan C. J. (2005). The psychobiology of children exposed to marital violence. Journal of Clinical Child and Adolescent Psychology, 34, 129–139.

Sapolsky R. M. (1996). Stress, glucocorticoids, and damage to the nervous system: The current state of confusion. Stress, 1, 1–19.

Sapolsky R. M. (2002). Endocrinology of the stress-response. In Becker J. B. Breedlove S. M. Crews D. McCarthy M. M. (Eds.), Behavioral endocrinology (pp. 409–450). Cambridge, MA: MIT Press.

Sapolsky R. M. Romero L. M. Munck A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21, 55–89. doi:10.1210/er.21.1.55

Sauvé B. Koren G. Walsh G. Tokmakejian S. Van Uum S. H. (2007). Measurement of cortisol in human hair as a biomarker of systemic exposure. Clinical & Investigative Medicine, 30, 183–191.

Scheller J. Chalaris A. Schmidt-Arras D. Rose-John S. (2011). The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochimica et Biophysica Acta—Molecular Cell Research, 1813, 878–888. doi:10.1016/j.bbamcr.2011.01.034

Sesso M. L. T. Borges M. C. L. Ferriani V. P. L. Geraldo-Martins V. R. Rodrigues D. B. R. Nogueira R. D. (2014). Prospective evaluation of cytokine in saliva of preterm and fullterm neonates. Immunobiology, 219, 830–835. doi:10.1016/j.imbio.2014.07.015

Shonkoff J. P. Garner A. S. Siegel B. S. Dobbins M. I. Earls M. F. McGuinn L. ,…Committee on Early Childhood, Adoption, and Dependent Care. (2012). The lifelong effects of early childhood adversity and toxic stress. Pediatrics, 129, e232–e246.

Simmons J. G. Badcock P. B. Whittle S. L. Byrne M. L. Mundy L. Patton G. C. … Allen N. B. (2016). The lifetime experience of traumatic events is associated with hair cortisol concentrations in community-based children. Psychoneuroendocrinology, 63, 276–281. doi:10.1016/j.psyneuen.2015.10.004

Slopen N. Kubzansky L. D. Koenen K. C. (2013). Internalizing and externalizing behaviors predict elevated inflammatory markers in childhood. Psychoneuroendocrinology, 38, 2854–2862. doi:10.1016/j.psyneuen.2013.07.012

Slopen N. Kubzansky L. D. McLaughlin K. A. Koenen K. C. (2013). Childhood adversity and inflammatory processes in youth: A prospective study. Psychoneuroendocrinology, 38, 188–200. doi:10.1016/j.psyneuen.2012.05.013

Slopen N. McLaughlin K. A. Shonkoff J. P. (2014). Interventions to improve cortisol regulation in children: A systematic review. Pediatrics, 133, 312–326. doi:10.1542/peds.2013-1632

Smy L. Shaw K. Smith A. Russell E. Van Uum S. Rieder M. … Koren G. (2015). Hair cortisol as a novel biomarker of HPA suppression by inhaled corticosteroids in children. Pediatric Research, 78, 44–47.

Snider S. R. Kuchel O. (1983). Dopamine: An important neurohormone of the sympathoadrenal system. Significance of increased peripheral dopamine release for the human stress response and hypertension. Endocrine Reviews, 4, 291–309.

Sorota S. (2014). The sympathetic nervous system as a target for the treatment of hypertension and cardiometabolic diseases. Journal of Cardiovascular Pharmacology, 63, 466–476. doi:10.1097/FJC.0000000000000064

Spruill T. M. (2010). Chronic psychosocial stress and hypertension. Current Hypertension Reports, 12, 10–16.

Steptoe A. Kivimäki M. (2013). Stress and cardiovascular disease: An update on current knowledge. Annual Review of Public Health, 34, 337–354.

Strahler J. Mueller A. Rosenloecher F. Kirschbaum C. Rohleder N. (2010). Salivary α-amylase stress reactivity across different age groups. Psychophysiology, 47, 587–595.

Stumvoll M. Tataranni P. A. Stefan N. Vozarova B. Bogardus C. (2003). Glucose allostasis. Diabetes, 52, 903–909.

Surkan P. J. Kawachi I. Ryan L. M. Berkman L. F. Carvalho Vieira L. M. Peterson K. E. (2008). Maternal depressive symptoms, parenting self-efficacy, and child growth. American Journal of Public Health , 98, 125–132.

Suzuki H. Luby J. L. Botteron K. N. Dietrich R. McAvoy M. P. Barch D. M. (2014). Early life stress and trauma and enhanced limbic activation to emotionally valenced faces in depressed and healthy children. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 800–813.e10.

Tate E. B. Wood W. Liao Y. Dunton G. F. (2015). Do stressed mothers have heavier children? A meta-analysis on the relationship between maternal stress and child body mass index. Obesity Reviews, 16, 351–361. doi:10.1111/obr.12262

Taylor R. L. Machacek D. Singh R. J. (2002). Validation of a high-throughput liquid chromatography-tandem mass spectrometry method for urinary cortisol and cortisone. Clinical Chemistry, 48, 1511–1519.

Thomas C. Nightingale C. M. Donin A. S. Rudnicka A. R. Owen C. G. Sattar N. … Whincup P. H. (2012). Socio-economic position and type 2 diabetes risk factors: Patterns in UK children of south Asian, Black African-Caribbean and White European origin. PLoS One, 7 doi:10.1371/journal.pone.0032619

Tottenham N. Sheridan M. A. (2009). A review of adversity, the amygdala and the hippocampus: A consideration of developmental timing. Frontiers in Human Neuroscience, 3, 68. doi:10.3389/neuro.09.068.2009

Trainor B. C. (2011). Stress responses and the mesolimbic dopamine system: Social contexts and sex differences. Hormones and Behavior, 60, 457–469. doi:10.1016/j.yhbeh.2011.08.013

Tyrka A. R. Parade S. H. Valentine T. R. Eslinger N. M. Seifer R. (2015). Adversity in preschool-aged children: Effects on salivary interleukin-1ß. Development and Psychopathology, 27, 567–576. doi:10.1017/S0954579415000164

Ursache A. Blair C. (2015). Children’s cortisol and salivary alpha-amylase interact to predict attention bias to threatening stimuli. Physiology and Behavior, 138, 266–272. doi:10.1016/j.physbeh.2014.10.002

Vaghri Z. Guhn M. Weinberg J. Grunau R. E. Yu W. Hertzman C. (2013). Hair cortisol reflects socio-economic factors and hair zinc in preschoolers. Psychoneuroendocrinology, 38, 331–340.

van Den Berg G. Van Eijsden M. Vrijkotte T. G. M. Gemke R. J. B. J. (2012). Socioeconomic inequalities in lipid and glucose metabolism in early childhood in a population-based cohort: The ABCD-study. BMC Public Health, 12, 591. doi:10.1186/1471-2458-12-591

van Dijk A. E. van Eijsden M. Stronks K. Gemke R. J. B. J. Vrijkotte T. G. M. (2012). Prenatal stress and balance of the child’s cardiac autonomic nervous system at age 5-6 years. PLoS One, 7, e30413. doi:10.1371/journal.pone.0030413

van Dijk A. E. van Eijsden M. Stronks K. Gemke R. J. B. J. Vrijkotte T. G. M. (2015). No associations of prenatal maternal psychosocial stress with fasting glucose metabolism in offspring at 5-6 years of age. Journal of Developmental Origins of Health and Disease, 5, 361–369. doi:10.1017/S2040174414000300

Vanaelst B. Huybrechts I. Bammann K. Michels N. Vriendt T. Vyncke K. … Molnar D. (2012). Intercorrelations between serum, salivary, and hair cortisol and child—reported estimates of stress in elementary school girls. Psychophysiology, 49, 1072–1081.

Vanaelst B. Michels N. Clays E. Herrmann D. Huybrechts I. Sioen I. … De Henauw S. (2014). The association between childhood stress and body composition, and the role of stress-related lifestyle factors—cross-sectional findings from the baseline ChiBS survey. International Journal of Behavioral Medicine, 21, 292–301. doi:10.1007/s12529-013-9294-1

Vanaelst B. Michels N. De Vriendt T. Huybrechts I. Vyncke K. Sioen I. … Molnar D. (2013). Cortisone in hair of elementary school girls and its relationship with childhood stress. European Journal of Pediatrics, 172, 843–846.

Vanderas A. P. Menenakou M. Kouimtzis T. Papagiannoulis L. (1999). Urinary catecholamine levels and bruxism in children. Journal of Oral Rehabilitation, 26, 103–110.

Veldhorst M. A. Noppe G. Jongejan M. H. Kok C. B. Mekic S. Koper J. W. … van den Akker E. L. (2013). Increased scalp hair cortisol concentrations in obese children. Journal of Clinical Endocrinology & Metabolism, 99, 285–290.

Vermeer H. J. van IJzendoorn M. H. Groeneveld M. G. Granger D. A. (2012). Downregulation of the immune system in low-quality child care: The case of Secretory Immunoglobulin A (SIgA) in toddlers. Physiology and Behavior, 105, 161–167. doi:10.1016/j.physbeh.2011.08.017

Vignali D. A. A. (2000). Multiplexed particle-based flow cytometric assays. Journal of Immunological Methods, 243, 243–255. doi:10.1016/S0022-1759(00)00238-6

Vining R. F. McGinley R. A. Maksvytis J. J. Ho K. Y. (1983). Salivary cortisol: A better measure of adrenal cortical function than serum cortisol. Annals of Clinical Biochemistry, 20, 329–335.

Vitaliano P. P. Scanlan J. M. Zhang J. Savage M. V. Hirsch I. B. Siegler I. C. (2002). A path model of chronic stress, the metabolic syndrome, and coronary heart disease. Psychosomatic Medicine, 64, 418–435.

Vliegenthart J. Noppe G. van Rossum E. F. C. Koper J. W. Raat H. van den Akker E. L. T. (2016). Socioeconomic status in children is associated with hair cortisol levels as a biological measure of chronic stress. Psychoneuroendocrinology, 65, 9–14. doi:10.1016/j.psyneuen.2015.11.022

Wahlstrom D. White T. Luciana M. (2010). Neurobehavioral evidence for changes in dopamine system activity during adolescence. Neuroscience & Biobehavioral Reviews, 34, 631–648.

Watamura S. E. Coe C. L. Laudenslager M. L. Robertson S. S. (2010). Child care setting affects salivary cortisol and antibody secretion in young children. Psychoneuroendocrinology, 35, 1156–1166. doi:10.1016/j.psyneuen.2010.02.001

Waynforth D. (2007). The influence of parent-infant cosleeping, nursing, and childcare on cortisol and SIgA immunity in a sample of British children. Developmental Psychobiology, 49, 640–648. doi:10.1002/dev.20248

Weigensberg M. J. Toledo-Corral C. M. Goran M. I. (2008). Association between the metabolic syndrome and serum cortisol in overweight Latino youth. Journal of Clinical Endocrinology and Metabolism, 93, 1372–1378. doi:10.1210/jc.2007-2309

Wener M. H. Daum P. R. McQuillan G. M. (2000). The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration. Journal of Rheumatology, 27, 2351–2359.

Willemen A. M. Schuengel C. Koot H. M. (2009). Physiological regulation of stress in referred adolescents: The role of the parent-adolescent relationship. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50, 482–490. doi:10.1111/j.1469-7610.2008.01982.x

Wilson D. K. Kliewer W. Plybon L. Sica D. A. (2000). Socioeconomic status and blood pressure reactivity in healthy Black adolescents. Hypertension, 35, 496–500.

Winning A. Glymour M. M. McCormick M. C. Gilsanz P. Kubzansky L. D. (2015 Psychological distress across the life course and cardiometabolic risk findings from the 1958 British birth cohort study. Journal of the American College of Cardiology, 66, 1577–1586. doi:10.1016/j.jacc.2015.08.021

Yasuma F. Hayano J. (2004). Respiratory sinus arrhythmia: Why does the heartbeat synchronize with respiratory rhythm? Chest Journal, 125, 683–690.

Zahir N. Heyman M. B. Wojcicki J. M. (2013). No association between childcare and obesity at age 4 in low-income Latino children. Pediatric Obesity, 8, E24–E28. doi:10.1111/j.20I47-6T310.2012.Y00125.x

Zhang J. Lam S.-P. Kong A. P. S. Ma R. C. W. Li S. X. Chan J. W. Y. … Wing Y.-K. (2016). Family conflict and lower morning cortisol in adolescents and adults: Modulation of puberty. Scientific Reports, 6, 22531. doi:10.1038/srep22531

Zmiri P. Rubin L. Akons H. Zion N. Shaoul R. (2011). The effect of day care attendance on infant and toddler’s growth. Acta Paediatrica, International Journal of Paediatrics, 100, 266–270. doi:10.1111/j.1651-2227.2010.01999.x