Psychological Effects of Repetitive Transcranial Magnetic Stimulation on Individuals With Methamphetamine Use Disorder: A Systematic Review and Meta-Analysis

Abstract

Objective

To evaluate the effects of rTMS on drug craving, depression, anxiety, sleep, and cognitive function in methamphetamine (MA) dependent individuals.

Data sources and methods

Randomized controlled trials (RCTs) of rTMS interventions for MA-dependent patients were searched through PubMed, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, Chongqing Vipers (VIP) and China Biomedical Literature Database (CBLD). The included literature was statistically processed using Revman 5.4, and STATA 16.0 for sensitivity and bias analysis.

Results

A total of 13 papers were included, and the results of the meta-analysis showed that rTMS was effective in reducing craving scores (SMD = −1.53, 95%CI:−2.08 ∼ −0.98, p < 0.00001), improving depression (SMD = −0.32, 95%CI:-0.58 ∼ −0.07, p = 0.01) and sleep scores (WMD = −1.26, 95%CI:−2.26 ∼ −0.27, p = 0.01), but had no effect on anxiety scores (SMD = −0.42, 95%CI:−0.88 ∼ 0.03, p = 0.07); in terms of cognitive function, there were improvements in the international shopping list task (ISL), Groton maze learning task (GML) and continuous paired association learning task (CPAL), except for no effect on the social emotional cognition task (SEC) and two back task (TWOB). Subgroup analysis showed significant differences in the effects of different intervention period on craving in MA-dependent individuals.

Conclusion

rTMS was effective in reducing MA dependent individuals' cravings, alleviating depressive symptoms, improving sleep quality and language learning, collaborative learning and executive skills. Due to the small sample size of this study, a large number of RCTs are needed to validate this.

Keywords

repetitive transcranial magnetic stimulation methamphetamine psychological meta-analysis

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References

Amiaz

Levy

Vainiger

Grunhaus

Zangen

(2009). Repeated high-frequency transcranial magnetic stimulation over the dorsolateral prefrontal cortex reduces cigarette craving and consumption. Addiction (Abingdon, England), 104(4), 653–660. https://doi.org/10.1111/j.1360-0443.2008.02448.x

Camprodon

J. A.

Martínez-Raga

Alonso-Alonso

Shih

M.-C.

Pascual-Leone

(2007). One session of high frequency repetitive transcranial magnetic stimulation (rTMS) to the right prefrontal cortex transiently reduces cocaine craving. Drug and Alcohol Dependence, 86(1), 91–94. https://doi.org/10.1016/j.drugalcdep.2006.06.002

Cao

Deng

Guo

(2018). Response and remission rates following high-frequency vs. Low-frequency repetitive transcranial magnetic stimulation (rTMS) over right DLPFC for treating major depressive disorder (MDD): A meta-analysis of randomized, double-blind trials. Frontiers in Psychiatry, 9, 413. https://doi.org/10.3389/fpsyt.2018.00413

Chen

Classen

Gerloff

Celnik

Wassermann

E. M.

Hallett

Cohen

L. G.

(1997). Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology, 48(5), 1398–1403. https://doi.org/10.1212/wnl.48.5.1398

Chen

Jiang

Zhong

Meng

Duan

Zhang

Xiao

Song

Zhao

(2020). Cognitive and emotional predictors of real versus sham repetitive transcranial magnetic stimulation treatment response in methamphetamine use disorder. Journal of Psychiatric Research, 126, 73–80. https://doi.org/10.1016/j.jpsychires.2020.05.007

Chen

Jiang

Tan

Zhang

Zhong

Zhao

(2020). The exploration of optimized protocol for repetitive transcranial magnetic stimulation in the treatment of methamphetamine use disorder: A randomized sham-controlled study. EBioMedicine, 60, Article 103027. https://doi.org/10.1016/j.ebiom.2020.103027

Cho

S. S.

Strafella

A. P.

(2009). rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex. PLoS One, 4(8), Article e6725. https://doi.org/10.1371/journal.pone.0006725

Diana

Raij

Melis

Nummenmaa

Leggio

Bonci

(2017). Rehabilitating the addicted brain with transcranial magnetic stimulation. Nature Reviews. Neuroscience, 18(11), 685–693. https://doi.org/10.1038/nrn.2017.113

Dinur-Klein

Dannon

Hadar

Rosenberg

Roth

Kotler

Zangen

(2014). Smoking cessation induced by deep repetitive transcranial magnetic stimulation of the prefrontal and insular cortices: A prospective, randomized controlled trial. Biological Psychiatry, 76(9), 742–749. https://doi.org/10.1016/j.biopsych.2014.05.020

10.

Egger

Smith

G. D.

Phillips

A. N.

(1997). Meta-analysis: Principles and procedures. BMJ (Clinical Research ed.), 315(7121), 1533–1537. https://doi.org/10.1136/bmj.315.7121.1533

11.

Farrell

Martin

N. K.

Stockings

Bórquez

Cepeda

J. A.

Degenhardt

Ali

Tran

L. T.

Rehm

Torrens

Shoptaw

McKetin

(2019). Responding to global stimulant use: Challenges and opportunities. Lancet (London, England), 394(10209), 1652–1667. https://doi.org/10.1016/S0140-6736(19)32230-5

12.

Feng

(2018). A study of rTMS on cognitive functioning and craving in methamphetamine dependent individuals [Master, Bengbu Medical College].

13.

Fitzgerald

P. B.

(2011). The emerging use of brain stimulation treatments for psychiatric disorders. The Australian and New Zealand Journal of Psychiatry, 45(11), 923–938. https://doi.org/10.3109/00048674.2011.615294

14.

Gardner

E. L.

(2011). Addiction and brain reward and antireward pathways. Advances In Psychosomatic Medicine, 30, 22–60. https://doi.org/10.1159/000324065

15.

Gorelick

D. A.

Zangen

George

M. S.

(2014). Transcranial magnetic stimulation in the treatment of substance addiction. Annals of the New York Academy of Sciences, 1327, 79–93. https://doi.org/10.1111/nyas.12479

16.

Hanlon

C. A.

Kearney-Ramos

Dowdle

L. T.

Hamilton

DeVries

Mithoefer

Austelle

Lench

D. H.

Correia

Canterberry

Smith

J. P.

Brady

K. T.

George

M. S.

(2017). Developing repetitive transcranial magnetic stimulation (rTMS) as a treatment tool for cocaine use disorder: A series of six translational studies. Current Behavioral Neuroscience Reports, 4(4), 341–352. https://doi.org/10.1007/s40473-017-0135-4

17.

(2019). Repetitive transcranial magnetic stimulation as an intervention for inhibitory control of impairment in methamphetamine addicts [Master, Liaoning Normal University].

18.

Higgins

J. P.

Thomas

Chandler

Cumpston

Page

M. J.

Welch

V. A.

(2019). Cochrane handbook for systematic reviews of interventions. John Wiley & Sons.

19.

Hoffman

R. E.

Cavus

(2002). Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. The American Journal of Psychiatry, 159(7), 1093–1102. https://doi.org/10.1176/appi.ajp.159.7.1093

20.

Jansen

J. M.

Daams

J. G.

Koeter

M. W. J.

Veltman

D. J.

van den Brink

Goudriaan

A. E.

(2013). Effects of non-invasive neurostimulation on craving: A meta-analysis. Neuroscience and Biobehavioral Reviews, 37(10 Pt 2), 2472–2480. https://doi.org/10.1016/j.neubiorev.2013.07.009

21.

Kammer

Spitzer

(2012). Brain stimulation in psychiatry: Methods and magnets, patients and parameters. Current Opinion in Psychiatry, 25(6), 535–541. https://doi.org/10.1097/YCO.0b013e328358df8c

22.

Leng

(2019). Effects of repetitive transcranial magnetic stimulation on psychological craving and cognitive functioning in methamphetamine addicts [Master, Liaoning Normal University].

23.

Malcolm

R. J.

Huebner

Hanlon

C. A.

Taylor

J. J.

Brady

K. T.

George

M. S.

See

R. E.

(2013). Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: A preliminary study. Drug and Alcohol Dependence, 133(2), 641–646. https://doi.org/10.1016/j.drugalcdep.2013.08.012

24.

Liang

Wang

Yuan

T.-F.

(2018). Targeting withdrawal symptoms in men addicted to methamphetamine with transcranial magnetic stimulation: A randomized clinical trial. JAMA Psychiatry, 75(11), 1199–1201. https://doi.org/10.1001/jamapsychiatry.2018.2383

25.

Liu

Jiao

Gao

Cheng

Wang

(2020). Efficacy and safety of repetitive transcranial magnetic stimulation in methamphetamine dependent patients. Neurological Disorders and Mental Health, 20(11), 812-816.

26.

Liu

Shen

Cao

Chen

Yang

Yuan

T.-F.

(2017). Either at left or right, both high and low frequency rTMS of dorsolateral prefrontal cortex decreases cue induced craving for methamphetamine. The American Journal on Addictions, 26(8), 776–779. https://doi.org/10.1111/ajad.12638

27.

Liu

(2019). Exploration of a protocol for the treatment of female methamphetamine addicts with repetitive transcranial magnetic stimulation [Master, Nanjing Normal University].

28.

Liu

Zhao

Shen

Liu

Tang

Zhang

Luo

Yuan

T.-F.

(2020). The effects of DLPFC-targeted repetitive transcranial magnetic stimulation on craving in male methamphetamine patients. Clinical and Translational Medicine, 10(2), Article e48. https://doi.org/10.1002/ctm2.48

29.

Sun

(2019). Effects of non-invasive brain stimulation on stimulant craving in users of cocaine, amphetamine, or methamphetamine: A systematic review and meta-analysis. Frontiers in Neuroscience, 13, 1095. https://doi.org/10.3389/fnins.2019.01095

30.

Mahoney

J. J.

Hanlon

C. A.

Marshalek

P. J.

Rezai

A. R.

Krinke

(2020). Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment. Journal of the Neurological Sciences, 418, Article 117149. https://doi.org/10.1016/j.jns.2020.117149

31.

McCalley

D. M.

Lench

D. H.

Doolittle

J. D.

Imperatore

J. P.

Hoffman

Hanlon

C. A.

(2021). Determining the optimal pulse number for theta burst induced change in cortical excitability. Scientific Reports, 11(1), 8726. https://doi.org/10.1038/s41598-021-87916-2

32.

Mishra

B. R.

Praharaj

S. K.

Katshu

M. Z. U. H.

Sarkar

Nizamie

S. H.

(2015). Comparison of anticraving efficacy of right and left repetitive transcranial magnetic stimulation in alcohol dependence: A randomized double-blind study. The Journal of Neuropsychiatry and Clinical Neurosciences, 27(1), e54–e59. https://doi.org/10.1176/appi.neuropsych.13010013

33.

Moreno-Rius

Miquel

(2017). The cerebellum in drug craving. Drug and Alcohol Dependence, 173, 151–158. https://doi.org/10.1016/j.drugalcdep.2016.12.028

34.

Moretti

Poh

E. Z.

Rodger

(2020). rTMS-induced changes in glutamatergic and dopaminergic systems: Relevance to cocaine and methamphetamine use disorders. Frontiers in Neuroscience, 14, 137. https://doi.org/10.3389/fnins.2020.00137

35.

Nettekoven

Volz

L. J.

Kutscha

Pool

E.-M.

Rehme

A. K.

Eickhoff

S. B.

Fink

G. R.

Grefkes

(2014). Dose-dependent effects of theta burst rTMS on cortical excitability and resting-state connectivity of the human motor system. The Journal of Neuroscience : The Official Journal of the Society For Neuroscience, 34(20), 6849–6859. https://doi.org/10.1523/JNEUROSCI.4993-13.2014

36.

Newton

T. F.

Kalechstein

A. D.

Duran

Vansluis

Ling

(2004). Methamphetamine abstinence syndrome: Preliminary findings. The American Journal on Addictions, 13(3), 248–255. https://doi.org/10.1080/10550490490459915

37.

Ozburn

A. R.

Janowsky

A. J.

Crabbe

J. C.

(2015). Commonalities and distinctions among mechanisms of addiction to alcohol and other drugs. Alcoholism, Clinical and Experimental Research, 39(10), 1863–1877. https://doi.org/10.1111/acer.12810

38.

Page

M. J.

McKenzie

J. E.

Bossuyt

P. M.

Boutron

Hoffmann

T. C.

Mulrow

C. D.

Shamseer

Tetzlaff

J. M.

Akl

E. A.

Brennan

S. E.

Chou

Glanville

Grimshaw

J. M.

Hróbjartsson

Lalu

M. M.

Loder

E. W.

Mayo-Wilson

McDonald

Moher

(2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

39.

Pignatelli

Bonci

(2015). Role of dopamine neurons in reward and aversion: A synaptic plasticity perspective. Neuron, 86(5), 1145–1157. https://doi.org/10.1016/j.neuron.2015.04.015

40.

Politi

Fauci

Santoro

Smeraldi

(2008). Daily sessions of transcranial magnetic stimulation to the left prefrontal cortex gradually reduce cocaine craving. The American Journal on Addictions, 17(4), 345–346. https://doi.org/10.1080/10550490802139283

41.

Preston

K. L.

Kowalczyk

W. J.

Phillips

K. A.

Jobes

M. L.

Vahabzadeh

Lin

J.-L.

Mezghanni

Epstein

D. H.

(2018). Exacerbated craving in the presence of stress and drug cues in drug-dependent patients. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 43(4), 859–867. https://doi.org/10.1038/npp.2017.275

42.

Song

Zilverstand

Gui

H.-J.

Zhou

(2019). Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis. Brain Stimulation, 12(3), 606–618. https://doi.org/10.1016/j.brs.2018.12.975

43.

Song

Zilverstand

Gui

Pan

Zhou

(2022). Reducing craving and consumption in individuals with drug addiction, obesity or overeating through neuromodulation intervention: A systematic review and meta-analysis of its follow-up effects. Addiction (Abingdon, England), 117(5), 1242–1255. https://doi.org/10.1111/add.15686

44.

Strafella

A. P.

Paus

Barrett

Dagher

(2001). Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. The Journal of Neuroscience : The Official Journal of the Society For Neuroscience, 21(15), RC157. https://doi.org/10.1523/jneurosci.21-15-j0003.2001

45.

Strafella

A. P.

Paus

Fraraccio

Dagher

(2003). Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain : A Journal of Neurology, 126(Pt 12), 2609-2615. https://doi.org/10.1093/brain/awg268

46.

(2017). Exploring the efficacy and mechanisms of repetitive transcranial magnetic stimulation in the treatment of amphetamine-type stimulant addiction [Doctor, Shanghai Jiao Tong University].

47.

Chen

Jiang

Zhong

Xiao

Song

Zhao

(2020). Intermittent theta burst transcranial magnetic stimulation for methamphetamine addiction: A randomized clinical trial. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 31, 158–161. https://doi.org/10.1016/j.euroneuro.2019.12.114

48.

Chen

Zhong

Jiang

Xiao

Wang

Zhao

(2020). γ-Aminobutyric acid and glutamate/glutamine alterations of the left prefrontal cortex in individuals with methamphetamine use disorder: A combined transcranial magnetic stimulation-magnetic resonance spectroscopy study. Annals of Translational Medicine, 8(6), 347. https://doi.org/10.21037/atm.2020.02.95

49.

Liu

Yin

Chen

Zhong

Jiang

Wang

Xiao

Zeljic

Wang

Zhao

(2020). Neuroplastic changes in resting-state functional connectivity after rTMS intervention for methamphetamine craving. Neuropharmacology, 175, 108177. https://doi.org/10.1016/j.neuropharm.2020.108177

50.

Zhong

Gan

Wang

Han

Chen

Ruan

Zhu

Jiang

Zhao

(2017). High frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex for methamphetamine use disorders: A randomised clinical trial. Drug and Alcohol Dependence, 175, 84–91. https://doi.org/10.1016/j.drugalcdep.2017.01.037

51.

Terraneo

Leggio

Saladini

Ermani

Bonci

Gallimberti

(2016). Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study. European Neuropsychopharmacology : The Journal of the European College of Neuropsychopharmacology, 26(1), 37-44. https://doi.org/10.1016/j.euroneuro.2015.11.011

52.

UNODC (2022). Booklet-4 drug market trends: Cocaine, amphetamine -type stimulants. https://www.unodc.org/unodc/en/data-and-analysis/wdr-2021_booklet-4.html

53.

Volkow

N. D.

Koob

G. F.

McLellan

A. T.

(2016). Neurobiologic advances from the brain disease model of addiction. The New England Journal of Medicine, 374(4), 363-371. https://doi.org/10.1056/NEJMra1511480

54.

Wang

(2019). Effects of repetitive transcranial magnetic stimulation on attentional bias and psychological craving in methamphetamine dependent individuals [Master, Bengbu Medical College].

55.

Yuan

Liu

Liang

Cao

Lucas

M. V.

Yuan

T.-F.

(2020). Effect of low-frequency repetitive transcranial magnetic stimulation on impulse inhibition in abstinent patients with methamphetamine addiction: A randomized clinical trial. JAMA Network Open, 3(3), Article e200910. https://doi.org/10.1001/jamanetworkopen.2020.0910

56.

Zhang

J. J. Q.

Fong

K. N. K.

Ouyang

R.-G.

Siu

A. M. H.

Kranz

G. S.

(2019). Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence: A systematic review and meta-analysis. Addiction (Abingdon, England), 114(12), 2137–2149. https://doi.org/10.1111/add.14753

57.

Ziemann

Paulus

Nitsche

M. A.

Pascual-Leone

Byblow

W. D.

Berardelli

Siebner

H. R.

Classen

Cohen

L. G.

Rothwell

J. C.

(2008). Consensus: Motor cortex plasticity protocols. Brain Stimulation, 1(3), 164–182. https://doi.org/10.1016/j.brs.2008.06.006

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