Pleomorphic Adenocarcinoma of the Ciliary Epithelium: A Clinicopathological,Immunohistochemical,Ultrastructural,Dna-Ploidy and Comparative Genomic Hybridization Analysis of an Unusual Case
Restricted accessAnnouncementFirst published online 2002
Pleomorphic Adenocarcinoma of the Ciliary Epithelium: A Clinicopathological,Immunohistochemical,Ultrastructural,Dna-Ploidy and Comparative Genomic Hybridization Analysis of an Unusual Case
To describe detailed phenotypic and genotypic analysis of a pleomorphic adenocarcinoma of the ciliary epithelium (CE).
Case Report
An 86-year-old white woman developed an enlarging mass protruding from her previously eviscerated left eye 2 months postoperatively. Based on light and ultrastructural microscopy, the final diagnosis was a pleomorphic adenocarcinoma of the ciliary epithelium (CE).
Discussion
Cell proliferation indices confirmed the unusually rapid growth rate of this tumor; the peridiploid DNA content might explain the relatively low incidence of distant metastases. An imbalance o the chromosome 6 was also found by Comparative Genomic Hybridization (CGH).
ShieldsJ.A., EagleR.C., ShieldsC.L., De PotterP.Acquired neoplasm of the nonpigmented ciliary epithelium (adenoma and adenocarcinoma). Ophthalmology1996; 103: 2007–16.
2.
GrossniklausH.E., ZimmermanL.E., KachemerM.L.Pleomorphic adenocarcinima of the ciliary body. Ophthalmology1990; 97: 763–8.
3.
LaverN., HidayatA., CroxattoJ.O.Pleomorphic adenocarcinomas of the ciliary epithelium: immunohistochemical and ultrastructural features of 12 cases. Ophthalmology1999; 106: 103–10.
4.
GrahamR., GrayT.Electron microscopy 2: practical procedures. In: BancroftJ.D., StevensA., eds. Theory and Practice of Histological Techniques.4th ed.New York: Churchill-Livingstone, 1996.
5.
MeyerJ.S.The cell-proliferative index. Cancer Invest1990; 8: 247–9.
6.
MarchevskyA., BartelsP.H.Image Analysis, A Primer for Pathologists.New York: Raven Press; 1994.
7.
ChangM., ShieldsJ.A., WatchelD.L.Adenoma of the pigment epithelium of the ciliary body simulating a malignant melanoma. Am J Ophthalmol1979; 88: 40–4.
8.
CroxattoJ.O., ZimmermanL.E.Malignant nonpigmented intraocular tumors of neuroectodermal origin in adults. A review of 21 cases. In: SpencerH., ed. Ophthalmic Pathology3rd ed.Philadelphia: WB Saunders1985; 1260–2.
9.
MaurielloJ.A.Jr., TelloC., KishoreK., HidayatA.A.Carcinoma of the ciliary epithelium presenting as orbital cellulities. Orbit1996; 15: 47–51.
