To compare enhanced depth imaging in swept-source optical coherence tomography and non–enhanced depth imaging optical coherence tomography in their ability to capture choroidal and scleral details.
Methods
Averaged foveal B-Scans were obtained from 40 eyes of 20 healthy volunteers by swept-source optical coherence tomography with and without enhanced depth imaging. Visibility and contrast of vascular details within the choroid, choroidoscleral junction, and sclera were evaluated by masked readers using an ordinal scoring scale. Outcomes were analyzed using the Wilcoxon signed rank-sum test.
Results
Visibility of the choroidal vascular details (Z = 5.94, p < .001), the choroidoscleral junction (Z = 5.85, p < .001), and the sclera (Z = 6.80, p < .001) was significantly higher with enhanced depth imaging than with non–enhanced depth imaging swept-source optical coherence tomography. Similarly, image contrast was significantly higher with enhanced depth imaging than with non–enhanced depth imaging swept-source optical coherence tomography for the choroidal vascular details (Z = 9.47, p < .001), for the choroidoscleral junction (Z = 9.28, p < .001), and for the sclera (Z = 9.42, p < .001).
Conclusion
Enhanced depth imaging applied to swept-source optical coherence tomography–averaged foveal B-scans enhances visualization of the choroidal details, of the choroidoscleral junction, and of the sclera. This novel modality can easily be implemented in clinics and could improve our understanding of conditions involving the choroid or the sclera.
MrejenSSpaideRF.Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol2013; 58(5): 387–429.
2.
SpaideRF.Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration. Am J Ophthalmol2009; 147(4): 644–652.
3.
MargolisRSpaideRF.A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol2009; 147(5): 811–815.
LaviersHZambarakjiH.Enhanced depth imaging-OCT of the choroid: a review of the current literature. Graefes Arch Clin Exp Ophthalmol2014; 252(12): 1871–1883.
6.
RegatieriCVBranchiniLFujimotoJG, et al. Choroidal imaging using spectral-domain optical coherence tomography. Retina (Philadelphia, Pa)2012; 32(5): 865–876.
CopeteSFlores-MorenoIMonteroJA, et al. Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes. Br J Ophthalmol2014; 98(3): 334–338.
9.
AdhiMLiuJJQaviAH, et al. Enhanced visualization of the choroido-scleral interface using swept-source OCT. Ophthalmic Surg Lasers Imaging Retina2013; 44(Suppl. 6): S40–S42.
10.
HuberRAdlerDCSrinivasanVJ, et al. Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second. Opt Lett2007; 32(14): 2049–2051.
11.
AdhiMLiuJJQaviAH, et al. Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography. Am J Ophthalmol2014; 157(6): 1272.e1–1281.e1.
12.
LimLSCheungGLeeSY.Comparison of spectral domain and swept-source optical coherence tomography in pathological myopia. Eye (Lond)2014; 28(4): 488–491.
13.
MatsuoYSakamotoTYamashitaT, et al. Comparisons of choroidal thickness of normal eyes obtained by two different spectral-domain OCT instruments and one swept-source OCT instrument. Invest Ophthalmol Vis Sci2013; 54(12): 7630–7636.
14.
TanCSChanJCCheongKX, et al. Comparison of retinal thicknesses measured using swept-source and spectral-domain optical coherence tomography devices. Ophthalmic Surg Lasers Imaging Retina2015; 46(2): 172–179.
15.
TanCSNgoWKCheongKX.Comparison of choroidal thicknesses using swept source and spectral domain optical coherence tomography in diseased and normal eyes. Br J Ophthalmol2015; 99(3): 354–358.
16.
TingDSCheungGCLimLS, et al. Comparison of swept source optical coherence tomography and spectral domain optical coherence tomography in polypoidal choroidal vasculopathy. Clin Exp Ophthalmol2015; 43: 815–819.
17.
ZhengKLiuBHuangC, et al. Experimental confirmation of potential swept source optical coherence tomography performance limitations. Appl Opt2008; 47(33): 6151–6158.
18.
LiuBBrezinskiME.Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography. J Biomed Opt2007; 12(4): 044007.
19.
WaldsteinSMFaatzHSzimacsekM, et al. Comparison of penetration depth in choroidal imaging using swept source vs spectral domain optical coherence tomography. Eye (Lond)2015; 29(3): 409–415.
20.
LopillyParkHYLeeNYChoiJA, et al. Measurement of scleral thickness using swept-source optical coherence tomography in patients with open-angle glaucoma and myopia. Am J Ophthalmol2014; 157(4): 876–884.
21.
OhsugiHIkunoYOshimaK, et al. Morphologic characteristics of macular complications of a dome-shaped macula determined by swept-source optical coherence tomography. Am J Ophthalmol2014; 158(1): 162.e1–170.e1.
22.
FilloyACaminalJMAriasL, et al. Swept source optical coherence tomography imaging of a series of choroidal tumours. Can J Ophthalmol2015; 50(3): 242–248.
23.
MichalewskaZMichalewskiJNawrockaZ, et al. Suprachoroidal layer and suprachoroidal space delineating the outer margin of the choroid in swept-source optical coherence tomography. Retina2015; 35(2): 244–249.
24.
GuBLiuJLiX, et al. Real-time monitoring of suprachoroidal space (SCS) following SCS injection using ultra-high resolution optical coherence tomography in guinea pig eyes. Invest Ophthalmol Vis Sci2015; 56(6): 3623–3634.
25.
HamzahFShinojimaAMoriR, et al. Choroidal thickness measurement by enhanced depth imaging and swept-source optical coherence tomography in central serous chorioretinopathy. BMC Ophthalmol2014; 14: 145.
26.
SpaideRFRyanEHJr.Loculation of fluid in the posterior choroid in eyes with central serous chorioretinopathy. Am J Ophthalmol2015; 160: 1211–1216.
27.
KimJHChangYSKimJW, et al. Imaging suprachoroidal layer in exudative age-related macular degeneration. Curr Eye Res2015; 41: 715–720.
28.
BoonarphaNZhengYStangosAN, et al. Standardization of choroidal thickness measurements using enhanced depth imaging optical coherence tomography. Int J Ophthalmol2015; 8(3): 484–491.
29.
LimFPLohBKCheungCM, et al. Evaluation of focal choroidal excavation in the macula using swept-source optical coherence tomography. Eye (Lond)2014; 28(9): 1088–1094.
30.
WilloughbyASVuongVSCunefareD, et al. Choroidal changes after suprachoroidal injection of triamcinolone acetonide in eyes with macular edema secondary to retinal vein occlusion. Am J Ophthalmol2018; 186: 144–151.
31.
MariacherSEbnerMJanuschowskiK, et al. Investigation of a novel implantable suprachoroidal pressure transducer for telemetric intraocular pressure monitoring. Exp Eye Res2016; 151: 54–60.
32.
AbdallahWLiWWeilandJ, et al. Implantation of multiple suprachoroidal electrode arrays in rabbits. J Curr Ophthalmol2018; 30(1): 68–73.
33.
LimoliPGVingoloEMLimoliC, et al. Regenerative therapy by suprachoroidal cell autograft in dry age-related macular degeneration: preliminary in vivo report. J Vis Exp. Epub ahead of print 12 February 2018. doi:10.3791/56469
