Abstract
Objective:
To investigate the systemic associations of central serous chorioretinopathy (CSCR) with help of clinical and biochemical investigations.
Design:
Case-control study.
Participants:
Eighty seven CSCR patients (case) and 82 Asian-Indian patients with primary non-traumatic rhegmatogenous retinal detachment (control) were recruited between July 2017 and December 2018 at a tertiary eye-care center in North India.
Methods:
The patients underwent ophthalmological examination and systemic evaluation based on history and biochemical investigations. Logistic regression was performed to identify the associations of CSCR.
Results:
The age was similar between cases and controls (36.9 ± 7.8 years vs 35.7 ± 10.8 years, p = 0.38). On univariate analysis, the significant factors with higher odds of CSCR were alcohol use (odds ratio, OR: 3.4; 95% confidence interval: 1.36–8.53), sleep disturbance (OR: 5.44; 1.76–16.8), gastroesophageal reflux (OR: 9.34; 1.15–75.50), psychological disorder (OR: 5.78; 1.24–26.97), tuberculosis history (OR: 8.2; 1.0–67.10), serum albumin: globulin ratio (AGR) > 2 (OR: 10.43; 2.33–46.57), and serum hemoglobin (per unit increase; OR: 1.35; 1.14–1.61). Although the mean blood pressure was significantly higher in cases, the distribution among various hypertension categories was not significantly different. Exogenous steroid use and morning 8 am serum cortisol levels were not significantly different between the groups. On multivariable analysis, alcohol use (OR: 4.72; 1.33–16.76), sleep disturbances (OR: 5.04; 1.36–18.70), dysthyroid state (OR: 3.02; 1.04–8.74), serum AGR > 2 (OR: 14.28; 2.33–87.28), and serum hemoglobin (per unit increase; OR: 1.43; 1.13–1.81) were significant independent associations.
Conclusion:
Other than the previously described associations of CSCR like alcohol use and sleep disturbances, this study reports possible association with deranged serum protein and thyroid hormone profile. Further large-scale prospective studies need to validate these results.
Keywords
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