Abstract
Purpose
To compare the efficacy of 15-s versus 30-s intraoperative applications of 0.02% mitomycin C (MMC) in preventing corneal haze after photorefractive keratectomy (PRK) for moderate myopia.
Methods
This prospective, paired-eye study enrolled 50 patients (100 eyes) with bilateral moderate myopia (−3.00 to −6.00 D). Each patient underwent bilateral wavefront-optimized PRK. One eye was randomized to receive
Results
The median age was 25.5 years (range, 18–53). Preoperative refractive errors were symmetrical between paired eyes (P > 0.05). Postoperative corneal haze was minimal and transient. Median haze scores were 0 at all timepoints beyond the 1-week visit. Haze severity decreased significantly over time in both groups (P < 0.01), with no statistically significant differences between the 15-s and 30-s groups at any follow-up visit (P ≥ 0.08). At 6 months, the median UDVA was 0.00 logMAR in both groups (P = 1.0).
Conclusions
A 15-s intraoperative application of 0.02% MMC
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