Guidelines of the Italian Association of Pediatric Hematology and Oncology for the management of the central venous access devices in pediatric patients with onco-hematological disease

Crocoli A Tornesello A Pittiruti M , et al. Central venous access devices in pediatric malignancies: a position paper of italian association of pediatric hematology and oncology. J Vasc Access 2015; 16: 130–136.

Redfern W Braby J. Plumer’s Principles and practice of infusion therapy. Philadelphia, PA, USA: Wolters Kluwer/Lippincott Williams and Wilkins. 2014; pp. 678–742.

Gorski LA. The 2016 infusion therapy standards of practice. Home Heal Now 2016; 35: 10–18.

Carraro F Cicalese MP Cesaro S , et al. Guidelines for the use of long-term central venous catheter in children with hemato-oncological disorders. on behalf of supportive therapy working group of Italian Association of Pediatric Hematology and Oncology (AIEOP). Ann Hematol 2013; 92: 1405–1412.

Giordano P Saracco P Grassi M , et al. Recommendations for the use of long-term central venous catheter (CVC) in children with hemato-oncological disorders: management of CVC-related occlusion and CVC-related thrombosis. On behalf of the coagulation defects working group and the supportive the. Ann Hematol 2015; 94: 1765–1776.

Baskin KM Mermel LA Saad TF , et al. Evidence-based strategies and recommendations for preservation of central venous access in children. J Parenter Enter Nutr 2019; 43: 591–614.

Ullman AJ Marsh N Mihala G , et al. Complications of central venous access devices: a systematic review. Pediatrics 2015;136:e1331–e1344.

Rey C Álvarez F De La Rua V , et al. Mechanical complications during central venous cannulations in pediatric patients. Intensive Care Med 2009; 35: 1438–1443.

Mermel LA Allon M Bouza E , et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the infectious diseases society of America. Clin Infect Dis 2009; 49: 1–45.

Pinon M Bezzio S Tovo PA , et al. A prospective 7-year survey on central venous catheter-related complications at a single pediatric hospital. Eur J Pediatr 2009; 168: 1505–1512.

O’Grady NP Alexander M Burns LA , et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2011; 52: e162–e193.

Fratino G Molinari AC Parodi S , et al. Central venous catheter-related complications in children with oncological/hematological diseases: an observational study of 418 devices. Ann Oncol 2005; 16: 648–654.

Rickard CM Ullman AJ. Bloodstream infection and occlusion of central venous catheters in children. Lancet Infect Dis 2018; 18: 815–817.

Choi SW Chang L Hanauer DA , et al. Rapid reduction of central line infections in hospitalized pediatric oncology patients through simple quality improvement methods. Pediatr Blood Cancer 2013; 60: 262–269.

Secola R Azen C Lewis MA , et al. A crossover randomized prospective pilot study evaluating a central venous catheter team in reducing catheter-related bloodstream infections in pediatric oncology patients. J Pediatr Oncol Nurs 2012; 29: 307–315.

Rinke ML Chen AR Bundy DG , et al. Implementation of a central line maintenance care bundle in hospitalized pediatric oncology patients. Pediatrics 2012; 130: e996–1004.

Duffy EA Rodgers CC Shever LL , et al. Implementing a daily maintenance care bundle to prevent central line–associated bloodstream infections in pediatric oncology patients. J Pediatr Oncol Nurs 2015; 32: 394–400.

Dandoy CE Hausfeld J Flesch L , et al. Rapid cycle development of a multifactorial intervention achieved sustained reductions in central line-associated bloodstream infections in haematology oncology units at a children’s hospital: a time series analysis. BMJ Qual Saf 2016; 25: 633–643.

Rinke M Chen AR Milstone AM , et al. Bringing central-line associated bloodstream infection Prevention Home: catheter maintenance practices and beliefs of pediatric oncology patients and families. Jt Comm J Qual Patient Saf 2015; 41: 177–185.

Møller T Adamsen L. Hematologic patients’ clinical and psychosocial experiences with implanted long-term central venous catheter: self-management versus professionally controlled care. Cancer Nurs 2010; 33: 426–435.

Schiffer CA Mangu PB Wade JC , et al. Central venous catheter care for the patient with cancer: American society of clinical oncology clinical practice guideline. J Clin Oncol 2013; 31: 1357–1370.

Pittiruti M Scoppettuolo G. The GAVeCeLT manual of PICC and midline: Indications, insertion, management. Milan, Italy: Edra 2017; pp. 1–240.

Abedin S Kapoor G. Peripherally inserted central venous catheters are a good option for prolonged venous access in children with cancer. Pediatr Blood Cancer 2008; 51: 251–255.

Cotogni P Pittiruti M Barbero C , et al. Catheter-related complications in cancer patients on home parenteral nutrition. J Parenter Enter Nutr 2013; 37: 375–383.

Cotogni P Barbero C Garrino C , et al. Peripherally inserted central catheters in non-hospitalized cancer patients: 5-year results of a prospective study. Support Care Cancer 2015; 23: 403–409.

Broviac JW Cole JJ Scribner BH. A silicone rubber atrial catheter for prolonged parenteral alimentation. Surg Gynecol Obstet 1973; 136: 602–606.

Hickman RO Buckner CD Clift RA , et al. A modified right atrial catheter for access to the venous system in marrow transplant recipients. Surg Gynecol Obstet 1979; 148: 871–875.

Ares G Hunter CJ. Central venous access in children: indications, devices, and risks. Curr Opin Pediatr 2017; 29: 340–346.

Perdikaris P Petsios K Vasilatou-Kosmidis H , et al. Complications of HickmanBroviac catheters in children with malignancies. Pediatr Hematol Oncol 2008; 25: 375–384.

Blum L-V Abdel-Rahman U Klingebiel T , et al. Tunneled central venous catheters in children with malignant and chronic diseases: a comparison of open vs. percutaneous implantation. J Pediatr Surg 2017; 52: 810–812.

Dzierzega M Ossowska M Chmiel D , et al. The malposition of central venous catheters in children. Polish J Radiol 2014; 79: 275–278.

Kamra K Hammer GB. Central venous catheter placement in children: ‘How good is good enough? ’ Pediatr Anesth 2013; 23: 971–973.

Hancock-Howard R Connolly BL McMahon M , et al. Cost-effectiveness analysis of implantable venous access device insertion using interventional radiologic versus conventional operating room methods in pediatric patients with cancer. J Vasc Interv Radiol 2010; 21: 677–684.

Davidson J Paul A Patel S , et al. Central vein preservation in critical venous access. Eur J Pediatr Surg 2015; 26: 357–362.

Cameron GS. Central venous catheters for children with malignant disease: surgical issues. J Pediatr Surg 1987; 22: 702–704.

Kim S Kim Y Moon S-B. Histological changes of the unligated vein wall adjacent to the central venous catheter after open cutdown in rats. J Pediatr Surg 2015; 50: 1928–1932.

Kim S Kim Y Hwang JW , et al. Inhibitory effect of sustained perivascular delivery of paclitaxel on neointimal hyperplasia in the jugular vein after open cutdown central venous catheter placement in rats. Ann Surg Treat Res 2017; 92(2): 97.

Moureau N Lamperti M Kelly LJ , et al. Evidence-based consensus on the insertion of central venous access devices: definition of minimal requirements for training. Br J Anaesth 2013; 110: 347–356.

Avanzini S Guida E Conte M , et al. Shifting from open surgical cut down to ultrasound-guided percutaneous central venous catheterization in children: learning curve and related complications. Pediatr Surg Int 2010; 26: 819–824.

Loveday HP Wilson JA Pratt RJ , et al. Epic3: national evidence-based guidelines for preventing healthcare-associated infections in nhs hospitals in england. J Hosp Infect 2014; 86: S1–70.

Gurien LA Blakely ML Russell RT , et al. Real-time ultrasonography for placement of central venous catheters in children: a multi-institutional study. Surgery 2016; 160: 1605–1611.

Lamperti M Bodenham AR Pittiruti M , et al. International evidence-based recommendations on ultrasound-guided vascular access. Intensive Care Med 2012; 38: 1105–1117.

Pittiruti M. Ultrasound guided central vascular access in neonates, infants and children. Curr Drug Targets 2012; 13: 961–969.

Bruzoni M Slater BJ Wall J , et al. A prospective randomized trial of ultrasound- vs landmark-guided central venous access in the pediatric population. J Am Coll Surg 2013; 216: 939–943.

Dassinger MS Renaud EJ Goldin A , et al. Use of real-time ultrasound during central venous catheter placement: results of an APSA survey. J Pediatr Surg 2015; 50: 1162–1167.

Spencer TR Pittiruti M. Rapid central vein assessment (RaCeVA): a systematic, standardized approach for ultrasound assessment before central venous catheterization. J Vasc Access 2019; 20: 239–249.

Shulman RJ Smith EO Rahman S , et al. Single- vs double-lumen central venous catheters in pediatric oncology patients. Am J Dis Child 1988; 142: 893–895.

Dawson RB. PICC Zone Insertion MethodTM (ZIMTM): a systematic approach to determine the ideal insertion site for PICCs in the upper arm. J Assoc Vasc Access 2011; 16: 156–160.

Bonciarelli G Batacchi S Biffi R , et al. Gavecelt consensus statement on the correct use of totally implantable venous access devices for diagnostic radiology procedures. J Vasc Access 2011; 12: 292–305.

Burbridge B Plewes C Stoneham G , et al. Randomized clinical trial evaluating complications and complication-related removal of arm-situated power-injectable and non-power–injectable totally implanted venous access devices among cancer patients. J Vasc Interv Radiol 2018; 29: 648–656.

Journeycake JM Buchanan GR. Thrombotic complications of central venous catheters in children. Curr Opin Hematol 2003; 10: 369–374.

Matsuzaki A Suminoe A Koga Y , et al. Long-term use of peripherally inserted central venous catheters for cancer chemotherapy in children. Support Care Cancer 2006; 14: 153–160.

Skinner R Koller K McIntosh N , et al. Prevention and management of central venous catheter occlusion and thrombosis in children with cancer. Pediatr Blood Cancer 2008; 50: 826–830.

Thurman CB Abbott M Liu J , et al. Risk for health care-associated bloodstream infections in pediatric oncology patients with various malignancies. J Pediatr Oncol Nurs 2017; 34: 196–202.

Marcy P-Y. Central venous access: techniques and indications in oncology. Eur Radiol 2008; 18: 2333–2344.

Dezfulian C Lavelle J Nallamothu BK , et al. Rates of infection for single-lumen versus multilumen central venous catheters: a meta-analysis. Crit Care Med 2003; 31: 2385–2390.

Chen S-H Yang C-P Jaing T-H , et al. Catheter-related bloodstream infection with removal of catheter in pediatric oncology patients: a 10-year experience in Taiwan. Int J Clin Oncol 2012; 17: 124–130.

Gonzalez G Davidoff AM Howard SC , et al. Safety of central venous catheter placement at diagnosis of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2012; 58: 498–502.

Biasucci DG Pittiruti M Taddei A , et al. Targeting zero catheter-related bloodstream infections in pediatric intensive care unit: a retrospective matched case-control study. J Vasc Access 2018; 19: 119–24.

Omid M Rafiei MH Hosseinpour M , et al. Ultrasound-guided percutaneous central venous catheterization in infants: learning curve and related complications. Adv Biomed Res 2015; 4: 199.

Nakayama S Takahashi S Toyooka H. Curved-end guidewire for central venous cannulation in neonate. Anesth Analg 2003; 97: 917–918.

Lau CSM Chamberlain RS . Ultrasound-guided central venous catheter placement increases success rates in pediatric patients: a meta-analysis. Pediatr Res 2016; 80: 178–184.

Nardi N Wodey E Laviolle B , et al. Effectiveness and complications of ultrasound-guided subclavian vein cannulation in children and neonates. Anaesth Crit Care Pain Med 2016; 35: 209–213.

Niederhuber JE Ensminger W Gyves JW , et al. Totally implanted venous and arterial access system to replace external catheters in cancer treatment. Surgery 1982; 92: 706–712.

Raman D Sharma M Moghekar A , et al. Utilization of thoracic ultrasound for confirmation of central venous catheter placement and exclusion of pneumothorax: a novel technique in real-time application. J Intensive Care Med 2019; 34: 594–598

Lamperti M Biasucci DG Disma N , et al. European Society of Anaesthesiology guidelines on peri-operative use of ultrasound-guided for vascular access (PERSEUS vascular access). Eur J Anaesthesiol 2020; 37: 344–376.

Emoli A Cappuccio S Marche B , et al. Il protocollo “ISP” (Safe Insertion of Picc): un ‘bundle’ di otto raccomandazioni per minimizzare le complicanze legate all’impianto dei PICC [Italian]. Assist Inferm e Ric 2014; 33(2): 82–90.

Pittiruti M Scoppettuolo G Emoli A , et al. Cyanoacrylate glue and central venous access device insertion. J Assoc Vasc Access 2016; 21: 249.

Scoppettuolo G Annetta M Marano C , et al. Cyanoacrylate glue prevents early bleeding of the exit site after CVC or PICC placement. Crit Care 2013; 17: P174.

Corley A Marsh N Ullman AJ , et al. Tissue adhesive for vascular access devices: who, what, where and when? Br J Nurs 2017; 26: 4–17.

Di Puccio F Giacomarro D Mattei L , et al. Experimental study on the chemico-physical interaction between a two-component cyanoacrylate glue and the material of PICCs. J Vasc Access 2018; 19: 58–62.

Walz JM Ellison RT Mack DA , et al. The bundle “plus”: the effect of a multidisciplinary team approach to eradicate central line-associated bloodstream infections. Anesth Analg 2015; 120: 868–876.

Rossetti F Pittiruti M Lamperti M , et al. The intracavitary ECG method for positioning the tip of central venous access devices in pediatric patients: results of an Italian multicenter study. J Vasc Access 2015; 16: 137–143.

Bugden S Shean K Scott M , et al. Skin glue reduces the failure rate of emergency department–inserted peripheral intravenous catheters: a randomized controlled trial. Ann Emerg Med 2016; 68: 196–201.

Scoppettuolo G Dolcetti L Emoli A , et al. Further benefits of cyanoacrylate glue for central venous catheterisation. Anaesthesia 2015; 70: 758.

Boyce JM Pittet D. Healthcare infection control practices advisory committee, HICPAC/SHEA/APIC/IDSA hand hygiene task force. Guideline for hand hygiene in health-care settings. Recommendations of the healthcare infection control practices advisory committee and the HICPAC/SHEA/APIC/IDSA hand hygiene task force. Society for healthcare epidemiology of America/Association for professionals in infection control/infectious diseases society of america. MMWR Recomm Reports Morb Mortal Wkly Report Recomm Reports 2002; 51(RR-16): 1–45

World Health Organization (WHO). WHO guidelines on hand hygiene in health care. Geneva: Switz WHO, 2009.

(WHO) WHO. Hand Hygiene in outpatient and home-based care and long term care facilities, 2012.

Ellingson K Haas JP Aiello AE , et al. Strategies to prevent healthcare-associated infections through hand hygiene. Infect Control Hosp Epidemiol 2014; 35: 937–960.

Ullman AJ Cooke ML Gillies D , et al. Optimal timing for intravascular administration set replacement. Cochrane Database Syst Rev 2013; 9: CD003588.

Hadaway L. Needleless connectors for IV catheters. Am J Nurs 2012; 112: 32–44.

Velasquez Reyes DC Bloomer M Morphet J. Prevention of central venous line associated bloodstream infections in adult intensive care units: a systematic review. Intensive Crit Care Nurs 2017; 43: 12–22.

Casey AL Karpanen TJ Nightingale P , et al. An in vitro comparison of standard cleaning to a continuous passive disinfection cap for the decontamination of needle-free connectors. Antimicrob Resist Infect Control 2018; 7(1): 50.

Sherertz RJ Karchmer TB Palavecino E , et al. Blood drawn through valved catheter hub connectors carries a significant risk of contamination. Eur J Clin Microbiol Infect Dis 2011; 30: 1571–1577.

Bell T O’Grady NP. Prevention of central line–associated bloodstream infections. Infect Dis Clin North Am 2017; 31: 551–559.

Inchingolo R Pasciuto G Magnini D , et al. Educational interventions alone and combined with port protector reduce the rate of central venous catheter infection and colonization in respiratory semi-intensive care unit. BMC Infect Dis 2019; 19(1): 215.

Marschall J Mermel LA Fakih M , et al. Strategies to prevent central line–associated bloodstream infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 2014; 3: 753–771.

Moureau NL Flynn J. Disinfection of needleless connector hubs: clinical evidence systematic review. Nurs Res Pract 2015; 2015: 796762.

Sandora TJ Graham DA Conway M , et al. Impact of needleless connector change frequency on central line-associated bloodstream infection rate. Am J Infect Control 2014; 42: 485–489.

González López JL Arribi Vilela A Fernández del Palacio E , et al. Indwell times, complications and costs of open vs closed safety peripheral intravenous catheters: a randomized study. J Hosp Infect 2014; 86: 117–126.

Tamura N Abe S Hagimoto K , et al. Unfavorable peripheral intravenous catheter replacements can be reduced using an integrated closed intravenous catheter system. J Vasc Access 2014; 15: 257–263.

Administration UF and D. Safety considerations to mitigate the risks of misconnections with small-bore connectors intended for enteral applications, 2015

Hadaway L. Infusion therapy equipment. In: Alexander M Corrigan A Gorski L Hankins J Perucca R. (eds). Infusion nursing: An evidence based approach. 3rd ed. St Louis, MO: Saunders/Elsevier, 2010.

Ayers P Adams S Boullata J , et al. A.S.P.E.N. parenteral nutrition safety consensus recommendations. J Parenter Enteral Nutr 2014; 38: 296–333.

Alexandrou E Ramjan LM Spencer T , et al. The use of midline catheters in the adult acute care setting—clinical implications and recommendations for practice. J Assoc Vasc Access 2011; 16: 35–41.

Broadhurst D Moureau N Ullman AJ. World congress of vascular access (WoCoVA) skin impairment management advisory panel. management of central venous access device-associated skin impairment: an evidence-based algorithm. J Wound Ostomy Continence Nurs 2017; 44: 211–220.

McNichol L Lund C Rosen T , et al. Medical adhesives and patient safety: state of the science: consensus statements for the assessment, prevention, and treatment of adhesive-related skin injuries. Orthop Nurs 2013; 32: 267–281.

Paglialonga F Consolo S Biasuzzi A , et al. Reduction in catheter-related infections after switching from povidone-iodine to chlorhexidine for the exit-site care of tunneled central venous catheters in children on hemodialysis. Hemodial Int 2014; 18: S13–S18.

Yamamoto N Kimura H Misao H , et al. Efficacy of 1.0% chlorhexidine-gluconate ethanol compared with 10% povidone-iodine for long-term central venous catheter care in hematology departments: a prospective study. Am J Infect Control 2014; 42: 574–576.

Tamma PD Aucott SW Milstone AM. Chlorhexidine use in the neonatal intensive care unit: results from a national survey. Infect Control Hosp Epidemiol 2010; 31: 846–849.

Alam MA Ali NA Sultana N , et al. Newborn umbilical cord and skin care in Sylhet District, Bangladesh: Implications for the promotion of umbilical cord cleansing with topical chlorhexidine. J Perinatol 2008; 28 (Suppl 2): S61–S68.

Baram A Majeed G Abdullah H , et al. Heparin versus saline solution for locking of totally implantable venous access port (TIVAP): cohort study of the first kurdistan series of TIVAP. Adv Lung Cancer 2014; 03(04): 67–74.

Devrim İ Oruç Y Demirağ B , et al. Central line bundle for prevention of central line-associated bloodstream infection for totally implantable venous access devices (ports) in pediatric cancer patients. J Vasc Access 2018; 19: 358–365.

Guiffant G Durussel JJ Flaud P , et al. Flushing ports of totally implantable venous access devices, and impact of the Huber point needle bevel orientation: experimental tests and numerical computation. Med Devices 2012; 5: 31–37.

Goossens GA Jérôme M Janssens C , et al. Comparing normal saline versus diluted heparin to lock non-valved totally implantable venous access devices in cancer patients: a randomised, non-inferiority, open trial. Ann Oncol Off J Eur Soc Med Oncol 2013; 24: 1892–1899.

Rosenbluth G Tsang L Vittinghoff E , et al. Impact of decreased heparin dose for flush-lock of implanted venous access ports in pediatric oncology patients. Pediatr Blood Cancer 2014; 61: 855–858.

Conway MA McCollom C Bannon C. Central venous catheter flushing recommendations. J Pediatr Oncol Nurs 2014; 31: 185–190.

López-Briz E Ruiz Garcia V Cabello JB , et al. Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults. Cochrane Database Syst Rev 2018; 7: CD008462.

Solinas G Platini F Trivellato M , et al. Port in oncology practice: 3-monthly locking with normal saline for catheter maintenance, a preliminary report. J Vasc Access 2017; 18: 325–327.

Ullman AJ Cooke M Rickard CM. Examining the role of securement and dressing products to prevent central venous access device failure: a narrative review. J Assoc Vasc Access 2015; 20: 99–110.

Krenik KM Smith GE Bernatchez SF. Catheter securement systems for peripherally inserted and nontunneled central vascular access devices: clinical evaluation of a novel sutureless device. J Infus Nurs 2016; 39: 210–217.

Cordovani D Cooper RM. A prospective trial on a new sutureless securement device for central venous catheters. Can J Anesth Can d’anesthésie 2013; 60: 504–505.

Pittiruti M Scoppettuolo G Dolcetti L , et al. Clinical experience of a subcutaneously anchored sutureless system for securing central venous catheters. Br J Nurs 2019; 28: S4–14.

Toh LMHW Mavili E Moineddin R , et al. Are cuffed peripherally inserted central catheters superior to uncuffed peripherally inserted central catheters? a retrospective review in a tertiary pediatric center. J Vasc Interv Radiol 2013; 24: 1316–1322.

Egan GM Siskin GP Weinmann R , et al. A prospective postmarket study to evaluate the safety and efficacy of a new peripherally inserted central catheter stabilization system. J Infus Nurs 2013; 36: 181–188.

Macmillan T Pennington M Summers JA , et al. SecurAcath for securing peripherally inserted central catheters: a nice medical technology guidance. Appl Health Econ Health Policy 2018; 16: 779–791.

Luo X Guo Y Yu H , et al. Effectiveness, safety and comfort of StatLock securement for peripherally-inserted central catheters: a systematic review and meta-analysis. Nurs Health Sci 2017; 19: 403–413.

Hatakeyama N Hori T Yamamoto M , et al. An evaluation of peripherally inserted central venous catheters for children with cancer requiring long-term venous access. Int J Hematol 2011; 94: 372–377.

Yamamoto AJ Solomon JA Soulen MC , et al. Sutureless securement device reduces complications of peripherally inserted central venous catheters. J Vasc Interv Radiol 2002; 13: 77–81.

Waterhouse J Bandisode V Brandon D , et al. Evaluation of the use of a stabilization device to improve the quality of care in patients with peripherally inserted central catheters. AACN Adv Crit Care 2014; 25: 213–220.

Dolcino A Salsano A Dato A , et al. Potential role of a subcutaneously anchored securement device in preventing dislodgment of tunneled-cuffed central venous devices in pediatric patients. J Vasc Access 2017;18:540–545.

Patanella I Papa A. SecurAcath VS Statlock per la sicurezza dei PICC in ambito pediatrico. Hematol Rep 2018; 10: s1.

Griswold S Bonaroti A Rieder CJ , et al. Investigation of a safety-engineered device to prevent needlestick injury: why has not StatLock stuck? BMJ Open 2013; 3(4): e002327.

Elen Hughes M . Reducing PICC migrations and improving patient outcomes. Br J Nurs 2014;23(2):S12, S14-8.

Pinelli F Pittiruti M Van Boxtel T , et al. GAVeCeLT-WoCoVA Consensus on subcutaneously anchored securement devices for the securement of venous catheters: Current evidence and recommendations for future research. J Vasc Access 2020; 2020; 1129729820924568

Pittiruti M Bertoglio S Scoppettuolo G , et al. Evidence-based criteria for the choice and the clinical use of the most appropriate lock solutions for central venous catheters (excluding dialysis catheters): a gavecelt consensus. J Vasc Access 2016; 17: 453–464.

Zhong L Wang H-L Xu B , et al. Normal saline versus heparin for patency of central venous catheters in adult patients - a systematic review and meta-analysis. Crit Care 2017; 21(1): 5.

Bertoglio S Rezzo R Merlo FD , et al. Pre-filled normal saline syringes to reduce totally implantable venous access device-associated bloodstream infection: a single institution pilot study. J Hosp Infect 2013; 84: 85–88.

Dolan SA Arias KM Felizardo G , et al. APIC position paper: Safe injection, infusion, and medication vial practices in health care. Am J Infect Control 2016; 44: 750–757.

Goossens GA . Flushing and locking of venous catheters: available evidence and evidence deficit. Nurs Res Pract 2015; 2015: 1–12.

Celetti SJ Vaillancourt R Pascuet E , et al. Taste and/or odour disturbances in pediatric patients undergoing iv flush with normal saline administered by prefilled syringe. Can J Hosp Pharm 2012; 65: 368–372.

Tribler S Brandt CF Petersen AH , et al. Taurolidine-citrate-heparin lock reduces catheter-related bloodstream infections in intestinal failure patients dependent on home parenteral support: a randomized, placebo-controlled trial. Am J Clin Nutr 2017; 106: 839–848.

Handrup MM Møller JK Schrøder H. Central venous catheters and catheter locks in children with cancer: A prospective randomized trial of taurolidine versus heparin. Pediatr Blood Cancer 2013; 60: 1292–1298.

Simon A Ammann RA Wiszniewsky G , et al. Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients. BMC Infect Dis 2008; 8: 8–15.

Gudiol C Nicolae S Royo-Cebrecos C , et al. Administration of taurolidine-citrate lock solution for prevention of central venous catheter infection in adult neutropenic haematological patients: a randomised, double-blinded, placebo-controlled trial (TAURCAT). Trials 2018; 19(1): 264.

Zacharioudakis IM Zervou FN Arvanitis M , et al. Antimicrobial lock solutions as a method to prevent central line–associated bloodstream infections: a meta-analysis of randomized controlled trials. Clin Infect Dis 2014; 59: 1741–1749.

Bradshaw JH Puntis JWL . Taurolidine and catheter-related bloodstream infection: a systematic review of the literature. J Pediatr Gastroenterol Nutr 2008; 47: 179–186.

Bookstaver PB Rokas KEE Norris LB , et al. Stability and compatibility of antimicrobial lock solutions. Am J Heal Pharm 2013; 70: 2185–2198.

Landry DL Braden GL Gobeille SL , et al. Emergence of gentamicin-resistant bacteremia in hemodialysis patients receiving gentamicin lock catheter prophylaxis. Clin J Am Soc Nephrol 2010; 5: 1799–1804.