Hobnail hemangioma is a small benign vascular malformation of the superficial and mid-dermis with variable clinical presentation.
Objectives:
To review the clinical characteristics of hobnail hemangioma in pediatric patients.
Methods:
A retrospective chart review performed of all histopathologically confirmed cases of hobnail hemangioma from May 2000 to December 2014. Data on demographics, clinical characteristics, and results of immunohistochemical staining were collected.
Results:
Four male and 2 female patients identified. Congenital lesions were reported in 3 cases. The most common anatomic location was the extremities. Treatment options included observation and surgical excision.
Conclusions:
Hobnail hemangioma is an uncommon benign vascular malformation. Due to its benign nature, treatment is not required. If treatment is indicated, complete surgical excision appears to be the most effective option.
TrindadeFKutznerHTellecheaO. Hobnail hemangioma reclassified as superficial lymphatic malformation: a study of 52 cases. J Am Acad Dermatol. 2012;66:112-115.
2.
JoyceJCKeithPJSzaboS. Superficial hemosiderotic lymphovascular malformation (hobnail hemangioma): a report of six cases. Pediatr Dermatol. 2014;31(3):281-285.
3.
Al DhaybiRLamCHatamiA. Targetoid hemosiderotic hemangiomas (hobnail hemangiomas) are vascular lymphatic malformations: a study of 12 pediatric cases. J Am Acad Dermatol. 2012;66:116-120.
4.
Santa CruzDJAronbergJ.Targetoid hemosiderotic hemangioma. J Am Acad Dermatol. 1988;19:550-558.
5.
GuillouLCalonjeESpeightP. Hobnail hemangioma: a pseudomalignant vascular lesion with a reappraisal of targetoid hemosiderotic hemangioma. Am J Surg Pathol. 1999;23:97-105.
6.
YoonSYKwonHHJeonHC. Congenital and multiple hobnail hemangiomas. Ann Dermatol. 2011;23:539-543.
7.
IbrahimMShwayderT.Hobnail hemangioma in a nine-year-old boy: a rare case presented with dermoscopy. Dermatol Online J. 2010;16:7.
8.
HejnoldMDyduchGMojsaI. Hobnail hemangioma: a immunohistochemical study and literature review. Pol J Pathol. 2012;63(3):189-192.
9.
MentzelTPartanenTAKutznerH.Hobnail hemangioma (“targetoid hemosiderotic hemangioma”): clinicopathologic and immunohistochemical analysis of 62 cases. J Cutan Pathol. 1999;26:279-286.
10.
ChristensonLVanBeekMDavisD.Targetoid hemosiderotic hemangioma occurring in a father and son. Arch Dermatol. 2000;136:1571-1572.
11.
ChristensonLJStoneMS.Trauma-induced simulator of targetoid hemosiderotic hemangioma. Am J Dermatopathol. 2001;23:221-223.
12.
KimDSRyuDJRohMR. Multiple hobnail hemangiomas. Int J Dermatol. 2014;53(4):e240-e242.
13.
HejnoldMDyduchGMojsaI. Hobnail hemangioma. Pol J Pathol. 2012;63(2):138-141.
14.
HiremathSKCharantimathSByakodiS. Oral hobnail hemangioma: a case report. Arch Iran Med. 2013;16(7):428-430.
15.
RashmiMSAlkaKDSeemaC.Oral hobnail hemangioma: a case report. Quintessence Int. 2008;39(6):507-510.
16.
Vieira CurySEChainHartungHabibeRSiroteauCorrêaPontesF. Oral hobnail hemangioma: case report. Minerva Stomatol. 2009;58(11-12):613-616.
17.
TanCZhuWLaiR.A recurrent case of targetoid hemosiderotic hemangioma. Acta Derm Venereol. 2008;88:181-182.
18.
GendernalikSBGendernalikJD.Recurrent targetoid hemosiderotic hemangioma in a 26-year-old man. J Am Osteopath Assoc. 2011;111(2):117-118.
19.
Ortiz-ReyJAGonzalez-RuizASan MiguelP. Hobnail haemangioma associated with the menstrual cycle. J Eur Acad Dermatol Venereol. 2005;19:367-369.
20.
CarlsonJADaulatSGoodheartHP.Targetoid hemosiderotic hemangioma—a dynamic tumor: report of 3 cases with episodic and cyclic changes and comparison with solitary angiokeratomas. J Am Acad Dermatol. 1999;41:215-224.
21.
MartinRAHowardFMJrSalamoneCR. Spinal cord vascular malformations with symptoms during menstruation. Report of two cases. J Neurosurg. 1977;47:626-629.
22.
MoyRLLuftmanDBNguyenQH. Estrogen receptors and the response to sex hormones in angiolymphoid hyperplasia with eosinophilia. Arch Dermatol. 1992;128:825-828.
23.
MendelsohnME.Genomic and nongenomic effects of estrogen in the vasculature. Am J Cardiol. 2002;90:3F-6F.
24.
XiaoXHongLShengM.Promoting effect of estrogen on the proliferation of hemangioma vascular endothelial cells in vitro. J Pediatr Surg. 1999;34:1603-1605.
25.
SahinMTDemirMAGunduzK. Targetoid haemosiderotic haemangioma: dermoscopic monitoring of three cases and review of the literature. Clin Exp Dermatol. 2005;30(6):672-676.
