Locomotor training using body weight support on a treadmill improves mobility in persons with multiple sclerosis: a pilot study

Freeman JA . Improving mobility and functional independence in persons with MS. J Neurol 2001; 248: 255–59.

Weinshenker BG , Bass B , Rice G , Noseworthy J , Carriere W , Baskerville J . The natural history of MS: a geographically based study. Clinical course and disability. Brain 1989; 112: 133–46.

Kornblith A , LaRocca N , Baum H . Employment in individuals with MS. Int J Rehab Res 1986; 9: 155–65.

Jackson M , Quaal C , Reeves M . Effect of MS on occupational and career patterns. Axone 1991; 13: 16–22.

Ragnarsson K . Health maintenance and reduction of disability through physical exercise. In Apple D ed. Physical fitness: a guide to individuals with spinal cord injury. Department of Veterans Affairs Rehabilitation Research and Development Service, 1996.

Barbeau H , Wainberg M , Finch L . Description and application of a system for locomotor rehabilitation. Med Biol Eng Comput 1987; 25: 341–44.

Harkema S . Neural plasticity after human spinal cord injury: application of locomotor training to the rehabilitation of walking. Neuroscientist 2001; 7: 455–68.

Finch L , Barbeau H , Arsenault B . Influence of body weight support on normal human gait: development of a retraining strategy. Phys Ther 1991; 71: 842–56.

Visinitin M , Barbeau H . The effects of body weight support on the locomotor pattern of spastic paretic patients. Can J Neurol Sci 1989; 16: 315–25.

Wernig A , Muller S . Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries. Paraplegia 1992; 30: 229–38.

Wernig A , Muller S , Nanassy A , Cagol E . Laufband therapy based on ‘rules of spinal locomotion’ is effective in spinal cord injured persons. Eur J Neurosci 1995; 7: 823–29.

Wernig A , Nanassy A , Muller S . Maintenance of locomotor abilities following Laufband therapy in para and tetraplegic persons: follow-up studies. Spinal Cord 1998; 36: 744–48.

Wirz M , Colombo G , Dietz V . Long term effects of locomotor training in spinal humans. J Neurol Neurosurg Psychiatry 2001; 71: 93–96.

Barbeau H , Danakas M , Arsenault B . The effects of locomotor training in spinal cord injured subjects - a preliminary study. Restor Neurol Neurosci 1993; 5: 81–84.

Protas E , Holmes A , Qureshy H , Johnson A , Lee D , Sherwood A . Supported treadmill ambulation training after spinal cord injury: a pilot study. Arch Phys Med Rehabil 2001; 82: 825–31.

Field-Fote E . Combined use of body weight support, functional electrical stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury. Arch Phys Med Rehabil 2001; 82: 818–24.

McDonald WI , Compston A , Edan G , Goodkin D , Hartung HP , Lublin FB . Recommended diagnostic criteria for MS: guidelines from the international panel on the diagnosis of MS. Ann Neurol 2001; 50: 121–27.

Kurtzke JF . Rating neurologic impairment in MS: an expanded disability status scale. Neurology 1983; 33: 1444–52.

Berg KO , Maki JI , Williams PJ , Holliday PJ , Wood-Dauphinee SL . Clinical and laboratory measures of postural balance in an elderly population. Arch Phys Med Rehabil 1992; 73: 1073–80.

Bohannon RW , Smith MB . Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 1987; 67: 206–207.

Hobart J , Lamping D , Fitzpatrick R , Riazi A , Thompson A . The Multiple Sclerosis Impact Scale (MSIS): a new patient based outcome measure. Brain 2001; 124: 962–73.

Stevenson TJ . Detecting change in patients with stroke using the Berg Balance Scale. Aust J Physiother 2001; 47: 29–38.

Van den Berg M , Dawes H , Wade DT , Newman M , Burridge J , Izadi H . Treadmill training for individuals with MS: a pilot randomized trial. J Neurol Neurosurg Psychiatry 2006; 77: 531–33.

Freeman JA , Langdon D , Hobart J , Thompson A . Inpatient rehabilitation in MS: do the benefits carry over into the community? Neurology 1999; 52: 50–56.

Solari A , Fillipini G , Gasco P , Colla L , Salmaggi A , LaMantia L . Physical rehabilitation has a positive effect on disability in MS patients. Neurology 1999; 52: 57–62.

Patti F , Cianco M , Cacopardo M , Reggio E , Fiorilla T , Palermo F . effects of a short outpatient rehabilitation treatment on disability of MS patients. J Neurol 2003; 250: 861-66.

White L , Dressendorfer R . Exercise and MS. Sports Med 2004; 34: 1077–100.

Ponichtera J , Matthews T , Barett P , Glaser RM . Changes in aerobic fitness of patients with MS during a 6 month training program. Ann Neurol 1996; 39: 432–41.

Oken B , Kishiyama S , Zaidel D , Bourdette D , Carlsen J , Haas M . Randomized controlled trial of yoga and MS after a 6 month training program. Sports Med Train Rehab 1997; 7: 265–72.

White LJ , McCoy SC , Castellano V , Gutierrez G , Stevens JE , Walter GA . Resistance training improves strength and functional capacity in persons with MS. Mult Scler 2004; 10: 668–74.

Rodgers M , Mulcare J , King D , Mathews T , Gupta SC , Glaser R . Gait characteristics of individuals with MS before and after a 6 month aerobic training program. J Rehab Res Dev 1999; 36: 183–88.

Romberg A , Virtanen J , Ruutianen S , Aunola S , Karppi S-L , Vaara M . Effects of a 6 month exercise program on patients with MS: a randomized study. Neurology 2004; 63: 2034–38.

Perry J , Garrett M , Gromley JK , Mulroy SJ . Classification of walking handicap in the stroke population. Stroke 1995; 26: 982–89.

Mevellee E , Lamotte D , Cantaloube S , Amarenco G , Thounie P . Relationship between gait speed and strength parameters in MS. Ann Readapt Med Phys 2003; 46: 85–90.

Tillakarane N , de Leon R , Hoang T , Roy R , Edgerton VR , Tobin A . Use dependant modulation of inhibitory capacity in the feline spinal cord. J Neurosci 2002; 22: 3130–43.

Robinson G , Goldberger M . The development and recovery of motor function in spinal cats. Part II: pharmacologic enhancement of recovery. Exp Brain Res 1986; 62: 387–400.

Young R . Spasticity. Ann Rev Neurol 1994; 44: S12-20.

Dietz V , Colombo G , Jensen L , Baumgartner L . Locomotor capacity of spinal cord in paraplegic patients. Ann Neurol 1995; 37: 574–82.

Harkema S . Unpublished observations.

Petajan J , Gappmaier E , White A , Spencer MK , Mino L , Hicks R . Impact of aerobic training on fitness and quality of life in MS. Ann Neurol 1996; 39: 432–41.

Mostert S , Kesselreing J . Effects of a short term exercise training program on aerobic fitness, fatigue health perception and activity level of subjects with MS. Mult Scler 2002; 8: 161–68.

Pittock S , Mayr W , McCleland RL , Jorgensen N , Weigand S , Noseworthy J . Quality of life is favorable for most patients with MS: a population based cohort study. Arch Neurol 2004; 61: 679–86.

Isaksson A-K , Ahlstrom G , Gunnarsson L-G . Quality of life and impairment in MS. J Neurol Neurosurg Psychiatry 2005; 76: 64–69.

Forssberg H . On integrative motor functions in the cat spinal cord. Acta Physiol Scand 1979; 474: 1–56.

Grillner S , Zangger P . How detailed is the central pattern generation for locomotion? Brain Res 1975; 88: 367–71.

McCrea D . Spinal circuitry of sensorimotor control of locomotion. J Physiol 2001; 53: 41–50.

Edgerton V , Grillner S , Sjostrom A , Zangger P . Central generation of locomotion in vertebrates. In: Herman S , Grillner S , Stein P , Stuart DG eds. Neural control of locomotion. Plenum Press, 1976: 439–64.

Grillner S , Dubuc R . Control of locomotion in vertebrates: spinal and supraspinal mechanisms. In: Waxman SG ed. Advances in Neurology. Volume 47: Functional recovery in neurologic disease. Raven Press, 1988: 425–53.

Bussel B , Roby-Brami A , Neris OR , Yakovleff A . Evidence for a spinal stepping generator in man. Electrophysiological study. Acta Neurobiol Exp 1996; 56: 465–68.

Dimitrijevic M , Gerasimenko Y , Pinter M . Evidence for a spinal central pattern generator in humans. Ann NY Acad Sci 1998; 860: 360–76.

Beres JA , Joaquin R , Lukacs R , van den Brand R , Schouten W , Gordon K . Neural plasticity of the human spinal cord occurs with locomotor training. Soc Neurosci Abstracts 2001; 27: 935.14.

Dobkin B , Harkema S , Requejo P , Edgerton VR . Modulation of locomotor like EMG activity in subjects with complete and incomplete spinal cord injury. J Neurol Rehab 1995; 9: 183–90.

Harkema S , Dobkin B , Edgerton V . Pattern generations in locomotion: implications for recovery of walking after spinal cord injury. Top Spinal Cord Inj Rehabil 2000; 6: 82–96.

Harkema S , Hurlye S , Patel U , Requejo P , Dobkin B , Edgerton VR . Human lumbosacral spinal cord interprets loading during stepping. J Neurophysiol 1997; 77: 797–811.

Nielsen J . How we walk: central control of muscle activity during human walking. Neuroscientist 2003; 9: 195–204.

Mikulis D , Jurkiewicz M , Mcilroy W , Staines W , Rickards L , Kalsi-Ryan S . Adaptation in the motor cortex following cervical spinal cord injury. Neurology 2002; 58: 794–801.

Corbetta M , Burton H , Sinclair R , Conturo T , Akbudak E , McDonald J . Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery. Proc Natl Acad Sci 2002; 99: 17066–71.

Filippi M , Rocca M . Disturbed function and plasticity in MS as gleaned from fMRI. Curr Opin Neurol 2003; 16: 275–82.

Saini S , DeStefano N , Smith S , Guidi L , Amato M , Federico A , Matthews P . Altered cerebellar functional connectivity mediates potential adaptive plasticity in patients with MS. J Neurol Neurosurg Psychiatry 2004; 75: 840–46.

Rocca M , Fulini A , Colombo B , Scotti G , Comi G , Filippi M . Adaptive functional changes in the cerebral cortex of patients with non-disabling MS correlate with the extent of brain structural damage. Ann Neurol 2002; 51: 330–39.

Fukuyama H , Ouchi Y , Matsuzaki S , Nagahama Y , Yamauchi H , Ogawa . Brain functional activity during gait in normal subjects: a SPECT study. Neurosci Lett 1997; 228: 183–86.

Dobkin B , Firestine A , West M , Saremi K , Woods R . Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation. Neuroimage 2004; 23: 370–81.

Winchester P , McColl R , Querry R , Foreman N , Mosby J , Tansey K . Changes in supraspinal activation patterns following robotic locomotor therapy in motor incomplete SCI. Neurorehabil Neural Repair 2005; 19: 313–24.