Cognitive impairment at the onset of multiple sclerosis: relationship to lesion location

Abstract

The impact of lesion location on cognitive functioning was assessed in a group of 97 patients with a clinically isolated syndrome. Using the Brief Repeatable Battery, we evidenced that 24% of patients showed at least one abnormal test, 20% at least two and 15% at least three. Verbal learning performances were inversely associated with presence of lesions in Broca’s area, in the right frontal lobe and in the splenium while spatial learning performances were inversely correlated to the presence of lesions in the deep white matter. No associations were evidenced between lesion location and performance of tasks exploring attention and executive functions.

Keywords

cognition MRI T2 lesions

Get full access to this article

View all access options for this article.

References

Achiron

Barak

. Cognitive impairment in probable multiple sclerosis. J Neurol Neurosurg Psychiatry 2003; 74: 443–446.

Zipoli

Goretti

Hakiki

. Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes. Mult Scler 16: 62–67.

Glanz

Holland

Gauthier

. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler 2007; 13: 1004–1010.

Potagas

Giogkaraki

Koutsis

. Cognitive impairment in different MS subtypes and clinically isolated syndromes. J Neurol Sci 2008; 267: 100–106.

Feuillet

Reuter

Audoin

. Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler 2007; 13: 124–127.

Feinstein

Kartsounis

Miller

Youl

Ron

. Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow up study. J Neurol Neurosurg Psychiatry 1992; 55: 869–876.

Boringa

Lazeron

Reuling

. The brief repeatable battery of neuropsychological tests: normative values allow application in multiple sclerosis clinical practice. Mult Scler 2001; 7: 263–267.

Sepulcre

Masdeu

Pastor

. Brain pathways of verbal working memory: a lesion–function correlation study. Neuroimage 2009; 47: 773–778.

Baddeley

. Working memory: looking back and looking forward. Nat Rev Neurosci 2003; 4: 829–839.

10.

Benedict

Ramasamy

Munschauer

Weinstock-Guttman

Zivadinov

. Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy. J Neurol Neurosurg Psychiatry 2009; 80: 201–206.

11.

Audoin

Au Duong

Ranjeva

. Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis. Hum Brain Mapp 2005; 24: 216–228.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.43 MB