Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder

Abstract

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.

Keywords

Myelin water imaging multiple sclerosis neuromyelitis optica spectrum disorder demyelination

Get full access to this article

View all access options for this article.

References

Lucchinetti

Guo

Popescu

. The pathology of an autoimmune astrocytopathy: Lessons learned from neuromyelitis optica. Brain Pathol 2014; 24: 83–97.

Kim

Paul

Lana-Peixoto

. MRI characteristics of neuromyelitis optica spectrum disorder: An international update. Neurology 2015; 84: 1165–1173.

Matthews

Marasco

Jenkinson

. Distinction of seropositive NMO spectrum disorder and MS brain lesion distribution. Neurology 2013; 80: 1330–1337.

Kremer

Renard

Achard

. Use of advanced magnetic resonance imaging techniques in neuromyelitis optica spectrum disorder. JAMA Neurol 2015; 72: 815–822.

MacKay

Whittall

Adler

. In vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med 1994; 31: 673–677.

Laule

Leung

. Myelin water imaging in multiple sclerosis: Quantitative correlations with histopathology. Mult Scler 2006; 12: 747–753.

Laule

Vavasour

Moore

. Water content and myelin water fraction in multiple sclerosis. A T2 relaxation study. J Neurol 2004; 251: 284–293.

Vavasour

Laule

. Multi-parametric MR assessment of T(1) black holes in multiple sclerosis: Evidence that myelin loss is not greater in hypointense versus isointense T(1) lesions. J Neurol 2007; 254: 1653–1659.

Van Walderveen

Kamphorst

Scheltens

. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 1998; 50: 1282–1288.

10.

Polman

Reingold

Banwell

. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292–302.

11.

Prasloski

Rauscher

MacKay

. Rapid whole cerebrum myelin water imaging using a 3D GRASE sequence. NeuroImage 2012; 63: 533–539.

12.

Lucchinetti

Bruck

Parisi

. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol 2000; 47: 707–717.

13.

Misu

Hoftberger

Fujihara

. Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica. Acta Neuropathol 2013; 125: 815–827.

14.

Wingerchuk

Lennon

Lucchinetti

. The spectrum of neuromyelitis optica. Lancet Neurol 2007; 6: 805–815.

15.

Manogaran

Vavasour

Borich

. Corticospinal tract integrity measured using transcranial magnetic stimulation and magnetic resonance imaging in neuromyelitis optica and multiple sclerosis. Mult Scler 2016; 22: 43–50.

16.

Kim

Huh

Hyun

. A longitudinal brain magnetic resonance imaging study of neuromyelitis optica spectrum disorder. PLoS ONE 2014; 9: e108320.

17.

Pittock

Weinshenker

Lucchinetti

. Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression. Arch Neurol 2006; 63: 964–968.

18.

Matsushita

Isobe

Matsuoka

. Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. Mult Scler 2009; 15: 1113–1117.

19.

Bruck

Bitsch

Kolenda

. Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997; 42: 783–793.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.02 MB