Whether disease course in Hispanic Americans (HA) with multiple sclerosis (MS) is different from Caucasian Americans (CA) or African Americans (AA) is unknown. We compared MS severity in the three main ethnic populations in our tertiary MS clinics using disease duration–adjusted rank score of disability: Patient-Derived Multiple Sclerosis Severity Score (P-MSSS). The age- and gender-adjusted P-MSSS was significantly higher in HA (3.9 ± 2.6) and AA (4.5 ± 3.0) compared to CA (3.4 ± 2.6; p < 0.0001 for both). Adjusting for insurance did not change these results. These findings suggest that HA, as AA, have more rapid disability accumulation than CA.
KaufmanMDJohnsonSKMoyerDet al. Multiple sclerosis: Severity and progression rate in African Americans compared with whites. Am J Phys Med Rehabil2003; 82(8): 582–590.
2.
MarrieRACutterGTyryTet al. Does multiple sclerosis-associated disability differ between races?Neurology2006; 66(8): 1235–1240.
3.
NaismithRTTrinkausKCrossAH. Phenotype and prognosis in African-Americans with multiple sclerosis: A retrospective chart review. Mult Scler2006; 12(6): 775–781.
4.
Weinstock-GuttmanBJacobsLDBrownscheidleCMet al. Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium. Mult Scler2003; 9(3): 293–298.
5.
KisterIChamotEBaconJHet al. Rapid disease course in African Americans with multiple sclerosis. Neurology2010; 75(3): 217–223.
6.
CreeBAKhanOBourdetteDet al. Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. Neurology2004; 63(11): 2039–2045.
7.
AmezcuaLLundBTWeinerLPet al. Multiple sclerosis in Hispanics: A study of clinical disease expression. Mult Scler2011; 17(8): 1010–1016.
8.
BuchananRJZunigaMACarrillo-ZunigaGet al. Comparisons of Latinos, African Americans, and Caucasians with multiple sclerosis. Ethn Dis2010; 20(4): 451–457.
9.
RoxburghRHSeamanSRMastermanTet al. Multiple Sclerosis Severity Score: Using disability and disease duration to rate disease severity. Neurology2005; 64(7): 1144–1151.
10.
RojasJIPatruccoLTrojanoMet al. Multiple sclerosis in Latin America: A different disease course severity? A collaborative study from the MSBase Registry. Mult. Scler. J. Exp. Transl. Clin. Epub ahead of print 17August2015. DOI: 10.1177/2055217315600193.
11.
KisterIChamotESalterARet al. Disability in multiple sclerosis: A reference for patients and clinicians. Neurology2013; 80(11): 1018–1024.
12.
LearmonthYCMotlRWSandroffBMet al. Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis. BMC Neurol2013; 13: 37.
13.
AmezcuaLContiDVLiuLet al. Place of birth, age of immigration, and disability in Hispanics with multiple sclerosis. Mult Scler Relat Disord2015; 4(1): 25–30.
