Furchgott RF, Zawadzki JV.The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature1980; 288: 373-376.
2.
Ignarro LJ, Byrns RE, Buga GM, Wood KS.Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical. Circ Res1987; 61: 866-879.
3.
Furchgott RF.Studies on relaxation of rabbit aorta by sodium nitrite: the basis for the proposal that the acid-activatable inhibitory factor from retractor penis is inorganic nitrite and the endothelium-derived relaxing factor is nitric oxide. In: Vanhoutte P (ed). Mechanisms of Vasodilation. New York: Raven Press, 1988: 401-404.
4.
Palmer RMJ, Ferridge AG, Moncada S.Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature1987; 327: 524-526.
5.
Murad F.The 1996 Albert Lasker Medical Research Awards. Signal transduction using nitric oxide and cyclic guanosine monophosphate. JAMA1996; 276: 1189-1192.
Cooke JP, Dzau VJ.Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med1997; 48: 489-509.
8.
Albina JE, Reichner JS.Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis. Cancer Metastasis Rev1998; 17: 39-53.
9.
Lancaster JR Jr, Hibbs JB Jr.EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. Proc Natl Acad Sci U S A1990; 87: 1223-1227.
10.
Nelson RJ, Demas GE, Huang PLet al.Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature1995; 378: 383-386.
11.
Cooke JP, Stamler J, Andon N, Davies PF, McKinley G, Loscalzo J.Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. Am J Physiol1990; 259 (3 Pt 2): H804-H12.
12.
Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA.Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation1994; 89: 2035-2040.
13.
Garg UC, Hassid A.Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest1989; 83: 1774-1777.
14.
von der Leyen HE, Gibbons GH, Morishita Ret al.Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A1995; 92: 1137-1141.
15.
Schwarzacher SP, Lim TT, Wang BYet al.Local intramural delivery of l-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Circulation1997; 95: 1863-1869.
16.
Lablanche JM, Grollier G, Lusson JRet al.Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem. Circulation1997; 95: 83-89.
17.
Babaei S, Teichert-Kuliszewska K, Monge JC, Mohamed F, Bendeck MP, Stewart DJ.Role of nitric oxide in the angiogenic response in vitro to basic fibroblast growth factor. Circ Res1998; 82: 1007-1015.
18.
Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC.Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest1997; 100: 3131-3139.
19.
Tsao PS, Lewis NP, Alpert S, Cooke JP.Exposure to shear stress alters endothelial adhesiveness: role of nitric oxide. Circulation1995; 92: 3513-3519.
Tsao PS, Wang BY, Buitrago Ret al.Nitric oxide regulates monocyte chemotactic protein-1. Circulation1997; 96: 934-940.
22.
Stamler JS, Mendelsohn ME, Amarante Pet al.N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res1989; 65: 789-795.
23.
Creager MA, Cooke JP, Mendelsohn MEet al.Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest1990; 86: 228-234.
24.
Zeiher AM, Drexler H, Saurbier B, Just H.Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest1993; 92: 652-662.
25.
Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE.Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. JAm Coll Cardiol1994; 24: 1468-1474.
26.
Cayatte AJ, Palacino JJ, Horten K, Cohen RA.Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb1994; 14: 753-759.
27.
Vallance P, Leone A, Calver A, Collier J, Moncada S.Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet1992; 339: 572-575.
28.
Matsuoka H, Itoh S, Kimoto Met al.Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hyper-tension. Hypertension1997; 29: 242-247.
29.
Circulation1998; 98: I733-I733.
30.
Boger RH, Bode-Boger SM, Szuba Aet al.ADMA. A novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation1998; 98: 1842-1847.
31.
Miyazaki H, Matsuoka H, Cooke JPet al.Endogenous nitric oxide synthase inhibitor, a novel marker of atherosclerosis circulation. Circulation1999; 99: 1141-1146.
32.
Faraci FM, Brian JE, Heistad DD.Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol1995; 269: H1522-H27.
33.
Cooke JP, Singer AH, Tsao Pet al.Anti-atherogenic effects of l-arginine in the hypercholesterolemic rabbit. J Clin Invest1992; 90: 1168-1172.
34.
Aji W, Ravalli S, Szabolcs Met all-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice. Circulation1997; 95: 430-437.
35.
Candipan RC, Wang B, Buitrago Ret al.Regression or progression: dependency upon vascular nitric oxide. Arterioscler Thromb Vasc Biol1996; 16: 44-50.
36.
Boger RH, Bode-Boger SM, Brandes RPet al.Dietary l-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin. Circulation1997; 96: 1282-1290.
Drexler H, Zeiher AM, Meinzer K, Just H.Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by l-arginine. Lancet1991; 338: 1546-1550.
39.
Lerman A, Burnett JC Jr, Higano ST, McKinley LJ, Holmes DR Jr.Long-term l-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation1998; 97: 2123-2128.
40.
Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K.Effect of supplemental oral l-arginine on exercise capacity in patients with stable angina pectoris. Am J Cardiol1997; 80: 331-333.
41.
Boger RH, Bode-Boger SM, Thiele W, Creutzig A, Alexander K, Frolich JC.Restoring vascular nitric oxide formation by l-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol1998; 32: 1336-1344.
42.
Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF Jr, Vita JA.Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation1996; 93: 1107-1113.
43.
Gerhard M, Walsh BW, Tawakol Aet al.Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in post-menopausal women. Circulation1998; 98: 1158-1163.
44.
Stroes E, Kastelein J, Cosentino Fet al.Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest1997; 99: 41-46.
45.
Treasure CB, Klein JL, Weintraub WSet al.Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med1995; 332: 481-487.