The continuing explosion of scientific interest in the hippocampus began in the 1950s, initiated in large part by the recognition of the importance of the observations of hippocampectomized monkeys made by Klüver and Bucy and the remarkable memory loss of patient H. M. following temporal lobe surgery. Subsequent to these studies, research and theories about the hippocampus grew exponentially in number and diversity. As yet, no theory of hippocampal function explains all of the phenomena discovered in the clinic or laboratory. In this article, experimental results that have been forgotten or ignored in most theories are presented. Adequate theories of hippocampal function must account for known, reliable postsurgical behavioral observations and consider the conditions under which anomalies are noted. Comprehensive theories will require new approaches in which the interactions of the hippocampus with the central nervous system are understood.
Abrahams, S.
, Pickering, A., Polkey, C. E., & Morris, R. G. (1997). Spatial memory deficits in patients with unilateral damage to the right hippocampal formation. Neuropsychologia, 35, 11-24.
2.
Aggleton, J. P.
, & Brown, M. W. (1999). Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behavioral and Brain Sciences, 22, 425-489.
3.
Allen, W. F.
(1940). Effect of ablating the frontal lobe, hippocampi, and occipitoparieto-temporal (excepting pyriform areas) lobes on positive and negative conditioned reflexes. American Journal of Physiology, 128, 754-771.
4.
Allen, W. F.
(1941). Effect of ablating the pyriform-amygdaloid areas and hippocampi on positive and negative olfactory conditioned reflexes and on conditioned olfactory differentiation. American Journal of Physiology, 132, 81-92.
5.
Alvarez-Buylla, A.
, Garcia-Verdugo, J. M., & Tramontin, A. D. (2001). A unified hypothesis on the lineage of neural stem cells. Nature Reviews: Neuroscience, 2, 287-293.
6.
Alyan, S. H.
, Jander, R., & Best, P. J. (2000). Hippocampectomized rats can use a constellation of landmarks to recognize a place. Brain Research, 876, 225-237.
7.
Bliss, T.V.P.
, & Lømo, T. (1973). Long-lasting potentiation of synaptic transmission on the dentate area of the anesthetized rabbit following stimulation of the perforant path. Journal of Physiology, 232, 331-356.
8.
Bohbot, V. D.
, Kalina, M., Stepankova, K., Spackova, N., Petrides, M., & Nadel, L. (1998). Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex. Neuropsychologia, 36, 1217-1238.
9.
Boitano, J. J.
, Dokla, C.P.J., Mulinski, P., Misikonis, S., & Kaluzynski, T. (1980). Effects of hippocampectomy in an incremental-step DRL paradigm. Physiology and Behavior, 25, 273-278.
10.
Broca, P.
(1878). Anatome comparee des circonvolutions cerebrales. Le grad lobe limbique et la scissure limbique dans la serie des mammifers. Reviews in Anthropology, 1, 385-498.
11.
Brown, R. W.
, Gonzalez, C. L., Whishaw, I. Q., & Kolb, B. (2001). Nicotine improvement of Morris water task performance after fimbria-fornix lesion is blocked by mecamylamine. Behavior Brain Research, 119, 185-192.
12.
Bunsey, M.
, & Eichenbaum, H. (1996). Conservation of hippocampal memory formation in rats and humans. Nature, 379, 255-257.
13.
Carey, R. J.
(1969). Motivational and reinforcement scheduling factors in the effect of hippocampal injury on operant behavior. Physiology and Behavior, 4, 959-961.
14.
Chen, Z.
, Sugimoto, Y., & Kamei, C. (1997). Effects of histamine and its related compounds on impairment of passive avoidance response following hippocampal lesions in rats. Journal of Brain Science, 23, 225-240.
15.
Chen, Z.
, Zhao, Q., Sugimoto, Y., Fujii, Y., & Kamei, C. (1999). Effects of histamine on MK-801 induced memory deficits in radial maze performance in rats. Brain Research, 839, 186-189.
16.
Clark, C.V.H.
, & Isaacson, R. L. (1965). Effect of bilateral hippocampal ablation or DRL performance. Journal of Comparative and Physiological Psychology, 59, 137-140.
17.
Conant, J. B.
(1951). Science and common sense. New Haven: Yale University Press.
18.
Corkin, S.
, Amaral, D. G., Gonzales, G., Johnson, K. A., & Hyman, D. T. (1997). H. M.’s medial temporal lobe lesion: Findings from magnetic resonance imaging. Journal of Neuroscience, 17, 3964-3979.
19.
Decker, M. W.
, Majchrzak, M. J., & Anderson, D. J. (1992). Effects of nicotine on spatial memory deficits in rats with septal lesions. Brain Research, 572, 281-285.
20.
DeFries, J. C.
, & Hegmann, J. P. (1970). Genetic analysis of open-field behavior. New York: Appleton-Century-Crofts.
21.
DeFries, J. C.
, Hegmann, J. P., & Weir, M. W. (1966). Open-field behavior in mice: Evidence for a major gene effect mediated by the limbic system. Science, 154, 1577-1579.
22.
Delay, J.
, & Brion, S. (1969). Le syndrome de Korsakoff [The Korsakoff syndrome]. Paris: Masson.
23.
Dember, W. N.
(1958). Stimulus alternation on peripherally blinded rats. Canadian Journal of Psychology, 12, 219-221.
24.
Dember, W. N.
, & Roberts, W. W. (1958). Alternation behavior in peripherally-blinded rats. Perception and Motor Skills, 8, 91-94.
25.
Douglas, R. J.
(1966a). Cues for spontaneous alternation. Journal of Comparative and Physiological Psychology, 62, 171-183.
26.
Douglas, R. J.
(1966b). Spontaneous alternation and middle ear disease. Psychonomic Science, 4, 243-244.
27.
Douglas, R. J.
, & Isaacson, R. L. (1964). Hippocampal lesions and activity. Psychonomic Science, 1, 187-188.
28.
Einstein, A.
, & Freud, S. (1991). Why war?Redding, CA: CAT Publishing.
29.
Fidler, P. S.
, Schuette, R. A., Asher, R. A., Dobbertin, S. R., Thornton, Y. E., Calle-Patino, J. M., Muir, J. M., Levine, H. M., Geller, J. H., Rogers, A., Faissner, A., & Fawcett, J. W. (1999). Comparing astrocyte cell lines that are inhibitory or permissive for axon growth: The major axon-inhibitory proteoglycan is NG2. Journal of Neuroscience, 19, 8778-8788.
30.
Gaffan, D.
(1992). The role of the hippocampus-fornix-mammillary system in episodic memory. In L. R. Squire & N. Butters (Eds.), Neuropsychology of memory. New York: Guilford.
31.
Gallistel, R. C.
(1995). Is LTP a plausible basis for memory? In J. L. McGaugh, N. M. Weinberger, & G. Lynch (Eds.), Brain and memory: Modulation and mediation of neuroplasticity (pp. 328-337). New York: Oxford University Press.
32.
Gisquet-Verrier, P.
, Dutrieux, G., Richer, P., & Doyere, V. (1999). Effects of lesions to the hippocampus on contextual fear: Evidence for a disruption of freezing and avoidance behavior but not context conditioning. Behavioral Neuroscience, 113, 507-522.
33.
Glickman, S. E.
(1961). Perseverative neural processes and consolidation of the neural trace. Psychological Bulletin, 58, 218-233.
34.
Gloor, P.
(1986). Role of the human limbic system in perception, memory, and affect: Lessons from temporal lobe epilepsy. In B. K. Doane (Ed.), The limbic system: Functional organization and clinical disorders (pp. 159-169). New York: Raven Press.
35.
Goerner, S.
(1995). Chaos, evolution, and deep ecology. In R. Robertson & A. Combs (Eds.), Chaos theory in psychology and the life sciences. Mahwah, NJ: Lawrence Erlbaum.
36.
Gonzalez, C. L.
, Kolb, B., & Whishaw, I. Q. (2000). A cautionary note regarding drug and brain lesion studies that use swimming pool tasks: Partial reinforcement impairs acquisition of place learning in swimming pool but not dry land. Behavior Brain Research, 112, 43-52.
37.
Grastyan, E.
, & Buzsaki, G. (1979). The orienting-exploratory response hypothesis of discriminative conditioning. Acta Neurobiologiae Experimentalis (Warsaw), 39, 491-501.
38.
Grastyan, E.
, Lissak, K., Madarasz, I., & Donhoffer, H. (1959). Hippocampal electrical activity during the development of conditioned reflexes. EEG Clinical Neurophysiology, 11, 409-430.
39.
Hebb, D. O.
(1949). The organization of behavior. New York: John Wiley.
40.
Hebb, D. O.
(1961). Brain mechanisms and learning. In J. F. Delafresnaye (Ed.), Distinctive features of learning in higher animals(pp. 37-51). London: Oxford University Press.
41.
Hermanns, S.
, & Muller, H. W. (2001). Preservation and detection of lesion-induced collagenous scar in the CNS depend on the method of tissue processing. European Journal of Pharmacology: Brain Research Protocols, 7, 162-167.
42.
Isaacson, R. L.
(2000). Non-linear effects in the retention of an avoidance task induced by anabolic steroids. European Journal of Pharmacology, 405, 177-186.
43.
Isaacson, R. L.
, Douglas, R. J., & Moore, R. Y. (1961). The effect of radical hippocampal ablation on acquisition of avoidance response. Journal of Comparative and Physiological Psychology, 54, 625-628.
44.
Isaacson, R. L.
, & McLearn, G. E. (1978). Influence of hippocampal damage on locomotor behavior of mice selectively bred for high or low activity in the open field. Brain Research, 150, 559-567.
45.
Isaacson, R. L.
, & Spear, N. E. (Eds.). (1982). The expression of knowledge. New York: Plenum.
46.
Isaacson, R. L.
, & Wickelgren, W. O. (1962). Hippocampal ablation and passive avoidance. Science, 138, 1104-1106.
47.
Jackson, W. J.
, & Strong, P. N. (1969). Differential effects of hippocampal lesions upon sequential tasks and maze learning by rats. Journal of Comparative and Physiological Psychology, 68, 442-450.
48.
Jarrard, L. E.
, & Isaacson, R. L. (1965). Hippocampal ablation in rats: Effects of intertrial interval. Nature, 207, 109-110.
49.
Jarrard, L. E.
, Isaacson, R. L., & Wickelgren, W. O. (1964). Effects of hippocampal ablation and intertrial interval on runway acquisition and extinction. Journal of Comparative and Physiological Psychology, pp. 442-444.
50.
Johnsrude, I. S.
, Owen, A. M., Crane, J., Milner, B., & Evans, A. C. (1999). A cognitive activation study of memory for spatial relationships. Neuropsychologia, 37, 829-841.
51.
Kaada, B. R.
, Jansen. J. Jr., & Andersen, P. (1953). Stimulation of the hippocampus and medial cortical areas in unanesthetized cats. Neurology, 844-856.
52.
Kamei, C.
, Chen, Z., Nakamura, S., & Sugimoto, Y. (1997). Effects of intracerebroventricular injection of histamine on memory deficits induced by hippocampal lesions in rats. Methods and Findings in Experimental and Clinical Pharmacology, 19, 253-259.
53.
Kamin, L. J.
(1969). Predictability, surprise, attention, and conditioning. In B. A. Campbell & R. M. Church (Eds.), Punishment and aversive behavior (pp. 279-296). New York: Appleton-Century-Crofts.
54.
Kesner, R. M.
, & Rolls, E. T. (2001). Role of long-term synaptic modification in short-term memory. Hippocampus, 11, 1-21.
55.
Kimble, D. P. (1961). The effect of bilateral hippocampal damage on cognitive and emotional behavior in the rat. Unpublished doctoral dissertation, University of Michigan.
56.
Kimble, D. P.
(1963). The effects of bilateral hippocampal lesions in rats. Journal of Comparative and Physiological Psychology, 56, 273-283.
57.
Klüver, H.
(1965). Neurobiology of normal and abnormal perception. In P. C. Hoch & J. Zubin (Eds.), Psychopathology of perception. New York: Grune and Straton.
58.
Klüver, H.
, & Bucy, P. C. (1939). Preliminary analysis of functions of the temporal lobe in monkeys. Archives of Neurology and Psychiatry, 42, 979-1000.
59.
Kowalska, D. M.
, Kusmierek, P., Kosmal, A., & Mishkin, M. (2001). Neither perirhinal/entorhinal nor hippocampal lesions impair short-term auditory recognition memory. Neuroscience, 104, 965-978.
60.
Lashley, K. S.
(1918). A simple maze: With data on the relation of practice to the rate of learning. Psychobiology, 1, 353-367.
61.
Lathe, R.
(2001). Hormones and the hippocampus. Journal of Endocrinology, 169, 205-231.
62.
Leonard, J. A.
, & Newman, R. C. (1967). Spatial orientation in the blind. Nature, 215, 1413-1414.
63.
Levin, E. D.
, Christopher, N. C., Briggs, S. J., & Rose, J. E. (1993). Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basocortical projections. Cognitive Brain Research, 1, 137-144.
64.
Lewis, D. J.
(1969). Sources of experimental amnesia. Psychological Reviews, 76, 461-472.
65.
Lewis, D. J.
, Miller, R. R., & Misanin, J. R. (1968). Control of retrograde amnesia. Journal of Comparative and Physiological Psychology, 66, 48-52.
66.
Lewis, D. J.
, Miller, R. R., & Misanin, J. R. (1969). Selective amnesia in rats produced by electroconvulsive shock. Journal of Comparative and Physiological Psychology, 69, 136-140.
67.
Lindner, M. D.
, Plone, M. A., Schallert, T., & Emerich, D. F. (1997). Blind rats are not profoundly impaired in the reference memory Morris water maze and cannot be clearly discriminated from rats with cognitive deficits in cured platform test. Cognitive Brain Research, 5, 329-333.
68.
MacLean, P. D.
(1949). Psychosomatic disease and the “visceral brain”: Recent developments on Papez theory of emotion. Psychosomatic Medicine, 11, 338-353.
69.
MacLean, P. D.
(1978). A mind of three minds: Educating the triune brain. In 77th yearbook of the National Society for the Study of Education(pp. 308-342). Chicago: University of Chicago Press.
70.
MacLean, P. D.
(1990). The triune brain in evolution. New York: Plenum.
71.
Malkova, L.
, Bachevalier, J., Mishkin, M., & Saunders, R. C. (2001). Neurotoxic lesions of perirhinal cortex impair visual recognition memory in rhesus monkeys. Neuroreport, 12, 1913-1917.
72.
Matzel, L. D.
, & Shors, T. J. (2001). Long-term potentiation and associative learning. Can the mechanism subserve the process? In C. Holscher (Ed.), Neuronal mechanisms of memory formation: Concepts of long-term potentiation and beyond (pp. 294-324). Cambridge, UK: Cambridge University Press.
73.
McEachern, J. C.
, & Shaw, C. A. (1996). An alternative to the LTP orthodoxy: A plasticity-pathology continuum model. Brain Research Reviews, 22, 51-92.
74.
McFarland, D. J.
, Kostar, J., & Drew, W. G. (1978). Dorsal hippocampal lesions: Effects of preconditioning CS exposure on flavor aversion. Behavioral Biology, 22, 398-404.
75.
Means, L. W.
, Walker, D. W., & Isaacson, R. L. (1970). Facilitated single alternation go, no-go acquisition after hippocampectomy in the rat. Journal of Comparative and Physiological Psychology, 72, 278-285.
76.
Miller, J. S.
, Nonneman, A. J., Kelly, K. S., Neisewander, J. L., & Isaac, W. L. (1986). Disruption of neophobia, conditioned odor aversion, and conditioned taste aversion in rats with hippocampal lesions. Behavioral and Neural Biology, 45, 240-253.
77.
Miller, R. R.
(1970). Effects of environmental complexity on amnesia induced by electroconvulsive shock in rats. Journal of Comparative and Physiological Psychology, 71, 268-265.
78.
Milner, B.
(1968). Memory. In L. Weiskrantz (Ed.), Analysis of behavioral change. New York: Harper & Row.
79.
Misanin, J. R.
, Miller, R. R., & Lewis, D. J. (1968). Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace. Science, 160, 554-555.
80.
Morris, R.G.M.
(1981). Spatial localization does not require the presence of local cues. Learning and Motivation, 12, 239-260.
81.
Morris, R.G.M.
, Garrud, P., Rawlings, J., & O’Keefe, J. (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
82.
Muller, G. E.
, & Pilzecker, A. (1900). Experimentelle Beitrage zur Lehre vom Gedachtness [Experimental contributions to the study of memory]. Zeitschrift fur Psychologie, 1, 1-288.
83.
Murray, E. A.
, & Mishkin, M. (1998). Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and the hippocampus. Journal of Neuroscience, 18, 6568-6582.
84.
Nadel, L.
, & Moscovitch, M. (1997). Memory consolidation, retrograde amnesia and the hippocampal complex. Current Opinion in Neurobiology, 7, 217-227.
85.
Nauta, W.J.H.
(1986). Circuitous connections linking cerebral cortex, limbic system, and corpus striatum. In B. K. Doane & K. E. Livingston (Eds.), The limbic system: Functional organization and clinical disorders (pp. 43-54). New York: Raven Press.
86.
Nunn, J. A.
, Graydon, F. J., Polkey, C. E., & Morris, R. G. (1999). Differential spatial memory impairment after right temporal lobectomy demonstrated using temporal titration. Brain, 122, 47-59.
87.
Owen, A. M.
, Milner, B., Petrides, M., & Evans, A. C. (1996). Memory for object features versus memory for object location: A positronemission tomography study of encoding and retrieval processes. Proceedings of the National Academy of Sciences (USA), 93, 9212-9217.
88.
Papez, J. W.
(1937). A proposed mechanism of emotion. Archives of Neurology and Psychiatry, 38, 725-743.
89.
Paulsson, M.
(1992). Basement membrane proteins: Structure, assembly, and cellular interactions. Critical Reviews in Biochemical and Molecular Biology, 27, 93-127.
90.
Penfield, W.
, & Roberts, L. (1959). Speech and brain mechanisms. Princeton, NJ: Princeton University Press.
91.
Poletti, C. E.
(1986). Is the limbic system a limbic system? Studies of hippocampal efferents: Their functional and clinical applications. In B. K. Doane & K. E. Livingston (Eds.), The limbic system: Functional organization and clinical disorders (pp. 79-94). New York: Raven Press.
92.
Raphelson, A. C.
, Isaacson, R. L., & Douglas, R. J. (1965). The effect of distracting stimuli on the runway performance of limbic damaged rats. Psychonomic Science, 3, 483-484.
93.
Ridley, R. M.
, Pearson, C., Kershaw, T. R., Hodges, H., MacLean, C. J., Hoyle, C., et al. (1997). Learning impairment induced by lesion of the CA1 field of the primate hippocampus: Attempts to ameliorate the impairment by transplantation of fetal tissue. Experimental Brain Research, 115, 83-94.
94.
Roberts, W. W.
, Dember, W. N., & Brodwick, M. (1962). Alternation and exploration in rats with hippocampal lesions. Journal of Comparative and Physiological Psychology, 55, 695-700.
95.
Schmajuk, L.
, Spear, N. E., & Isaacson, R. L. (1983). Absence of over-shadowing in rats with hippocampal lesions. Physiological Psychology, 11, 59-62.
96.
Schmaltz, L. W.
, & Isaacson, R. L. (1966). The effect of preliminary training conditions upon DRL performance in the hippocampectomized rat. Physiology and Behavior, 1, 175-182.
97.
Schmaltz, L. W.
, & Isaacson, R. L. (1967). Effects of bilateral hippocampal destruction on the acquisition and extinction of an operant response. Physiology and Behavior, 2, 291-298.
98.
Schmaltz, L. W.
, & Isaacson, R. L. (1968). Effect of blindness of DRL-20 performances exhibited by animals with hippocampal destruction. Psychonomic Science, 11, 241-242.
99.
Schmaltz, L. W.
, & Theios, J. (1972). Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits (Oryctolagus cuniculus). Journal of Comparative and Physiological Psychology, 79, 328-333.
100.
Scoville, W. B.
(1949). Selective cortical undercutting as a means of modifying and studying the frontal lobe function in man. Journal of Neurosurgery, 6, 65-65.
101.
Scoville, W. B.
, Dunsmore, R. H., Liberson, W. T., Henry, C. E., & Pepe, A. (1953). Observations on medial temporal lobotomy and uncotomy in the treatment of psychotic states. Research Publications–Association of Nervous and Mental Disease, 31, 347-369.
102.
Scoville, W. B.
, & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry, 20, 11-21.
103.
Shapiro, M.
(2001). Plasticity, hippocampal place cells, and cognitive maps. Archives of Neurology, 58, 874-881.
104.
Shors, T. J.
, & Matzel, L. D. (1997). Long-term potentiation: What’s learning got to do with it?Behavioral and Brain Sciences, 20, 597-655.
105.
Socci, D. J.
, Sandberg, P. R., & Arendash, G. W. (1995). Nicotine enhances Morris water maze performance of young and aged rats. Neurobiology of Aging, 16, 857-860.
106.
Solomon, P. R.
(1977). Role of the hippocampus in blocking and conditioned inhibition of the rabbit’s nictitating membrane response. Journal of Comparative and Physiological Psychology, 91, 407-417.
107.
Solomon, P. R.
, & Moore, J. W. (1975). Latent inhibition and stimulus generalization of the classically conditioned nictitating membrane response in rabbits (Oryclolagus cuniculus) following dorsal hippocampal ablation. Behavioral Neuroscience, 89, 1192-1203.
108.
Spear, N.
, McKinzie, D. L., & Arnold, M. (1994). Suggestions from the infant rat about brain dysfunction and memory. In J. Delacour (Ed.), The memory system of the brain. Singapore: World Scientific.
109.
Spear, N. E. (1988). Infantile learning and memory in the rat. Presidential address, International Society for Developmental Psychobiology, Toronto, Canada.
110.
Stanley-Jones, D.
(1957). Posture and the rhinencephalon. Journal of Nervous and Mental Disease, 125, 591-598.
111.
Stone, C. P.
, & Bakhtiari, A. B. (1956). Effects of electroconvulsive shock on maze relearning by albino rats. Journal of Comparative and Physiological Psychology, 49, 318-320.
112.
Strelow, E. R.
(1985). What is needed for a theory of mobility–Lessons from the blind. Psychological Review, 92, 226-248.
113.
Strong, P. N. Jr.
(1978). The effect of cul length and hippocampal lesions on maze learning in the rat. Pavlovian Journal of Biological Science, 13, 246-250.
114.
Teitelbaum, H.
, & Milner, P. M. (1963). Activity changes following partial hippocampal lesions in rats. Journal of Comparative and Physiological Psychology, 56, 284-289.
115.
Votaw, C. L.
(1957). The hippocampus as a supplemental motor area. Anatomical Record, 127, 382-383.
116.
Votaw, C. L.
(1959). Certain anatomical and functional relations of the cornu Ammonis of the macaque monkey. Journal of Comparative Neurology, 122, 353-382.
117.
Whishaw, I. Q.
(1998). Place learning in hippocampal rats and the path integration hypotheses. Neuroscience and Biobehavioral Reviews, 22, 209-220.
118.
Whishaw, I. Q.
, Cassel, J. C., & Jarrard, L. E. (1995). Rats with fimbria-fornix lesions display a place response in swimming pool: A dissociation between getting there and knowing where. Journal of Neuroscience, 15, 5779-5788.
119.
Whishaw, I. Q.
, & Jarrard, L. E. (1996). Evidence for extrahippocampal involvement in place learning and hippocampal involvement in path integration. Hippocampus, 6, 513-524.
120.
Wickelgren, W. O.
, & Isaacson, R. L. (1963). Effect of introduction of an irrelevant stimulus on runway performance of the hippocampectomized rat. Nature, 200, 48-50.
121.
Winocur, G.
, Rawlins, J.N.P., & Gray, J. A. (1987). The hippocampus and conditioning to contextual cues. Behavioral Neuroscience, 101, 717-725.
122.
Wozniak, W.
(1999). Multipotent stem cells in the adult mammalian central nervous system. Folia Morph (Warsz), 58(3Suppl 2), 57-63.
123.
Zhong, Y.-M.
, Nishijo, H., Uwano, T., Tamura, R., Kawanishi, K., & Ono, T. (2000). Red ginseng ameliorated place navigation in young rats with hippocampal lesions and aged rats. Physiology and Behavior, 69, 511-525.
