Although gender differences exist for intestinal absorption of nutrients and drugs, the possible role estradiol may play in modulating nutrient transport has not been established. Therefore, small intestine glucose transport was measured 1 week after administering estradiol to ovariectomized rats fed diets high in carbohydrate (C) or protein (P). Rats treated with estradiol ate 21% less (P < 0.05) and lost body mass (7%; P < 0.05) but did not have smaller intestines. Administration of estradiol increased rates of glucose transport, but only when the rats were fed the C diet. These findings indicate that estradiol causes a disconnect between food intake and the dimensions and nutrient transport capacities of the small intestine. Furthermore, the responses to estradiol are influenced by diet composition, are not of the same magnitude for rats and dogs, and can be predicted to affect systemic availability of nutrients and drugs.
FerrarisRP, DiamondJ.Regulation of intestinal sugar transport. Physiol Rev77:257–302, 1997.
2.
FerrarisRP, CaoQX, PrabhakaramS.Chronic but not acute energy restriction increases intestinal nutrient transport in mice. J Nutr131:779–786, 2001.
3.
CasirolaDM, RifkinB, TsaiW, FerrarisRP. Adaptation of intestinal nutrient transport to chronic caloric restriction in mice. Am J Physiol271:G192–G200, 1996.
4.
MunizR, BurguilloL, del CastilloJR. Effect of starvation on neutral amino acid transport in isolated small-intestinal cells from guinea pigs. Pflugers Arch423:59–66, 1993.
5.
RayoJM, EstebanS, TurJA. Effect of starvation on the in vivo intestinal absorption of sugars and amino acids in young chickens (Gallus domesticus). Arch Int Physiol Biochim Biophys100:155–158, 1992.
6.
GilbertWR, FrankBH, GavinJRIII, GingerichRL. Characterization of specific pancreatic polypeptide receptors on basolateral membranes of the canine small intestine. Proc Natl Acad Sci U S A85:4745–4749, 1988.
7.
CoxHM. Peptidergic regulation of intestinal ion transport: a major role for neuropeptide Y and the pancreatic polypeptides. Digestion59:395–399, 1998.
8.
BarbezatGO, ReasbeckPG. Effects of bombesin, calcitonin, and enkephalin on canine jejunal water and electrolyte transport. Dig Dis Sci28:273–277, 1983.
9.
BarbezatGO, ReasbeckPG. Somatostatin inhibition of glucagon-stimulated jejunal secretion in the dog. Gastroenterology81:471–474, 1981.
10.
HirshAJ, CheesemanCI. Cholecystokinin decreases intestinal hexose absorption by a parallel reduction in SGLT1 abundance in the brush-border membrane. J Biol Chem273:14545–14549, 1998.
11.
HirshAJ, TsangR, KammilaS, CheesemanCI. Effect of cholecystokinin and related peptides on jejunal transepithelial hexose transport in the Sprague-Dawley rat. Am J Physiol271:G755–G761, 1996.
12.
BirdAR, CroomWJJr, FanYK, DanielLR, BlackBL, McBrideBW, EisenEJ, BullLS, TaylorIL. Jejunal glucose absorption is enhanced by epidermal growth factor in mice. J Nutr124:231–240, 1994.
13.
SchwartzMZ, StorozukRB. The influence of gastrin on gastrointestinal function. J Pediatr Surg21:1123–1127, 1986.
14.
AndrewsNJ, Rinno-BarmadaS, BurdettK, ElderJB. Effects of porcine gastric fundic factor, somatostatin, substance P, glucagon, neurotensin, bombesin, VIP, motilin, and pentagastrin on jejunal glucose absorption in the rat. Gut24:326–332, 1983.
15.
ThomasML, XuX, NorfleetAM, WatsonCS. The presence of functional estrogen receptors in intestinal epithelial cells. Endocrinology132:426–430, 1993.
SinghR, NagapaulJP, MajumdarS, ChakravartiRN, DhallGI. Effects of 17 beta-estradiol and progesterone on intestinal digestive and absorptive functions in ovariectomized rats. Biochem Int10:777–786, 1985.
18.
NagpaulJP, SinghR, AmmaMK, MajumdarS.Effect of a steroidal oral contraceptive on intestinal absorptive functions in proteins deficient rat. Biochem Int10:273–281, 1985.
19.
O'LoughlinPDMorrisHA. Oestrogen deficiency impairs intestinal calcium absorption in the rat. J Physiol511:313–322, 1998.
20.
ColinEM, Van Den BerndGJ, Van AkenM, ChristakosS, De JongeHR, DelucaHF, PrahlJM, BirkenhagerJC, BuurmanCJ, PolsHA, Van LeeuwenJP. Evidence for involvement of 17 beta-estradiol in intestinal calcium absorption independent of 1,25-dihydroxyvitamin D3 level in the rat. J Bone Miner Res14:57–64, 1999.
21.
KaluDN, ChenC.Ovariectomized murine model of postmenopausal calcium malabsorption. J Bone Miner Res14:593–601, 1999.
22.
ArjmandiBH, HollisBW, KaluDN. In vivo effect of 17 beta-estradiol on intestinal calcium absorption in rats. Bone Miner26:181–189, 1994.
23.
ten BolscherM, de Valk-de RooGW, BartoR, van der VijghWJ, NetelenbosJC. Oestrogen has no short-term effect on intestinal strontium absorption in healthy postmenopausal women. Clin Endocrinol (Oxf) 50:387–392, 1999.
24.
CoudrayC, GaumetN, BellangerJ, CoxamV, BarletJP, RayssiguierY.Influence of age and hormonal treatment on intestinal absorption of magnesium in ovariectomised rats. Magnes Res12:109–114, 1999.
25.
HaouariM, Haouari-OukerroF, AlguemiC, NagatiK, ZouaghiH, KamounA.Effects of oestradiol-17 beta on small intestine iron absorption and iron uptake into blood and liver. Horm Metab Res26:53–54, 1994.
26.
Dijkgraaf-ten BolscherM, NeeleSJ, BartoR, van der VijghWJ, NetelenbosJC. Effect of estrogen on intestinal strontium absorption in postmenopausal women. Maturitas36:195–201, 2000.
27.
MaurasN, VieiraNE, YergeyAL. Estrogen therapy enhances calcium absorption and retention and diminishes bone turnover in young girls with Turner's syndrome: a calcium kinetic study. Metabolism46:908–913, 1997.
28.
OrihuelaD, CamovaleCE, MontiJA, CarrilloMC. Sex-related differences in the effect of aluminum on calcium transport in the small intestine of the rat. Toxicol Lett85:165–171, 1996.
29.
LampeJW, FredstromSB, SlavinJL, PotterJD. Sex differences in colonic function: a randomised trial. Gut34:531–536, 1993.
30.
WallisIR, BalnaveD.The influence of environmental temperature, age and sex on the digestibility of amino acids in growing broiler chickens. Br Poult Sci25:401–407, 1984.
31.
BeierleI, MeibohmB, DerendorfH.Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther37:529–547, 1999.
32.
ThurmannPA, HompeschBC. Influence of gender on the pharmacokinetics and pharmacodynamics of drugs. Int J Clin Pharmacol Ther36:586–590, 1998.
33.
GleiterCH, Gundert-RemyU.Gender differences in pharmacokinetics. Eur J Drug Metab Pharmacokinet21:123–128, 1996.
34.
KashubaAD, NafzigerAN. Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs. Clin Pharmacokinet34:203–218, 1998.
35.
NeilsenKK, BuddingtonKK, RaunK, HansenTK, BuddingtonRK. Absorption and systemic availability of two synthetic growth hormone secretogogues and transport of glucose by the proximal small intestine of anestrus dogs after administering estradiol. J Comp Physiol173:61–67, 2003.
36.
American Institute of Nutrition. Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J Nutr 107:1340–1348, 1977.
37.
ArjmandiBH, KhalilDA, HollisBW. Ipriflavone, a synthetic phytoestrogen, enhances intestinal calcium transport in vitro. Calcif Tissue Int67:225–229, 2000.
38.
KarasovWH, DiamondJM. A simple method for measuring intestinal solute uptake in vitro. J Comp Physiol152:105–116, 1983.
39.
BurgerHG. Physiological principles of endocrine replacement: estrogen. Horm Res 56(Suppl l):82–85, 2001.
40.
GearyN, AsarianL.Cyclic estradiol treatment normalizes body weight and test meal size in ovariectomized rats. Physiol Behav67:141–147, 1999.
41.
BlevinsGTJr, McCulloughSS, WilbertTN, IsomRM, ChowdhuryP, MillerST. Estradiol alters cholecystokinin stimulus-response coupling in rat pancreatic acini. Am J Physiol275:G993–G998, 1998.
42.
TangokuA, DoiR, ChowdhuryP, BlevinsGTJr, PasleyJN, RayfordPL. Exogenous administration of estradiol and cholecystokinin alters exocrine pancreatic function in rats. Int J Pancreatol13:81–86, 1993.
43.
HayaseK, TanakaM, TujiokaK, HiranoE, HabuchiO, YokogoshiH.17-Beta-estradiol affects brain protein synthesis rate in ovariectomized female rats. J Nutr131:123–126, 2001.
44.
SahlinL, ElgerW, AkerbergS, MasironiB, ReddersenG, SchneiderB, SchwarzS, FreyschussB, ErikssonH.Effects of estradiol and estradiol sulfamate on the uterus of ovariectomized or ovariectomized and hypophysectomized rats. J Steroid Biochem Mol Biol74:99–107, 2000.
45.
AlbertDJ, JonikRH, GorzalkaBB, NewloveT, WebbB, WalshML. Serum estradiol concentration required to maintain body weight, attractivity, proceptivity, and receptivity in the ovariectomized female rat. Physiol Behav49:225–231, 1991.
46.
PicottoG, VazquezG, BolandR.17 Beta-oestradiol increases intracellular Ca2+ concentration in rat enterocytes: potential role of phospholipase C-dependent store-operated Ca2+ influx. Biochem J339:71–77, 1999.
47.
MaguireD, MacNamaraB, CuffeJE, WinterD, DoolanCM, UrbachV, O'SullivanGC, HarveyBJ. Rapid responses to aldosterone in human distal colon. Steroids64:51–63, 1999.
48.
McNamaraB, WinterDC, CuffeJ, TaylorC, O'SullivanGC, HarveyBJ. Rapid activation of basolateral potassium transport in human colon by oestradiol. Br J Pharmacol131:1373–1378, 2000.
49.
DiamondJM, KarasovWH. Effect of dietary carbohydrate on monosaccharide uptake by mouse small intestine in vitro. J Physiol349:419–440, 1984.
50.
PanY, WongEA, BloomquistJR, WebbKEJr.Expression of a cloned ovine gastrointestinal peptide transporter (oPepT1) in Xenopus oocytes induces uptake of oligopeptides in vitro. J Nutr131:1264–1270, 2001.
51.
DyerJ, BarkerPJ, Shirazi-BeecheySP. Nutrient regulation of the intestinal Na+/glucose co-transporter (SGLT1) gene expression. Biochem Biophys Res Commun230:624–629, 1997.
52.
SharpPA, DebnamES, SraiSK. Rapid enhancement of brush border glucose uptake after exposure of rat jejunal mucosa to glucose. Gut39:545–550, 1996.
53.
HardinJA, WongJK, CheesemanCI, GallDG. Effect of luminal epidermal growth factor on enterocyte glucose and proline transport. Am J Physiol271:G509–G515, 1996.
54.
WalkerD, ThwaitesDT, SimmonsNL, GilbertHJ, HirstBH. Substrate upregulation of the human small intestinal peptide transporter, hPepT1. J Physiol507:697–706, 1998.
55.
ThamotharanM, BawaniSZ, ZhouX, AdibiSA. Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast. Metabolism48:681–684, 1999.
ThamotharanM, BawaniSZ, ZhouX, AdibiSA. Hormonal regulation of oligopeptide transporter pept-1 in a human intestinal cell line. Am J Physiol276:C821–C826, 1999.
58.
GoodladRA, PlumbJA, WrightNA. Epithelial cell proliferation and intestinal absorptive function during starvation and refeeding in the rat. Clin Sci (Lond)74:301–306, 1988.
59.
ThompsonCS, DebnamES. Starvation-induced changes in the autoradiographic localisation of valine uptake by rat small intestine. Experientia42:945–948, 1986.
60.
BassonMD, ModlinIM, FlynnSD, JenaBP, MadriJA. Independent modulation of enterocyte migration and proliferation by growth factors, matrix proteins, and pharmacologic agents in an in vitro model of mucosal healing. Surgery112:299–307, 1992.
61.
HoffMB, ChangWW, MakKM. Effect of estrogen on cell proliferation in colonic mucosa of the mouse. Virchows Arch B Cell Pathol Incl Mol Pathol35:263–273, 1981.
62.
HalaihelN, GerbaudD, VasseurM, AlvaradoF.Heterogeneity of pig intestinal d-glucose transport systems. Am J Physiol277:C1130–C1141, 1999.
63.
KellettGL, HelliwellPA. The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J350:155–162, 2000.
64.
LostaoMP, UrdanetaE, Martinez-AnsoE, BarberA, MartinezJA. Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett423:302–306, 1998.
65.
Jourd'heuilD, MeddingsJB. Oxidative and drug-induced alterations in brush border membrane hemileaflet fluidity, functional consequences for glucose transport. Biochim Biophys Acta1510:342–353, 2001.
66.
Jourd'HeuilD, VaananenP, MeddingsJB. Lipid peroxidation of the brush-border membrane: membrane physical properties and glucose transport. Am J Physiol264:G1009–G1015, 1993.
67.
SadowskiDC, GibbsDJ, MeddingsJB. Proline transport across the intestinal microvillus membrane may be regulated by membrane physical properties. Biochim Biophys Acta1105:75–83, 1992.
68.
ButznerJD, BrockwayPD, MeddingsJB. Effects of malnutrition on microvillus membrane glucose transport and physical properties. Am J Physiol259:G940–G946, 1990.
69.
MeddingsJB, DeSouzaD, GoelM, ThiesenS.Glucose transport and microvillus membrane physical properties along the crypt-villus axis of the rabbit. J Clin Invest85:1099–1107, 1990.
70.
SchwarzSM, BostwickHE, MedowMS. Estrogen modulates ileal basolateral membrane lipid dynamics and Na+-K+-ATPase activity. Am J Physiol254:G687–G694, 1988.
71.
SchwarzSM, WatkinsJB, LingSC, FayerJC, MoneM.Effects of ethinyl estradiol on intestinal membrane structure and function in the rabbit. Biochim Biophys Acta860:411–419, 1986.
72.
MolinaAS, PaladiniA, GimenezMS. Hormonal influence on lipid-protein interactions in biological membranes: lactation effects on alkaline phosphatase activity and intestinal brush border membrane properties in rat. Horm Metab Res29:159–163, 1997.
