The effects of mental and physical fatigue can significantly impact how we interact with our daily environment. Furthermore, these effects exhibit a high level of variance across individuals. Advances in technologies such as functional magnetic resonance imaging (fMRI) are offering new opportunities to characterize the effects of sleep deprivation on individuals. In this paper, we investigate the use of advanced fMRI modalities in resting wakefulness as correlated with performance on a spatial working memory task after sleep deprivation. Findings show that fatigue vulnerability to performance decrements on complex spatial working memory tasks in healthy participants can be predicted by fMRI images taken during resting wakefulness.
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