The effects of human immunodeficiency virus (HIV) infection on central nervous system function were studied with the P3a and P3b event-related brain potentials (ERPs) in patients with HIV compared to unaffected matched controls (n=14/group). All patients were on anti-viral medication for at least 2 months before testing. Auditory stimuli were employed in an easy 2-stimulus oddball discrimination task to obtain a typical P3b (P300) subcomponent. A 3-stimulus distractor paradigm also was employed in which the target/standard discrimination was very difficult, and an infrequent high-pitched tone non-target was presented to elicit the P3a subcomponent. Subjects responded only to the target stimulus in each task. P3a amplitude was significantly smaller for HIV compared to control subjects. No reliable P3b effects were obtained. The findings suggest that P3a rather than P3b may be a more sensitive measure of cognitive impairment in HIV patients on anti-viral medication.
GrantIAtkinsonHHesslelinkJREvidence for early central nervous system involvement in the acquired immunodeficiency syndrome AIDS and other human immunodeficiency virus HIV infections. Ann Int Med1987; 107: 828–836.
2.
LevyJKFernandezFHolmesVFGagenMPirozzoloFJ. Verbal-memory disturbance associated with HIV infection. J Clin Exp Neuropsychol1987; 9: 45.
3.
WilkieFEisdorferCMorganRLoewensteinDSzapocznikJ. Cognition in early human immunodeficiency virus infection. Arch Neurol1990; 7: 433–440.
4.
GoetheKMitchellJMarshallDNeuropsychological and neurological function of human immunodeficiency virus seropositive asymptomatic individuals. Arch Neurol1989; 46: 129–133.
5.
MillerESeinesOMcArthurJNeuropsychological performance in HIV-1-infected homosexual men: the multicenter AIDS cohort study MACS. Neurology1990; 40: 197–203.
6.
SeinesEMillerEMcArthurJHIV-1 infection: no evidence of cognitive decline during the asymptomatic stages. J Neurology1990; 40: 204–208.
7.
PolichJHerbstKL. P300 as a clinical assay: rationale, evaluation, and findings. Int J Psychophys2000; 38: 3–19.
8.
PolichJPitzerAPocetaJSMitlerMMDarkoDF. Neuroelectric assessment of HIV: EEG, ERP, and viral load. Intl J Psychophys2000; 38: 97–108.
9.
FeinGBigginsCAMacKayS. Alcohol abuse and HIV infection have additive effects on frontal cortex function as measured by auditory evoked potential P3a latency. Biol Psychiat1995; 37: 183–195.
10.
OlloCJohnsonRGrafmanJ. Signs of cognitive change in HIV disease: an event-related brain potential study. Neurology1991; 41: 209–215.
11.
SchroederMMHandelsmanLTorresLEarly and late cognitive event-related potentials mark stages of HIV-1 infection in the drug-user risk group. Biol Psychiat1994; 35: 54–69.
12.
FoxHSWeedMRHuitron-ResendizSAntiviral treatment normalizes neurophysiological but not movement abnormalities in simian immunodefiency virus-infected monkeys. J Clin Invest2000; 106: 37–45.
13.
DarkoDFMillerJCGallenCSleep electroencephalogram delta-frequency amplitude, night plasma level of tumor necrosis factor α, and human immunodeficiency virus infection. Proc Nat Acad Sci USA1995; 92: 12080–12084.
14.
PictonTW. The P300 wave of the human event-related potential. J Clin Neurophys1992; 9: 456–479.
15.
PolichJ. P300 in clinical applications. In: NiedermeyerELopes daSilva F, (eds). Electroencephalography: Basic Principles, Clinical Applications and Related Fields. 4th ed. Baltimore-Munich: Urban and Schwarzenberg; 1999: 1073–1091.
16.
CourchesneEKilmanBAGalambosRLincolnA. Autism: processing of novel auditory information assessed by event-related brain potentials. Electroencephalogr Clin Neurophysiol1984; 59: 238–248.
17.
KnightRT. Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalogr Clin Neurophysiol1984; 59: 9–20.
CourchesneEHillyardSAGalambosR. Stimulus novelty, task relevance and the visual evoked potential in man. Electroencephalogr Clin Neurophysiol1975; 39: 131–143.
20.
SquiresNKSquiresKCHillyardSA. Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalogr Clin Neurophysiol1975; 38: 387–401.
21.
SimonsRFGrahamFKMilesMAChenX. On the relationship of P3a and the Novelty-P3. Biol Psychol2001; 56: 207–218.
22.
SpencerKMDienJDonchinE. A componential analysis of the ERP elicited by novel events using a dense electrode array. Psychophysiology1999; 36: 409–414.
23.
FriedmanDSimpsonG. ERP amplitude and scalp distribution to target and novel events: effects of temporal order in young, middle-age, and older adults. Cogn Brain Res1994; 2: 49–63.
ComercheroMDPolichJ. P3a and P3b from typical auditory and visual stimuli. Clin Neurophysiol1999; 110: 24–30.
28.
DemiralpTAdemogluAComercheroMPolichJ. Wavelet analysis of P3a and P3b. Brain Topogr2001; 13: 251–267.
29.
SuwazonoSMachadoLKnightRT. Predictive value of novel stimuli modifies visual event-related potentials and behavior. Clin Neurophysiol2000; 111: 20–39.
30.
PolichJ. 2002. Neuropsychology of P3a and P3b: a theoretical overview. In: ArikanKMooreN, (eds). Advances in Electrophysiology in Clinical Practice and Research. Wheaton, IL: Kjellberg; 2002. In press.
31.
GoodinDSAminoffMJChernoffDNHollanderH. Long latency event-related potentials in patients infected with human immunodeficiency virus. Ann Neurol1990; 27: 414–419.
32.
SemlitschHVAndererPSchusterPPresslichO. A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology1986; 23: 695–703.
33.
PolichJKokA. Cognitive and biological determinants of P300: an integrative review. Biol Psychol1995; 41: 103–146.
34.
PolichJ. P300 clinical utility and control of variability. J Clin Neurophysiol1998; 15: 14–33.
35.
KnightRT. Contribution of human hippocampal region to novelty detection. Nature1996; 383: 256–259.
36.
FletcherDJRazJFeinG. Intra-hemispheric alpha coherence decreases with increasing cognitive impairment in HIV patients. Electroencephalogr Clin Neurophysiol1997; 102: 286–294.
37.
HardenCDarasMTuchmanAKoppelB. Low amplitude EEGs in demented AIDS patients. Electroencephalogr Clin Neurophysiol1993; 87: 54–56.
38.
IntriligatorJPolichJ. On the relationship between EEG and P300 variability. Intl J Psychophys1995; 20: 59–74.
39.
PolichJ. On the relationship between EEG and P300: individual differences, aging, and ultradian rhythms. Intl J Psychophys1997; 26: 299–317.
40.
PolichJ. EEG and ERP Assessment of normal aging. Electroencephalogr Clin Neurophysiol1997; 104: 228–243.
41.
SpencerKMPolichJ. Post-stimulus EEG spectral analysis and P300: attention, task, and probability. Psychophysiology1999; 36: 220–232.
