Recently, it has been reported that IL-17 may be involved in allergic reaction. Sublingual immunotherapy (SLIT) is the unique curative treatment for allergic rhinitis. This study aims at investigating whether one course of birch SLIT could affect serum IL-17 levels. The findings provided show that some IL-17 producer patients had a reduction of serum IL-17 levels after one SLIT course. Therefore, this preliminary study shows that a single pre-seasonal SLIT course may induce a significant decreasing trend in serum IL-17 levels; further study should be carried out to define the role exerted by IL-17 in allergic rhinitis.
Schmidt-WeberC.B., AkdisM., AkdisC.A.Th17 cells in the big picture of immunology. J Allergy Clin Immunol2007; 120: 247–54.
2.
HellingsP.W., KasranA., LiuZ., VandekerckhoveP., WuytsA., OverberghL.IL-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Resp Cell Mol Biol2003; 28: 42–50.
3.
SergejevaS., IvanovS., LotvallJ., LindenA.IL-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am J Resp Cell Mol Biol2005; 33: 248–53.
4.
CiprandiG., BuscagliaS., PesceG.P., VillaggioB., BagnascoM., CanonicaG.W.Allergic subjects express intercellular adhesion molecule-1 (ICAM-1 or CD54) on epithelial cells of conjunctiva after allergen challengeJ Allergy Clin Immunol1993; 91: 783–91.
5.
BousquetJ., LockeyR.F., MailingH.J. WHO position paper. Allergen immunotherapy: therapeutic vaccines for allergic disease. Allergy1998; 531–42.
6.
BousquetJ., KhaltaevN., CruzA.A., DenburgJ., FokkensW.J., TogiasA.Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 Update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy2008; 63: 8–160.
