Alzheimer's disease (AD) is widely identified as the most common cause of sporadic dementia. Its aetiology is still debated, as despite several hypotheses, different factors seem to play a role in its establishment and development. Recent studies have proposed a possible preventing role of nutrition. The weight loss typical of earlier phase of disease and the finding of malnutrition as a common trait between patients leads to hypothesize that a supplementation of specific nutrients seems to be useful and effective in terms of improvement of cognitive functions. Malnourished patients show also altered parameters when investigating inflammation markers: for example, hyperhomocysteinemia is a typical finding in elderly affected by dementia, and it can be prevented and corrected by using a proper nutrients supplementation. Pro-inflammatory state can be reduced with supplementation of polyunsaturated fatty acids, vitamins of the group B and phosphatidylserine, that can act reducing IL-1β (pro-inflammatory cytokine) and improving IL-10 (anti-inflammatory cytokine) synthesis. While investigating the role of nutrition, it seems to be deeply linked with genetic; a genetic onset AD-related could be latent and can be influenced by nutritional attitude. AD can be considered a sort of latent clinical condition that would disclose or not, depending also on micro-environment and nutritional parameters. The genetic expression can be influenced by assumptions or not of specific nutrients, with the promotion of different pro- or anti-inflammatory settings. The specific role of each micronutrient (in particular vitamins) and trace elements still needs to be punctuated, as they are involved in a pool of different reactions. Also genes acts not independently but in an interconnected pattern, in which the role of a single gene needs to be cleared, depending on others. This complex system of predisposing conditions and a possible role of nutrition as modulator of the inflammatory state is the object of this review.
PrinceMBryceRFerriC. The benefits of early diagnosis and intervention. Alzheimer report 2011.
2.
LoyCSchneiderL. Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev2006; 25(1):CD001747.
3.
AreosaSASherriffFMcShaneR. Memantine for dementia. Cochrane Database Syst Rev2006; 19(2):CD003154.
4.
TanziRE. A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. J Clin Invest1999; 104(9): 1175–9.
5.
GoateAChartier-HarlinMCMullanM. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature1991; 349(6311):704–6.
6.
SherringtonRRogaevEILiangY. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature1995; 375(6534):754–60.
7.
SelkoeDJPodlisnyMB. Deciphering the genetic basis of Alzheimer's disease. Annu Rev Genomics Hum Genet2002; 3:67–99.
8.
CacabelosRMartinezRFernandez-NovoaL. Genomics of dementia. Int J Alzheimers Dis2012; 2012:518901.
9.
JunGNajACBeechamGW. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol2010; 67(12):1473–84.
10.
RajTShulmanJMKeenanBTChibnikLBEvansDABennettDAStrangerBEDe JagerPL. Alzheimer disease susceptibility loci: Evidence for a protein network under natural selection. Am J Hum Genet2012; 90(4):720–6.
11.
JonesLHolmansPAHamshereML. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One2010; 5(11):e13950.
12.
BashaMRWeiWBakheetSABenitezNSiddiqiHKGeYWLahiriDKZawiaNH. The fetal basis of amyloidogenesis: Exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci2005; 25(4):823–9.
13.
WuJBashaMRBrockB. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD. J Neurosci2008; 28(1):3–9.
14.
ElsonJLHerrnstadtCPrestonGThalLMorrisCMEdwardsonJABealMFTurnbullDMHowellN. Does the mitochondrial genome play a role in the etiology of Alzheimer's disease?Hum Genet2006; 119(3):241–54.
15.
GrazinaMPratasJSilvaFOliveiraSSantanaIOliveiraC. Genetic basis of Alzheimer's dementia: Role of mtDNA mutations. Genes Brain Behav2006; 5(S):92–107.
16.
CarrieriGBonafeMDeLM. Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease. Hum Genet2001; 108(3):194–8.
17.
SparksDLScheffSWHunsakerJCIIILiuHLandersTGrossDR. Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol. Exp Neurol1994; 126(1):88–94.
18.
RefoloLMMalesterBLaFrancoisJBryant-ThomasTWangRTintGSSambamurtiKDuffKPappollaMA. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis2000; 7(4):321–31.
19.
TerryRD. Alzheimer's disease and the aging brain. J Geriatr Psychiatry Neurol2006; 19(3): 125–8.
20.
WurtmanRJUlusIHCansevMWatkinsCJWangLMarzloffG. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res2006; 1088(1):83–92.
21.
van der BeekEMKamphuisPJ. The potential role of nutritional components in the management of Alzheimer's Disease. Eur J Pharmacol2008; 585(1): 197–207.
22.
SongCMankuMSHorrobinDF. Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. J Nutr2008; 138(5):954–63.
23.
EngelhartMJGeerlingsMIRuitenbergAvan SwietenJCHofmanAWittemanJCBretelerMM. Diet and risk of dementia: Does fat matter? The Rotterdam Study. Neurology2002; 59(12):1915–21.
24.
MorganTEXieZGoldsmithS. The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience1999; 89(3):687–99.
25.
LuchsingerJATangMXSheaSMayeuxR. Caloric intake and the risk of Alzheimer disease. Arch Neurol2002; 59(8): 1258–63.
26.
LeeJDuanWLongJMIngramDKMattsonMP. Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J Mol Neurosci2000; 15(2):99–108.
27.
BelminJ. Practical guidelines for the diagnosis and management of weight loss in Alzheimer's disease: A consensus from appropriateness ratings of a large expert panel. J Nutr Health Aging2007; 11(1):33–7.
28.
WeuveJKangJHMansonJEBretelerMMWareJHGrodsteinF. Physical activity, including walking, and cognitive function in older women. JAMA2004; 292(12):1454–61.
29.
GilletteGSAbellan vanKGAlixE. IANA (International Academy on Nutrition and Aging) Expert Group: Weight loss and Alzheimer's disease. J Nutr Health Aging2007; 11(1):38–48.
30.
SaragatBBuffaRMereuESuccaVCabrasSMereuRMVialeDPutzuPFMariniE. Nutritional and psycho-functional status in elderly patients with Alzheimer's disease. J Nutr Health Aging2012; 16(3):231–6.
31.
BourreJM. Effects of nutrients (in food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 1: Micronutrients. J Nutr Health Aging2006; 10(5):377–85.
32.
MaloufMGrimleyEJAreosaSA. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database Syst Rev2003; (4):CD004514.
33.
FerlandG. Vitamin K and the nervous system: An overview of its actions. Adv Nutr2012; 3(2):204–12.
34.
HuebbePLodgeJKRimbachG. Implications of apolipoprotein E genotype on inflammation and vitamin E status. Mol Nutr Food Res2010; 54(5):623–30.
35.
EgertSRimbachG. Which sources of flavonoids: Complex diets or dietary supplements?Adv Nutr2011; 2(1):8–14.
36.
da SilvaSI LopesVellasBElemansSLuchsingerJKamphuisPYaffeKSijbenJGroenendijkMStijnenT. Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis. Alzheimers Dement2014; 10(4):485–502.
37.
van GelderBMTijhuisMKalmijnSKromhoutD. Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: The Zutphen Elderly Study. Am J Clin Nutr2007; 85(4): 1142–7.
38.
AlessandriJMGuesnetPVancasselSAstorgPDenisILangelierBAidSPoumes-BallihautCChampeil-PotokarGLavialleM. Polyunsaturated fatty acids in the central nervous system: Evolution of concepts and nutritional implications throughout life. Reprod Nutr Dev2004; 44(6):509–38.
39.
MuskietFAFokkemaMRSchaafsmaABoersmaERCrawfordMA. Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials. J Nutr2004; 134(1): 183–6.
40.
MeyerBJMannNJLewisJLMilliganGCSinclairAJHowePR. Dietary intakes and food sources of omega-6 and omega-3 polyunsaturated fatty acids. Lipids2003; 38(4):391–8.
41.
KalmijnSvan BoxtelMPOckeMVerschurenWMKromhoutDLaunerLJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology2004; 62(2):275–80.
42.
MorrisMCEvansDATangneyCCBieniasJLWilsonRS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol2005; 62(12):1849–53.
43.
HuNYuJTTanLWangYLSunLTanL. Nutrition and the risk of Alzheimer's disease. Biomed Res Int2013; 2013:524820.
44.
PocernichCBLangeMLSultanaRButterfieldDA. Nutritional approaches to modulate oxidative stress in Alzheimer's disease. Curr Alzheimer Res2011; 8(5):452–69.
45.
ChoiHIParkHHLeeKYChoiNYYuHJLeeYJParkJHuhYMLeeSHKohSH. Coenzyme Q10 restores amyloid beta-inhibited proliferation of neural stem cells by activating the PI3K pathway. Stem Cells Dev2013; 22(15):2112–20.
46.
DumontMIKipianiKYuFWilleEKatzMCalingasanNYGourasGKLinMTBealMF. Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis2011; 27(1):211–23.
47.
LinLHuangQXYangSSChuJWangJZTianQ. Melatonin in Alzheimer's disease. Int J Mol Sci2013; 14(7): 14575–93.
