Plasma levels of immunoreactive parathormone (iPTH), immunoreactive calcitonin (iCT) and prostaglandins (PGE2) were measured by RIA in 115 patients with bronchogenic carcinoma. In 37 of these cases the following hormones were also assayed: adrenocorticotropic hormone (ACTH), cortisol, plasma renin activity (PRA), aldosterone, prolactin, human growth hormone (HGH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH) human chorionic gonadotropin (HCG), progesterone (P), an-drostenedoone (A), testosterone (T), estradiol (E2) and dehydropiandrosterone sulphate (DHAS). High serum levels of many hormone-like substances and hormones were found and the levels of certain hormones varied in some cases according to the clinical evolution of the disease and the response to therapy.
AzzopardiJ.G., FreemanE., PooleG.Endocrine and metabolic disorders in bronchial carcinoma.Brit Med J1970; 4: 528–9.
2.
CraggJ.Endocrine and metabolic disorders in bronchial carcinoma.Brit Med J1971; 2: 110–1.
3.
LevineR.J., MetzS.A.A classification of ectopic hormone producing tumours.Ann NY Acad Sci1974; 230: 533–46.
4.
YesnerR.Spectrum of lung cancer and ectopic hormones.Pathol Annu1978; 13: 217–40.
5.
BergerC.L., GoodwinG., MendelsohnG.. Endocrine-related biochemistry in the spectrum of human lung carcinoma.J Clin Endocrinol Metab1981; 53: 422–9.
6.
BersonS.A., YalowR.S.Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia and bronchogenic carcinoma.Science1966; 154: 907–9.
7.
SherwoodL.M., O'RiordanJ.C., AurbachG.D., PottsJ.T.Jr., Production of parathyroid hormone by nonparathyroid tumors.J Clin Endocrinol Metab1967; 27: 140–6.
8.
BensonR.C.Jr., RiggsB.L., PickardN.M., ArnaudC.D.Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease.Am J Med1974; 56: 821–6.
9.
DreznerM.K., NeelonF.A., CurtisH.B., LebovitzH.E.Renal cyclic adenosine monophosphate: an accurate index of parathyroid function.Metabolism1976; 25: 1103–12.
10.
SilvaO.L., BeckerK.L., PrimackA., DoppmanJ., SniderR.H.Ectopic secretion of calcitonin by oat-cell carcinoma.New Engl J Med1974; 290: 1122–4.
11.
SilvaO.L., BeckerK.L., PrimackA., DoppmanJ., SniderR.H.Hypercalcitoninemia in bronchogenic cancer: evidence for thyroid origin of the hormone.Jama1975; 234: 183–5.
12.
EllisonM., WoodhouseD., HillyardC.. Immunor-eactive calcitonin production by human lung carcinoma cells in culture.Brit J Cancer1975; 32: 373–9.
CareyV.C.I.The incidence of hypercalcemia in association with bronchogenic carcinoma.Am Rev Respir Dis1966; 93: 584–6.
16.
FranciniG., GalliM.Hypercalcemia and urinary excretion of cyclic AMP in bronchogenic carcinoma.World J Surg1977; 1: 527–34.
17.
RaiszL.G., MundyG.R., ElionG.Hypercalcemia of neoplastic disease. In: CoppD.H., TalmageR.V., eds. Endocrinology of calcium metabolism.Amsterdam: Excerpta Medica, 1978; 64–70.
18.
FiskenR.A., HeathD.A., BoldA.M.Hypercalcemia. A hospital survey.Quart J Med1980; 49: 405–18.
19.
SeyberthH.W., SegreG.V., MorganJ.L., SweetmanB.J., PottsJ.T., OatesJ.A.Prostaglandins mediators of hypercalcemia associated with certain types of cancer.New Engl J Med1975; 293: 1278–83.
20.
DowsettM., EastyG.L., PowerT.J., EastyD.M., NevilleA.M.Human breast tumor-induced osteolysis and prostaglandins.Prostaglandins1976; 11: 447–60.
21.
GewirtzG., YalowR.S.Ectopic ACTH production in carcinoma of the lung.J Clin Invest1974; 53: 1022–32.
22.
AzzopardiJ.G., WilliamsE.A.Pathology of nonendocrine tumours associated with Cushing's syndrome.Cancer1968; 22: 274–86.
23.
WolfsenA.R., OdellW.D.Pro-ACTH: use for early detection of lung cancer.Am J Med1979; 66: 765–72.
24.
FuscoF.E., RosenS.W.Gonadotropin-producing anaplastic largecell carcinomas of the lung.New Engl J Med1966; 275: 507–15.
25.
FaimanC., ColwellJ.A., RyanR.J., HershmanJ.M., ShieldsT.W.Gonadotropin secretion from a bronchogenic carcinoma. Demonstration by radioimmunoassay.New Engl J Med1967; 277: 1395–9.
26.
RosenS.F., BeckerC.E., SchlaffS., EastonJ., GluckC.M.Ectopic gonadotropin production before clinical recognition of bronchogenic carcinoma.New Engl J Med1968; 279: 640–48.
27.
BrodenL.E., RosenS.W., WeintaubB.D.. Placental proteins in broncogenic carcinoma. Progress in cancer research and therapy. In: MuggiaF.M., RozencweigM., eds. Lung Cancer: progress in therapeutic research.New York: Raven Press, 1979; 217–55.
28.
OdellW.D., WolfsenA.R., BachelotI., HiroseF.M.Ectopic production of lipoprotein by cancer.Am J Med1979; 66: 631–8.
29.
PontA., SheltonR., OldellW.S., WilsonC.B.Prolactin-secreting tumours in men: surgical cure.Ann Int Med1979; 91: 211–3.
30.
SchwartzW.B., BennetW., CurelopS., BartterP.C.A syndrome of renal sodium loss and hyponatremia, probably resulting from inappropriate excretion of antidiuretic hormone.Am J Med1957; 23: 529–42.
31.
GroppC., HavemannK., ScheverA.Ectopic hormones in lung cancer patients.Cancer1980; 46: 347–54.
32.
BroadusA.E., MahatteyJ.E., BartterF.C., NeerR.M.Nephrogenous cyclic adenosine monophosphate and a parathyroid function test.J Clin Invest1977; 60: 771–83.
DayR.P., LuetscherJ.A., ZagerP.G.Big renin: identification, chemical properties and clinical implication.Am J Car1976; 37: 667–73.
35.
DunnM.J., StaleyR.S., HarrisonM.Characterization of prostaglandin production in tissue culture of rat renal medullary cells.Prostaglandins1976; 12: 37–49.
36.
AikenJ.W., VaneJ.R.Intrarenal prostaglandin release attenuates the renal vasoconstriction activity of angiotensin.J Pharmac Exp Ther1973; 184: 678–87.
37.
Herbaczinski-LedroK., VaneJ.R.Contribution of intrarenal generation of prostaglandin to autoregulation of renal blood flow in the dog.Circulation Res1973; 33: 428–36.
