Experimental determination of rupture pressure and stress of adventitia of human middle cerebral arteries

Abstract

Background

Intracranial arterial dissections might be attributed to the particular biomechanical properties of their specific layers. Also, knowledge of adventitia properties would be crucial in the context of intracranial balloon angioplasty.

Aims

The purpose of this work was to determine the rupture pressure of separated adventitia and compare it to intact cerebral arterial segments.

Methods

Brain specimens were harvested from 14 autopsy subjects (age range from 23 to 86 years). Pressure-inflation tests were conducted on proximal segments of middle cerebral arteries and separated adventitia layers from contralateral arteries to assess the rupture pressure values.

Results

The averaged rupture pressure of adventitia layers was 1.41 SD 0.25 atm (1072 SD 190 mmHg), whereas for intact arterial segments it was 2.32 SD 0.70 atm (1763 SD 532 mmHg) and diminished with age according to nonlinear regression trends. The difference beetween the aformentioned rupture pressures was positively correlated with rupture pressure of intact arterial segments (R²= 0.88; p < 0.001).

Conclusions

The obtained experimental results indicate a leading role of adventitia in building arterial strength under supraphysiological pressure conditions. The greater the rupture pressure of complete cerebral arteries, the smaller the contribution of adventitia in overall wall resistance.

Keywords

Adventitia arterial pressure cerebrovascular diseases cerebral hemorrhage arterial wall mechanics ex vivo experiment

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