Synthesis of Triethyl N -Formyl- N -phosphonomethylglycinate and Diethyl N -Formyl- N -phosphonomethylglycine and Studies of Their Rotational Conformers by Dynamic NMR
Free accessResearch articleFirst published online February, 1999
Synthesis of Triethyl N -Formyl- N -phosphonomethylglycinate and Diethyl N -Formyl- N -phosphonomethylglycine and Studies of Their Rotational Conformers by Dynamic NMR
Reaction of ethyl N-phosphonomethylglycinate with triethyl orthoformate gave a mixture of triethyl N-formyl-N-phosphonomthylglycinate (3) and diethyl N-formyl-N-phosphonomethylglycine (4), the rotational barriers of which have been investigated theoretically and experimentally.
References
1.
The Herbicide Glyphosate ed. GrossbardE., and AtkinsonD., Butterworth, London, 1985.
2.
(a) WibergK. B., RablenP. R., RushD. J., and KeithT. A., J. Am. Chem. Soc., 1995, 117, 4261; (b) R. C. Neuman, Jr. and V. Jonas, J. Org. Chem., 1974, 39, 925; (c) T. Ozawa, Y. Isoda, H. Watanabe H, Yuzuri T, Suezawa, K. Sakakibara and M. Hirota, Magn. Resort. Chem., 1997, 35, 323.
