Drugs Causing Diarrhoea and Antidiarrhoeals in the Intensive Care Unit (ICU)

Kelly TWJ Patrick MR Hillman KM Study of diarrhoea in critically ill patients. Crit Care Med 1983; 11: 7–9.

Wiesen P Van Gossum A Preiser J-C . Diarrhoea in the critically ill. Current Opinion in Critical Care, 2006; 12: 149–54.

Lewis SJ Heaton KW . Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 1997; 32: 920–4.

Keohane PP Attrill H Jones BJM Roles of lactose and clostridium difficile in the pathogenesis of enteral feeding associated diarrhoea. Clin Nutr 1983; 259: 119–122.

Rubin MS Bodenstein LE Kent CE . Severe Clostridium difficile colitis. Dis Col Rectum 1995; 38: 350–354.

Bartlett JG . Clostridium difficile: old and new observations. Clin Gastroent. 2007; 1: 124–5.

Bartlett JG . Clinical Practice: Antibiotic associated diarrhoea. N Engl J Med 2002; 346: 334–39.

Cataldi-Betcher EL Seltzer MH Slocum BA Complications occurring during enteral nutritional support: A prospective study. J Paren Ent Nutr 1983; 7: 546–52.

Keohane PP Attrill H Love M Relation between osmolality of diet and gastrointestinal side effects of enteral nutrition. Br Med J 1984; 288: 678–80.

Randall HT . Enteral nutrition: tube feeding in acute and chronic illness. J Paren Ent Nutr 1984; 8: 113–136.

Whelan K Judd PA Taylor MA . Defining and reporting diarrhoea during enteral tube feeding. Do health professionals agree? J Hum Nutr Diet 2003; 16: 21–26.

Victora CG Bryce J Fontaine O Reducing deaths from diarrhoea through oral rehydration therapy Bull World Health Organ 2000; 78. doi: 10.1590/S0042-96862000001000010, accessed 25/10/07.

British National Formulary. bnf. org 9.2.1 Oral preparations for fluid and electrolyte imbalance.

Whelan K Gibson GR Judd PA The role of probiotics and prebiotics in the management of diarrhoea associated with enteral tube feeding. J Hum Nutr Diet 2001; 14: 423.

Cremonini F Di Caro S Nista EC Meta-analysis: the effect of probiotic administration on antibiotic-associated diarrhoea. Alimnet Pharmacol Ther 2002; 16: 1461–7.

D'Souza AL Rajkumar C Cooke J Probiotics in the prevention of antibiotic associated diarrhoea: Meta-analysis. BMJ 2002: 324: 1361.

Dendukuri N Costa V McGregor M Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhoea: a systematic review. CMAJ 2005; 173: 367.

Fekety R Silva J Kauffman C Treatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: comparison of two dosage regimens. Am J Med 1989; 86: 15,396–402.

Teasley DG Olson MM Gebhard RL Prospective, randomised trial of metronidazole versus vancomycin for clostridium difficile associated diarrhoea and colitis. Lancet 1983; 2: 1043–6.

Lagrotteria D Holmes S Smieja M Prospective, Randomised Inpatient Study of Oral Metronidazole versus Oral Metronidazole and Rifampin for Treatment of Primary Episode of Clostridium difficile Associated Diarrhea. Clin Infect Dis 2006; 43: 547–552.

Bricker E Garg A Nelson R Antibiotic treatment for clostridium difficile associated diarrhoea in adults. Cochrane data base systematic review 2005: CD004610.

Jodlowski TZ Oehler R Kam LW emerging therapies for Clostidium difficile associated disease. Ann Pharmacother 2006; 40: 2164–9.

Fox LM Saravolatz LD . Nitazoxanide: a new thiazolide antiparasitic agent. Clin Infect Dis 2005; 40: 1173–80.

Musher DM Logan N Hamill RJ Nitazoxanide for the treatment of Clostridium difficile colitis. Clinc Inf Dis 2006; 43: 421–33.

Louie TJ Peppe J Watt CK Tolevamer, a novel non-antibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile associated diarrhoea. Clin Inf Dis 2006; 43: 411–420.