Nosocomial COVID-19,a risk illustrated by the first in-hospital transmission of B.1.1.7 variant of SARS-CoV-2 in a French University Hospital

Abstract

Objectives

In this short report, we describe the first nosocomial spread of B.1.1.7 variant (GR/20I/501Y.V1) in a French hospital, underlining the different aspects of in-hospital transmission of SARS-CoV-2.

Patients and methods

Retrospective study of a SARS-CoV-2 cluster investigation in January 2021. All cases were screened with RT-PCR.

Results

First transmission occurred in a double room with a COVID-19 imported cases, undetected upon admission. Healthcare workers, their relatives and patients’ relatives were screened. Eleven secondary cases were identified within a week, in and out of the hospital (in hospital attack rate: 3.1%). No severe COVID-19 was encountered.

Conclusions

This report highlights several in-hospital chains of transmission involved with COVID-19 with rapid spread.

Keywords

Nosocomial COVID-19 outbreak SARS-CoV-2 infection control

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References

Abbas

Robalo Nunes

Martischang

, et al. (2021) Nosocomial transmission and outbreaks of coronavirus disease 2019: the need to protect both patients and healthcare workers. Antimicrobial Resistance and Infection Control 10(1): 7.

Gordon

Trubiano

Holmes

, et al. (2021) Staff to staff transmission as a driver of healthcare worker infections with COVID-19. Infection, Disease and Health 26(4): 276–283.

Kampf

Brüggemann

Kaba

HEJ

, et al. (2020) Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2. Journal of Hospital Infection 106(4): 678–697.

Klompas

Baker

Rhee

, et al. (2021) A SARS-CoV-2 cluster in an acute care hospital. Annals of Internal Medicine 174(6): 794–802.

Lepelletier

Grandbastien

Romano-Bertrand

, et al. (2020) French society for hospital hygiene and the high council for public health what face mask for what use in the context of COVID-19 pandemic? The French guidelines. Journal of Hospital Infection 105(3): 414–418.

Picard

Cornec

Baron

, et al. (2020) Wearing of face masks by healthcare workers during COVID-19 lockdown: what did the public observe through the French media? Journal of Hospital Infection 106(3): 617–620.

Ponsford

Ward

TJC

Stoneham

, et al. (2021) A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults. Frontiers in Immunology 12: 744696.

Santé Publique France . (2021) Enquêtes flash : évaluation de la circulation des variants du SARS-CoV-2 en France. Available at: https://www.santepubliquefrance.fr/etudes-et-enquetes/enquetes-flash-evaluation-de-la-circulation-des-variants-du-sars-cov-2-en-france (accessed 28 October 2021).

Santé Publique France . (2022) Signalement d’infections à SARS-CoV-2 nosocomiales/Point au 20 janvier 2022. https://www.santepubliquefrance.fr/maladies-et-traumatismes/maladies-et-infections-respiratoires/infection-a-coronavirus/documents/enquetes-etudes/signalement-d-infections-a-sars-cov-2-nosocomiales.-mars-2020-janvier-2022.-point-au-20-janvier-2022 (accessed 20 February 2022).