Salvage surgery for recurrent or persistent tumour after radical (chemo)radiotherapy for locally advanced non-small cell lung cancer: a systematic review

Abstract

Background:

Once recurrent or persistent locoregional tumour after radical chemoradiotherapy (CRT) for non-small cell lung cancer (NSCLC) is identified, few curative-intent treatment options are available. Selected patients might benefit from surgical salvage. We performed a systematic review of the available literature for this emerging treatment option.

Methods:

A systematic literature search was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Publications about persistent or (locoregional) recurrent disease after radical/definitive CRT for locally advanced non-small cell lung cancer were identified.

Results:

Eight full papers were found, representing 158 patients. All were retrospective series and data were heterogeneous: definition and indication for salvage surgery varied and the median time from radiotherapy to surgery was 4.1–33 months. Complete resection (R0) was achieved in 85–100%, with vital tumour in 61–100%. A large number of pneumonectomies were performed, and additional structures were often resected. Where reported, 90-day mortality was 0–11.4%. Reported survival metrics varied but included median overall survival 9–46 months and 5-year survival 20–75%.

Conclusion:

There are limited, low-level, heterogeneous data in support of salvage surgery after radical CRT. Based on this, perioperative mortality appears acceptable and long-term survival is possible in (highly) selected patients. In suitable patients (fit, no distant metastases, tumour appears completely resectable and preferably with confirmed viable tumour), this treatment option should be discussed in an experienced multidisciplinary lung cancer team.

Keywords

chemoradiotherapy non-small cell lung cancer (NSCLC)recurrence salvage surgery

Introduction

The guideline-recommended, curative-intent (radical) treatment for fit patients with locally advanced (stage III) non-small cell lung cancer (NSCLC) is high-dose (typically equivalent to ⩾60 Gy in 2 Gy/fraction) concurrent chemoradiotherapy (CRT).¹ Although this is increasingly being used,² failure of this strategy is not uncommon, with a 2-year reported incidence of locoregional and distant failure after 60 Gy of 30.7% and 46.6%, respectively.³ Once recurrent or persistent locoregional tumour after radical CRT is identified, a second attempt at radical treatment may be possible in selected patients. For example, fit patients with isolated local failure in the previous irradiated high-dose volume, might be candidates for surgical ‘salvage’ and removal of vital tumour. However, such surgery can be technically more challenging and associated with increased risks, particularly when central/hilar structures have been irradiated and centrally located surgery is needed. Not all surgical teams may have experience of operating in these situations. For such reasons, we suspect that salvage surgery is not always considered in all multidisciplinary tumour boards. In this report, we have systematically collected and reviewed the available literature regarding salvage surgery for the treatment of locoregional failure after curative-intent (or definitive, or radical) CRT. These data could be used to aid decision making during multidisciplinary tumour board discussions and to inform shared decision making with patients. Greater awareness of salvage options is likely to increase demand for this treatment.

Methods

Study selection

A literature search was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.⁴ Publications about persistent or (locoregional) recurrent NSCLC following curative-intent CRT were identified in the bibliographic databases PubMed (Appendix 1, Supplementary Table 1), Embase (Appendix 1, Supplementary Table 2), and the Cochrane Library (via Wiley) (Appendix 1, Supplementary Table 3), from inception to 21 February 2018. Search terms included controlled terms (MeSH in PubMed and Emtree in Embase) as well as free text terms. We used free text terms only in the Cochrane Library. Search terms expressing ‘non-small cell lung cancer’ were used in combination with ‘chemoradiotherapy’ and ‘recurrence’. Only full-length English-language papers were included in the review.

All articles were initially screened by title and then by abstract to progressively exclude nonrelevant reports. The articles selected on the basis of their abstract were accessed in full and further screened. Finally, the reference lists of relevant articles, reviews, and editorials were searched. Articles meeting the following criteria were included in this systematic review: any type of original full-length English-language report concerning surgery for locoregional recurrence or persistent tumour after any form of radical CRT for NSCLC. Debate over article selection was resolved by consensus. All final studies were independently reviewed by two authors to extract relevant information, including article type, number of patients, radiotherapy details, time between radiotherapy and surgery, type of surgery, morbidity, mortality, follow up and survival.

Data analysis

A quantitative data analysis (meta-analysis) was planned; however, the reported data were not sufficiently homogeneous for this (with respect to parameters such as time of follow up, morbidity and overall survival). In addition, due to the small sample sizes and heterogeneity in the aforementioned study characteristics, pooling of data was not appropriate. Therefore, we performed a qualitative overview of the current publications and summarized the most important outcome measures.

Results

Search results

Figure 1 depicts the results of our search strategy (see also Appendix 1). The initial search resulted in 2456 relevant records: 747 from PubMed, 1643 extracted from Embase and 67 from the Cochrane Library. After screening of all titles, 53 abstracts were identified for further screening. An additional 22 records were excluded during this phase, resulting in 31 reports for full text evaluation. Conference abstracts or poster presentations (n = 15), duplicate papers (n = 7), papers with duplicate patients (same author and inclusion period) (n = 1), and non-English-language papers (n = 1), were excluded. Cross checking references from selected papers identified two additional references, of which one was included in the final analysis. At the end of this process, a total of eight full papers were available for this systematic review (Table 1), representing 158 patients.

Figure 1.

Flowchart depicting study selection according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.

Table 1.

Summary of studies included in the qualitative analysis.

Author	Article type	Inclusion period (years)	n	CTx	Median RT dose(Gy)	Median time RT-Sx (months)^*	PA proven pre-Sx	Typeresection	Additionalresection	Stump coverage	Medianblood loss(ml)	Duration Sx (median, h)	Median hospital stay (days)	R0/R1	Viable tumour on pathology
Baumann et al. 2008⁵	Retro	1997–2005 (9)	24	22/24 Pt, Cc	63.9 (59.4–70.2)	4.75 (1.2–21.6)	Not mandatory	P 10, BL 4, L 10, W 1	CW 5, PA 1	76% (19/25)	250 (0–4400, for 22/35 resections)	5.5 (2.2–9.4)	8 (4–46)	23/2	79% (19/24)
Kuzmik et al. 2013⁶	Retro	June 2006–August 2012 (6.3)	14	12/14 Pt, Cc	57 (30–74)	33 (0–169)	14/14	P 2, L 9 (1 sleeve), S 2, W1	CW 3	36% (5/14)	n.r.	n.r.	10	14/0	100% (14/14)
Yang et al. 2015⁷	Retro	January 1995–November 2012 (17.9)	31	29/31 Pt, Cc	60 (40–>70)	4.1 (1.8–25.7)	Not mandatory	BL 1, L 30 (6 VATS)	CW 5, PA+PV 1	35% (11/31)	n.r.	n.r.	4 (2–18)	30/1	61% (19/31)
Dickhoff et al. 2016⁸	Retro	January 2007–August 2015 (8.7)	15	12/15 Pt, Cc 3/15 Pt, Sq	66 (60–70)	21 (3–95)	9/15	P 8, BL 2, L 4, S 1	CW 1	100% (15/15)	n.r.	3.75 (2.1–6.45)	7 (5–12)	13/2	100% (15/15)
Shimada et al. 2016⁹	Retro	January 2004–November 2013 (9.9)	18	18/18 Pt, Cc	60 (60–74)	8.8 (0.7–65.1)	Not mandatory	P 5 (1 sleeve), BL 1, L 12	CW 3, SVC 2, SA 1, Vert 1	78% (14/18)	399 (5–2140)	5 (1.97– 11.8)	11 (5–20)	16/2	50% (9/18) (64%, 9/14 evaluable patients)
Sawada et al. 2015¹⁰	Retro	2005–2014 (10)	8	8/8 Pt	n.r.	9.4 (3–50)	n.r.	P 1, L 7	PA 2, Br-plasty 2	n.r.	n.r.	n.r.	n.r.	8/0	100% (8/8)
Casiraghi et al. 2017 ¹¹	Retro	June 2003–June 2013 (10)	35	32/35 Pt (3+ cycles)	Mean 58 (45–75)	7 (1–39)	26% (9/35)	No resection 6, P 17, BL 1, L 11	CW 2, SVC 2, Tracheal sleeve 1, Va Sl 1, Br Sl 1, Atrium 1	62% (18/29)	n.r.	n.r.	7 (4–45)	27/2	89.6% (26/29) (6/35 explored only – no resection)
Schreiner et al. 2018 ¹²	Retro	March 2011–November 2016 (5.8)	13	13/13 Pt	66 (59.4– 72)	6.7 (2.9–38.5)^**	n.r.	P 1, BL 2, L 6, Bi-S 3, W1	CW 7, Vert 2, Aortic arch 1, SA 1, Pl Br 2	46% (6/13)	n.r.	3.9 (1.9–8.4)	17 (8–68)	11 /2	92.3% (11 primary tumour, 1 LN only)

Where reported in weeks, it was calculated in months: months = weeks/4.33.

Values from Results section text, different data presented in Table 2.

Bi-S, bisegmentectomy; BL, bilobectomy; Br-plasty, bronchoplasty; Br Sl, bronchial sleeve; Cc, concurrent; CRT, chemoradiotherapy; CTx, chemotherapy; CW, chest wall; DFS, disease-free survival; L, lobectomy; LN, lymph node; n.r., not reported; P, pneumonectomy; PA, pulmonary artery; Pl Br, plexus brachialis; Pt, (carbo-/cis-/neda-) platinum-based CTx; PV, pulmonary vein; Retro, retrospective series; RT, radiotherapy; S, segmentectomy; SA, subclavian artery; Sq, sequential; SVC, superior vena cava; Sx, surgery; Va Sl, vascular sleeve; VATS, video-assisted thoracic surgery; Vert, vertebral resection; W, wedge.

Study characteristics

All selected articles were retrospective series, published during the previous decade (2008–2018). The articles included 158 patients,^5–12 and the first reported patient was operated on in 1995.⁷ However, not all of these patients had full-dose (C)RT^6,7,11 or local tumour recurrence within the previous radiotherapy volume,^5,6 and some reports included patients that were operated within 3 months of the last day of radiotherapy,^5,7,9,11 reflecting the wide variety of definitions and indications for salvage surgery used in the literature (Table 2). In addition, there was heterogeneity in definition and inclusion of other parameters, including: when the reported age was measured (Table 3); comorbidity and physical fitness (e.g. not reported^10,11); performance status (PS);⁹ forced expiratory volume at 1 s (FEV₁);⁵ or Charlson Comorbidity Index.⁸ The majority of patients were male and relatively young (Table 3).

Table 2.

Definitions and indications for salvage surgery.

Author	Definition of salvage	Indication for salvage and comments
Baumann et al. ⁵	Prior treatment of NSCLC, cytology or histology proven, with curative-intent RTx (>59 Gy) ± CTx No a priori plan for trimodality incorporating surgical resection Salvage wedge, lobectomy or pneumonectomy	Interval growth of primary tumour on thoracic CT imaging (n = 7) Hypermetabolic abnormality on FDG-PET (4–26 weeks after RTx) in primary tumour or locoregional lymph nodes (n = 13) Empiric conversion to trimodality therapy after surgery had been inappropriately excluded (n = 4) Chronic bronchopleural fistula (n = 1) No routine tissue confirmation due to ‘poor sensitivity and negative-predictive value’ after CRTx
Kuzmik et al. ⁶	Prior treatment of lung cancer with curative-intent RTx ± concurrent CTx Surgical resection for recurrent disease at any point and location N2 disease excluded	Recurrence detected by PET scan (54%) or CT scan (46%) All had histopathological confirmation recurrence Local = 54%; separate ipsilateral lobe = 15%; contralateral lobe = 31%
Yang et al. ⁷	Prior treatment of NSCLC, biopsy proven, with curative-intent RTx, ± CTx No a priori plan for eventual surgical resection Salvage lobectomy after multidisciplinary evaluation	No metabolic activity at the primary after RTx with subsequent increased FDG activity CT or PET suggestive of residual disease in primary or locoregional nodes Patient initially considered medically inoperable then became medically operable No routine preoperative tissue confirmation for same reason as Baumann Multidisciplinary discussion Preoperative CT and FDG-PET/CT Brain MRI/CT in 17/31
Dickhoff et al. ⁸	Pulmonary resection for locoregional recurrence or persistent tumour in the irradiated area, ⩾12 weeks after radical CRTx (⩾60 Gy) for the treatment of NSCLC	CT and FDG-PET/CT suspicion of recurrence or persistent disease Tissue confirmation attempted in 11/15 and positive in 9 Preoperative FDG-PET/CT in all patients, 13/15 had preoperative MRI or CT brain Multidisciplinary discussion
Shimada et al. ⁹	Prior treatment of stage III NSCLC, cytology or histology proven, with curative-intent chemoradiotherapy (⩾60 Gy) No a priori plan for multimodality therapy incorporating surgery Confirmation of locoregional recurrence or persistent tumour in the previously irradiated area	Persistent disease (n = 8) Primary tumour had regrown (n = 10)
Sawada et al. ¹⁰	Patients with pathologically proven N2 stage-IIIA NSCLC treated with definitive CRTx Subsequent pulmonary resection with curative intent for residual disease (good response to CRTx, but small volume residual tumour at 1–2 sites) or isolated locoregional recurrence (after initial complete response to CRTx)	Residual disease (n = 4) Locoregional recurrence (n = 4) Multidisciplinary evaluation (including pulmonary function)
Casiraghi et al. ¹¹	Histologic or cytologic diagnosis of NSCLC before the original CRTx treatment Initial CRTx with curative intent and no planned surgery in their treatment approach Patients receiving <59 Gy RTx due to toxicity but with >12-week interval before surgery included Patients receiving >59 Gy RTx and surgery <8 weeks after CRTx included Local ipsilateral persistent disease (no regression) or recurrence (complete response followed by new lesions) following CRTx Tumour considered completely resectable	Staging FDG-PET/CT in all Multidisciplinary discussion Confirmation tumour was attempted in 20/35 (9 positive)
Schreiner et al. ¹²	Pulmonary resection for local recurrence or residual lung tumour after definitive CRTx for locally advanced NSCLC	Residual tumour (n = 6) Local recurrence (n = 7) Preoperative CT, FDG-PET/CT, brain MRI, lung function

CT, computed tomography; CRTx, chemoradiotherapy; CTx, chemotherapy; FDG, fluorodeoxyglucose; MRI, magnetic resonance imaging; NSCLC, non-small cell lung cancer; PET, positron-emission tomography; RTx, radiotherapy.

Table 3.

Postoperative survival and recurrence data.

Author	Year/patients (M/F; age)	Median follow-up duration (months)	PFS post Sx (median, months)	Site of recurrence	OS post Sx (median, months)
Baumann et al. ⁵	2008/24 (12/12; median = 60^*)	n.r. (29 months for 10 survivors)	12	DP 6, LF 2, LF + DP 3	30 3 years 47%
Kuzmik et al. ⁶	2013/14 (6/8; median = 64 at Sx)	n.r.	n.r.	n.r.	9 2 years 49%
Yang et al. ⁷	2015/31 (18/13; median = 58 at Sx)	26 (40 months for survivors)	3 years 30% 5 years 23%	DP 7, LRF 4, LF + DP 2	32.5 3 years 42% 5 years 31%
Dickhoff et al. ⁸	2016/15 (11/4; median = 59 at CRTx)	12.1	43.6 (EFS)	DP 2, LF + DP 1	46
Shimada et al. ⁹	2016/18 (17/1; 63 at CRTx^*)	46.2	3 years 72%	DP 2, LRF 3, LRF + DP 1	3 years 78%
Sawada et al. ¹⁰	2015/8 (8/0; median = 61^*)	48	n.r.	RF 1	5 years 75%
Casiraghi et al. ¹¹	2017/35 (27/8; <60 n = 14, 60–69 n = 14, ⩾70 n = 7^*)	13	12 3 years 20% 5 years 20%	n.r.	13 3 years 32% 5 years 20%
Schreiner et al. ¹²	2018/13 (8/5; median = 56 at Sx)	50.4	21.9 5 years 44%	DP 5, LRF 5	29.7 3 years 46% 5 years 46%

Timepoint or mean/median specifically mentioned.

CRTx, chemoradiotherapy; DP, distant progression; EFS, event free survival; LF, local failure; LRF, locoregional failure; M/F, male/female; n.r., not reported; OS, overall survival; PFS, progression-free survival; RF, regional failure; Sx, surgery.

Primary treatment

The median radiotherapy dose during primary treatment varied from 57 to 66 Gy in six studies,^5–9,12 with one study reporting the mean (58 Gy)¹¹ and one not reporting either.¹⁰ The majority of patients received concurrent, carbo-/cisplatinum-based chemotherapy (Table 1).

The median time from radiotherapy to surgery varied between 4.1 and 33 months. Confirmation of vital tumour before surgery was not attempted in all studies (Table 2), and many patients were selected for surgery based on the suspicion of local recurrence or persistent tumour on imaging [e.g. computed tomography (CT) scan or fluorodeoxyglucose positron-emission tomography (FDG-PET) scan].

Preoperative mediastinal nodal involvement

In 7/8 of the studies, suspected mediastinal lymph involvement was not considered a reason to exclude patients from salvage surgery.^5,7–12 Several authors reported that they performed mediastinoscopy and provided some numerical data: Casiraghi and colleagues performed the procedure in 20/35 (57%) patients and did not specifically describe any related complications;¹¹ Yang and colleagues performed mediastinoscopy ‘along with lobectomy’ in 15/31 patients (48%), with no specific mention of complications.⁷ They had one patient with mediastinal nodal involvement (N2) in their series; this was station five, which had not been evaluated by preoperative mediastinoscopy; Baumann and colleagues performed mediastinoscopy in 19/24 (79%) patients (including one repeat) and described a patient who needed aortic arch replacement following injury during mediastinoscopy.⁵

Salvage surgery

For patients undergoing resection (n = 152), a total of 44 pneumonectomies, 11 bilobectomies, 89 lobectomies, 6 segmentectomies and 3 wedge resections were performed. In one study,⁵ the same patient was operated on twice (initial lobectomy and then completion pneumonectomy 20 months later for a second local recurrence). Additional resections consisted of chest wall (n = 22), pulmonary artery (n = 4), bronchial sleeve or plasty (n = 4), superior vena cava (n = 3), subclavian artery (n = 2), tracheal sleeve (n = 1), brachial plexus (n = 2), aorta (n = 1) and vertebral resection (n = 1). The rate of bronchial stump coverage with a vascularized muscle flap, pericardial transposition or omentum varied between 35% and 100% and was not reported in one article.¹⁰ Four studies reported median duration of surgery, which was between 3.75–5.5 h, median estimated blood loss of 250 ml and 399 ml was reported in two articles, median length of hospital stay was reported in seven articles, varying between 4–17 days (the range was reported in six, varying from 24 to 68 days) (Table 1).

One study reported six patients in whom intraoperative decision making resulted in no resection,¹¹ and one study did not mention resection margin.⁶ Leaving these patients out, the proportion of R0 (complete microscopic) resections was 85–100%. Vital tumour was reported in all studies and ranged between 61% and 100% of patients. Where reported, mediastinal lymph node dissection was performed in a varying number of patients; 14/24 (58%);⁵ ‘routinely performed’;⁷ all patients had lymph nodes resected but number of stations varied between one and eight (median four);⁸ 18/18 (100%) with varying extent;⁹ 8/8 (100%)¹⁰ based on pN staging reported for all patients; ‘all patients’ underwent radical lymphadenectomy with systematic node dissection;¹¹ ‘all lung resections were followed by systematic hilar and mediastinal lymph node dissection’.¹² Where reported, the incidence of pathologically confirmed N2 disease in the resection specimen was 3,⁷ 8,¹² 13,⁸ 21⁵ and 50%.¹⁰ In addition, some patients who had stage IV disease prior to CRT or salvage surgery were included: the incidence was 3,¹¹ 8,⁵ 8,¹² 13⁷ and 14%.⁶ There were two patients in one study who had adjuvant chemotherapy for N2 disease found on pathological examination of the resected specimen.¹⁰

Morbidity, mortality and survival

All studies reported perioperative morbidity and mortality in some way (Table 4): the median reported morbidity ranged from 28% to 58% and perioperative mortality varied between 0% in four studies,^6,7,9,10 up to 11.4% (4/35 patients) at 90 days.¹¹ In each of the remaining three studies, one patient died perioperatively.^5,8,12 Overall survival (OS) and the recurrence pattern are presented in Table 3. OS was reported in all studies and progression-free survival (PFS) in 6/8 studies. As previously mentioned in the Methods section, pooling OS and PFS data was not appropriate. Except for one study,¹⁰ distant metastases were the most frequent primary cause of progression. None of the articles included quality of life/patient-reported outcome measures.

Table 4.

Details of perioperative morbidity and mortality after salvage surgery.

Author	Morbidity	Details morbidity	Perioperative mortality	Details mortality
Baumann et al. ⁵	58% (at least one complication in 14/24 patients, including 1 death; >1 complication in 8/24)	Major: ARDS (n = 1), chylothorax (n = 1), major vessel injury (n = 2), infarction/ventricular fibrillation arrest (n = 1), pneumonia (n = 4) prolonged intubation requiring tracheostomy (n = 2), renal failure (n = 1), splenic injury requiring splenectomy (n = 1) Minor: prolonged gastric ileus (n = 1), stump dehiscence (spontaneously closed) (n = 1), transient supraventricular tachycardia (n = 7), vocal cord palsy (n = 4)	4% (1/24)	Postpneumonectomy ARDS and multi-organ failure (n = 1)
Kuzmik et al. ⁶	43% (6/14; 83% CTCAE GIII/IV)	High-grade (CTCAE GIII/V): recurrent laryngeal nerve paralysis, pneumonia, bronchopleural fistula, ARDS, respiratory compromise Other (CTCAE GII): urinary tract infection	90 days 0%
Yang et al. ⁷	48% (at least one complication in 15/31; >1 complication in 2; major complications in 5)	Major: primary repair pulmonary artery/vein with postoperative atrial fibrillation (n = 1), postoperative hemothorax requiring re-thoracotomy (n = 1), pneumonia (n = 3)Other: postoperative bleeding requiring transfusion (n = 3), pneumonia (n = 1), atrial fibrillation (n = 3), prolonged air leak (n = 3)	0%
Dickhoff et al. ⁸	40% (6/15)	Herniation heart (n = 1)^,, pneumonia (n = 1), fever of unknown origin (n = 2), atrial flutter (n = 1), empyema^	90 days 6.7% (1/15)	ARDS (n = 1)
Shimada et al. ⁹	28% (5/18)	Pneumonia (n = 2), arrhythmia (n = 2), chylothorax and delayed pulmonary fistula (n = 1)	90 days 0%
Sawada et al. ¹⁰	38%(3/8)	Chylothorax (n = 1), pneumonia and recurrent laryngeal nerve palsy (n = 1), pleural effusion (n = 1)	0%
Casiraghi et al. ¹¹	25.7% major (9/35); 25.7% minor	Major: bronchopleural fistula (n = 2)^$, bronchovascular fistula (n = 2), pneumonia or ARDS (n = 2), chylothorax (n = 1), stroke (n = 1), heart failure (n = 1)Minor: atrial fibrillation (n = 7), anaemia (n = 5), atelectasis (n = 4), air leak (n = 3)	30/90 days 5.7/11.4% (2/4 out of 35)	Bronchovascular fistula with massive haemoptysis (n = 2), not further explained (n = 2)
Schreiner et al. ¹²	38% (5/13)	Revision infected wound (n = 2), post-resection empyema and ARDS (n = 1), revision unstable osteosynthetic material after vertebral stabilization (n = 2)	30-day 7.7% (1/13)	Multiple organ failure after pneumonectomy and partial aortic arch resection (n = 1)

Requiring rethoracotomy.

This patient subsequently died.

One treated with direct suture and flap cover, one with thoracostomy after 2 months.

ARDS, adult respiratory distress syndrome; CTCAE, common terminology criteria for adverse event; G, grade.

Discussion

To the best of our knowledge, this is the first systematic review of the literature concerning salvage surgery for recurrent or persistent NSCLC after high-dose (C)RT. We identified eight eligible full-length English-language papers, all of which described retrospective series, representing a total of 158 patients. They show that salvage surgery consisting of anatomical lung resection and mediastinal lymph node dissection is feasible, that it can be performed with an acceptable mortality rate (comparable with planned trimodality protocols) despite frequent major resections involving additional organs, and that it can deliver promising clinical outcomes.^13,14 However, the 158 patients were accumulated over a combined total of 77.6 years (Table 1), and with a locoregional failure rate after CRT of around 30% at 2 years;³ this indicates that, until now, a tiny proportion of such patients has received salvage surgery. This means that the patients in these eight studies have to be considered highly selected (e.g. young, fit, limited tumour burden with high a priori chance of complete R0 resection). In addition, the type of studies (retrospective case series) represent a low level (level 4) of evidence according the Oxford Centre for Evidence-Based Medicine.¹⁵ Combined with the heterogeneity of the series, including with respect to inclusion criteria, definition of salvage surgery (some included post-CRT complications, elective conversion to trimodality strategy and contralateral tumours^5,6), indications for operation and follow up, this precludes drawing definitive conclusions and the data have to be interpreted with caution.

When locoregional failure after radical-intent CRT for locally advanced NSCLC occurs, treatment frequently focuses on palliative or supportive care. However, chemotherapy in patients previously treated with platinum-based CRT has been reported to have a response rate as low as 10%,¹⁶ and the role of immunotherapy or targeted therapy in this clinical setting still requires investigation. In a small number of patients, high-dose re-irradiation is an option, and in highly selected patients (in particular those with smaller, noncentral tumours), reported survival (median approximately 13–15 months) is comparable with two of the salvage surgery studies included here.^6,11,17,18 However, it has to be noted that in the series from Casiraghi and colleagues, the OS data included six patients who underwent exploration only and that OS was median 27 months after R0 resection compared with 9 months after microscopic irradical resection (R1) or exploration.¹¹

The role of mediastinal lymph node involvement in this clinical scenario is unclear. Five of the eight studies had patients with postoperative N2 disease. This was as high as 50% (4/8) patients in the study of Sawada and colleagues,¹⁰ in which long-term survival was still observed. The data suggest that at the present time, N2 disease is not an absolute contraindication to salvage surgery. However, the disease should be technically completely resectable with acceptable risks. It is important to consider how aggressively the mediastinum should be staged prior to salvage surgery. There is evidence for the safety of mediastinoscopy after induction treatment in therapy-naïve patients;¹⁹ however, it cannot be assumed that this is also true for invasive diagnostics (mediastinoscopy/mediastinotomy) performed ⩾3 months after high-dose radiotherapy. There was at least one serious complication reported in this analysis and one case of N2 disease missed despite invasive staging. With a reported sensitivity of 67% and specificity of 99% for endosonographic procedures in mediastinal restaging of stage III lung cancer after neoadjuvant therapy (although predominantly induction chemotherapy), and no complications in 574 patients,²⁰ routine mediastinoscopy or mediastinotomy might be omitted before salvage surgery in favour of imaging (including FDG-PET/CT) and endosonographic staging.

Although there have been several reports on the feasibility and safety of planned surgery (trimodality therapy), including pneumonectomy after high-dose CRT in locally advanced NSCLC,^21,22 salvage surgery performed a considerable period of time after CRT is a relatively new treatment strategy for patients with recurrent or persistent tumour: all the papers that we identified were published during the last decade and only contain a total of 158 patients. If salvage surgery is being considered, patients should be referred to a sufficiently experienced team that is achieving acceptable outcomes and capable of managing the morbidity that can occur after salvage surgery (although we acknowledge that ‘sufficiently experienced’ and ‘acceptable outcomes’ have yet to be defined). If surgery after neoadjuvant chemotherapy or CRT is used as a benchmark for perioperative mortality, then the data reported here compare reasonably favourably with the 30- and 90-day mortality of 3% and 6.5%, respectively, reported in a National Cancer Database analysis.²³ Specialist teams performing salvage surgery are encouraged to report their results and national lung cancer surgery registries should also capture salvage activity and outcomes.

In our own practice, we define salvage surgery as resection for, preferably confirmed, recurrent/persistent disease in the irradiated volume, at least 12 weeks after completion of (C)RT.⁸ All potentially eligible patients are discussed within an experienced multidisciplinary lung cancer team and surgery is only considered if there is a realistic possibility of R0 resection and if the risks are considered acceptable. The average age of patients receiving salvage surgery is comparable with that of patients treated with elective trimodality therapy in our institution.^8–14 Patients should be adequately staged, including a contrast-enhanced CT of the thorax and abdomen, whole-body fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT, and magnetic resonance imaging (MRI) of the brain. Bronchoscopy should be performed and where necessary (e.g. suspicion of N2 nodal disease), endobronchial/oesophageal ultrasound (EBUS/EUS) or mediastinoscopy should be performed to accurately identify the extent of disease. Pulmonary function and cardiopulmonary exercise testing, high-risk anaesthetic assessment and preoperative involvement of the physiotherapist and dietitian should all be considered to maximize patient condition and postsurgical outcomes.

Although the limited data presented in this systematic review suggest that salvage surgery can be performed with acceptable risks, the treatment paradigm for locally advanced NSCLC is already changing, with the recent publication of data from the phase III PACIFIC study.²⁴ As a result of this, eligible patients may receive consolidation durvalumab [antiprogrammed death ligand 1 (PD-L1) antibody] after CRT. The safety of salvage surgery after durvalumab has not been reported and the possibility of increased risks cannot currently be excluded. In a recent report by Forde and colleagues,²⁵ a short course of neoadjuvant anti-PD-L1 treatment using nivolumab was followed by surgery. Although the number of patients treated and the surgical details are limited, they do not specifically mention increased surgical complications. Nonetheless, vigilance is required when combining new medications of various classes for the first time with radical thoracic surgery in previously irradiated tissues. Caution is also appropriate when operating after radiation doses significantly higher than those reported in these papers, especially in central locations. How much the risk of fistula is reduced by buttressing the bronchial stump with a muscle flap or omentum, and whether this increases the safety of operating after very high doses of radiotherapy, is uncertain. Techniques to assess tissue viability after CRT may merit further investigation for identifying a high risk of complications like fistula and stump dehiscence.²⁶

Finally, reliable identification of local recurrence on follow-up CT and PET/CT imaging after CRT can be challenging and we therefore believe that an attempt should be made to obtain proof of tumour recurrence prior to exposing a patient to the risks of surgery. This is supported by the viable tumour rate of as low as 61% in the research of Yang and colleagues⁷ and 64% of evaluable patients in the study by Shimada and colleagues.⁹ In the future, the detection of circulating tumour cells or tumour DNA could facilitate early identification of residual or recurrent disease.^27,28 In addition, improved imaging techniques, such as PET/MRI, combined with functional tests, like diffusion-weighted imaging, could further improve detection of recurrent tumour and distinguish it from pseudoprogression or fibrotic changes after CRT.²⁹

Conclusion

There are limited, low-level, heterogeneous data in support of salvage surgery after radical CRT. Based on this, perioperative mortality appears acceptable, and long-term survival is possible in (highly) selected patients. In suitable patients (fit, no distant metastases, tumour appears completely resectable and preferably with confirmed viable tumour), this treatment option should be discussed within an experienced multidisciplinary lung cancer team.

Supplemental Material

Appendix_1 – Supplemental material for Salvage surgery for recurrent or persistent tumour after radical (chemo)radiotherapy for locally advanced non-small cell lung cancer: a systematic review

Supplemental material, Appendix_1 for Salvage surgery for recurrent or persistent tumour after radical (chemo)radiotherapy for locally advanced non-small cell lung cancer: a systematic review by Chris Dickhoff, Rene H. J. Otten, Martijn W. Heymans and Max Dahele in Therapeutic Advances in Medical Oncology

Footnotes

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflict of interest statement

MD has received research funding and honoraria/travel support from Varian Medical Systems (Palo Alto, California, USA).

Supplemental Material

Supplemental material for this article is available online.

ORCID iD

Chris Dickhoff

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