The association of intercellular adhesion molecule 1 (ICAM-1) genetic polymorphisms with uterine cervical carcinogenesis has seldom been reported. Therefore, the aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) and haplotypes of ICAM-1 with cervical tumorigenesis in Taiwanese women. Four hundred forty four women, including 91 with cervical invasive cancer, 63 with precancerous lesions, and 290 normal controls, were recruited. The genotypic distribution of 4 SNPs of ICAM-1, rs5498 (A1548G), rs5491 (K56M), rs281432 (C8823G), and rs3093030 (C-286T) was determined using real-time polymerase chain reactions and genotyping. Compared to homozygous wild CC, heterozygous CG, homozygous mutant GG, or genotypes with CG/GG display increased risks or a tendency of precancerous lesions or invasive cancer with strong power in rs281432. The homozygotic mutant alleles TT in rs3093030 and homozygotic mutant alleles GG in rs5498 were associated with a higher risk of invasive cancer and precancerous lesions, respectively, but with lower power. The CG/TA/TG haplotypes of ICAM-1 SNPs rs3093030 and rs5498 exhibited a tendency to increase susceptibility to precancerous lesions and invasive cancer. In conclusion, Taiwanese women with ICAM-1 SNP rs281432 and haplotypes CG/TA/TG of rs3093030 and rs5498 are associated with uterine cervical carcinogenesis.
NasiellKRogerVNasiellM. Behavior of mild cervical dysplasia during long-term follow-up. Obstet Gynecol. 1986;67(5):665–669.
2.
van de StolpeAvan der SaagPT. Intercellular adhesion molecule-1. J Mol Med. 1996;74(1):13–33.
3.
HopkinsAMBairdAWNusratA. ICAM-1: targeted docking for exogenous as well as endogenous ligands. Adv Drug Deliv Rev. 2004;56(6):763–778.
4.
DietrichJB. The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier. J Neuroimmunol. 2002;128(1-2):58–68.
5.
LeeEBKimJYKimEHNamJHParkKSSongYW. Intercellular adhesion molecule-1 polymorphisms in Korean patients with rheumatoid arthritis. Tissue Antigens. 2004;64(4):473–477.
LawsonCWolfS. ICAM-1 signaling in endothelial cells. Pharmacol Rep. 2009;61(1):22–32.
8.
TsakadzeNLZhaoZD’SouzaSE. Interactions of intercellular adhesion molecule-1 with fibrinogen. Trends Cardiovasc Med. 2002;12(3):101–108.
9.
IwaoMMorisakiHMorisakiT. Single-nucleotide polymorphism g.1548G > A (E469K) in human ICAM-1 gene affects mRNA splicing pattern and TPA-induced apoptosis. Biochem Biophys Res Commun. 2004;317(3):729–735.
10.
ChenHHernandezWShriverMDChenHHernandezWShriverMD. ICAM gene cluster SNPs and prostate cancer risk in African Americans. Hum Genet. 2006;120(1):69–76.
11.
TianMMSunYLiZWWuYZhaoALLiJY. Polymorphisms of ICAM-1 are associated with gastric cancer risk and prognosis. World J Gastroenterol. 2012;18(4):368–374.
12.
KammererSRothRBRenelandR. Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus. Cancer Res. 2004;64(24):8906–8910.
13.
PetignatPRoyM. Diagnosis and management of cervical cancer. BMJ. 2007;335(7623):765–768.
14.
LinYSLiuYFChouYE. Correlation of chitinase 3-like 1 single nucleotide polymorphisms and haplotypes with uterine cervical cancer in Taiwanese women. PLoS One. 2014;9(9):e104038.
15.
OgawaYHirakawaKNakataB. Expression of intercellular adhesion molecule-1 in invasive breast cancer reflects low growth potential, negative lymph node involvement, and good prognosis. Clin Cancer Res. 1998;4(1):31–36.
16.
KimKBrownEEChoiCB. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis. 2012;71(11):1809–1814.
17.
LinCWChuangCYTangCH. Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development. PloS One. 2013;8(9):e72940.
18.
LuZXJiangPCaiJJXingY. Context-dependent robustness to 5′ splice site polymorphisms in human populations. Hum Mol Genet. 2011;20(6):1084–1096.
19.
RolandCLHarkenAHSarrMGBarnettCCJrICAM-1 expression determines malignant potential of cancer. Surgery. 2007;141(6):705–707.
20.
LinYCShunCTWuMSChenCC. A novel anticancer effect of thalidomide: inhibition of intercellular adhesion molecule-1-mediated cell invasion and metastasis through suppression of nuclear factor-kappaB. Clin Cancer Res. 2006;12(23):7165–7173.
21.
ThanopoulouEKotzamanisGPaterasIS. The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer. Tumour Biol. 2012;33(5):1429–1436.
22.
MaJMollstenAPraznyM. Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of Type 1 diabetes and diabetic nephropathy. Diabet Med. 2006;23(10):1093–1099.
23.
BielinskiSJReinerAPNickersonD. Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1 (sICAM-1). Atherosclerosis. 2011;216(2):390–394.
24.
AltomonteMFonsattiELamajE. Differential levels of soluble intercellular adhesion molecule-1 (sICAM-1) in early breast cancer and benign breast lesions. Breast Cancer Res Treat. 1999;58(1):19–23.
25.
ShifmanSBronsteinMSternfeldM. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet. 2002;71(6):1296–1302.
26.
ReaganJWPattenSFJrDysplasia: a basic reaction to injury in the uterine cervix. Ann N Y Acad Sci. 1962;97:662–682.
27.
CrumCP. Contemporary theories of cervical carcinogenesis: the virus, the host, and the stem cell. Mod Pathol. 2000;13(3):243–251.
28.
NairSANairMBJayaprakashPGRajalekshmyTNNairMKPillaiMR. ras and c-myc oncoproteins during tumor progression in the uterine cervix. Tumori. 1998;84(5):583–588.
29.
ColemanNGreenfieldIMHareJKruger-GrayHChainBMStanleyMA. Characterization and functional analysis of the expression of intercellular adhesion molecule-1 in human papillomavirus-related disease of cervical keratinocytes. Am J Pathol. 1993;143(2):355–367.
30.
NasuKNaraharaHEtohYKawanoYHirotaYMiyakawaI. Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and the expression of ICAM-1 mRNA in uterine cervical cancer. Gynecol Oncol. 1997;65(2):304–308.
31.
WalboomersJMJacobsMVManosMM. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–19.
32.
BoschFXManosMMMuñozN. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International Biological Study on Cervical Cancer (IBSCC) Study Group. J Natl Cancer Inst. 1995;87(11):796–802.
33.
ChenCALiuCYChouHH. The distribution and differential risks of human papillomavirus genotypes in cervical preinvasive lesions: a Taiwan Cooperative Oncologic Group Study. Int J Gynecol Cancer. 2006;16(5):1801–1808.
