A liquid fermentation culture of Fusarium acuminatum, endophytic in the root of Larrea tritentata, afforded a new furanopyrrolidone, 13α–hydroxylucilactaene (1), together with four known metabolites, NG–391 (2), NG–393 (3), enniatin A (4), and enniatin B (5). The structure and relative stereochemistry of 1 was established by extensive NMR spectral analysis and the known compounds 2 – 5 were identified by comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all compounds was evaluated in a panel of five human cancer cell lines [NCI–H460 (non-small cell lung), MCF–7 (breast), SF–268 (CNS glioma), MIA Pa Ca–2 (pancreatic carcinoma), PC-3M (metastatic prostate cancer)] and normal human fibroblast (WI–38) cells, and only enniatins A (4) and B (5) were shown to have significant cytotoxic activity.
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WijeratneEMK, TurbybilleTJ, ZhangZ, BigelowD, PiersonLAIII, VanEttenHD, WhitesellL, CanfieldLM, GunatilakaAAL. (2003) Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran desert. Journal of Natural Products, 66, 1567–1573.
11.
BashyalBP, WijeratneEMK, FaethSH, GunatilakaAAL. (2005) Globosumones A–C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum.Journal of Natural Products, 68, 724–728.
