Eight alkaloids (2–9) and two lignans (1 and 10) isolated from the stem bark of Zanthoxylum budrunga were tested against a panel of bacteria (both Gram positive and Gram negative) and fungi. Significant antibacterial activities were exhibited by all compounds against the test bacterial strains, except Klebsiella aerogenes. All compounds except the mixture of 2 and 3 showed reasonable antifungal activity against Aspergillus niger and Candida albicans. The MICs of the compounds against the test organisms were recorded in the range of 0.06–1.568 μmol.
BanerjeeH, PalS, AdityachaudhuryN. (1989) Occurrence of rutaecarpine in Zanthoxylum budrunga. Planta Medica, 55, 403.
5.
JoshiBS, PuarMS, MooreKM, PelletierSW. (1991) Isolation of dihydroavicine and rhetsinine from Zanthoxylum budrunga- the revision of H-1 and C-13 NMR spectral assignments for sanguinarine. Heterocycles, 32, 1365–1369.
6.
ShetgiriNP, RegeLN. (1998) Phytosterol and flavanone from roots of Zanthoxylum budrunga. Asian Journal of Chemistry, 10, 848–851.
7.
ShafiPM, SaiduttyA, CleryRA. (2000) Volatile constituents of Zanthoxylum rhetsa leaves and seeds. Journal of Essential Oil Research, 12, 179–182.
8.
RahmanMM, GrayAI. (2002) Antimicrobial constituents from the stem bark of Feronia limonia. Phytochemistry, 59, 73–77.
9.
RahmanMM, GrayAI. (2005) A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity. Phytochemistry, 66, 1601–1606.
PelterA, WardRS, RaoEV, SastryKV. (1976) Revised structures for pluviatilol, methyl pluviatilol and xanthoxylol: General methods for the assignment of stereochemistry to 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans. Tetrahedron, 32, 2783–2788.
CampbellWE, DavidowitzB, JacksonGE. (1990) Quinolinone alkaloids from an Agathosma species. Phytochemistry, 29, 1303–1306.
14.
TanakaH, AhnJW, KatayamaM, WadaK, MarumoS, OsakaY. (1985) Isolation of 2 ovicidal substances against 2-spotted spider-mite, Tetranychus urticae Koch, from Skimmia repens Nakai. Agricultural & Biological Chemistry, 49, 2189–2190.
15.
LeeSH, KimS, ParkJG, LeeES, JahngY. (2001) A simple synthesis of rutaecarpine. Heterocycles, 55, 1555–1559.
16.
UlubelenA. (1984) Alkaloids from Haplophyllum suaveolens. Phytochemistry, 23, 2123–2124.
17.
ShojiN, UmeyamaA, TakemotoT, KajiwaraA, OhizumiY. (1986) Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae). Journal of Pharmaceutical Sciences, 75, 612–613.
18.
CouillerotE, CaronC, ComoeL, AudranJC, MolinattiP, ZechesM, Men OlivierLL, JardillierJC, ChenieuxJC. (1994) Benzophenanthridine and furoquinoline accumulation in cell suspension cultures of Fagara zanthoxyloides. Phytochemistry, 37, 425–428.
19.
CamposO, DiPierroM, CainM, ManteiR, GawishA, CookJM. (1980) Selenium dioxide oxidations in the beta-carboline areaHeterocycles14, 975–984.
20.
AnjaneyuluASR, MurtyVS. (1981) Chemical examination of heartwood of Guazuma tomentosa Kunth. Indian Journal of Chemistry. Section B, 20, 85–87.
21.
SarkerSD, NaharL, KumarasamyY. (2007) Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals. Methods, 42, 321–324.
