Chemical investigation of the stem bark of Saraca indica has resulted in the isolation of a new lignan glycoside, saracoside, along with four known lignan glycosides lyoniside, icariside E3, (+)5′methoxyisolarciresinol-9′-O-β-D-glucopyranoside and nudiposide, and a phenolic glucopyranoside, 3,4,5– trimethoxyphenyl-β-D-glucopyranoside, which has been isolated for the first time from this species. The isolated lignan glycosides exhibit potent DNA topoisomerase IB inhibitory activity.
ThamDM, GardnerCD, HaskellWL. (1998) Potential health benefits of dietary phytoestrogens: A review of the clinical, epidemiological, and mechanistic evidence. Journal of Clinical Endocrinology Metabolism, 83, 2223–2235.
2.
GordalizaM, del CorralJMM, CastroMA, GarciaPA, San FelicianoA. (2001) Cytotoxic cyclolignans related to podophyllotoxin. Farmaco, 56, 297–304.
3.
ApersS, PaperD, BürgermeisterJ, BaronikovaS, Van DyckS, LemièreG, VlietinckA, PietersL. (2002) Antiangiogenic activity of synthetic dihydrobenzofuran lignans. Journal of Natural Products, 65, 718–720.
4.
CharltonJL. (1998) Antiviral activity of lignans. Journal of Natural Products, 61, 1447–1451.
5.
ZacchinoS, RodríguezG, PezzenatuG, OrellanaG, EnrizR, SierraMG. (1997) In vitro evaluation of antifungal properties of 8.O.4-neolignans. Journal of Natural Products, 60, 659–662.
6.
IwasakiT, KondoK, NishitaniT, KurodaT, HirakosoK, OhtaniA, TakashimaK. (1995) Arylnaphthalene lignans as a novel series of hypolipidemic agents raising high-density lipoprotein level. Chemical and Pharmaceutical Bulletin, 43, 1701–1705.
7.
LarsenA, PeterssonI, SvenssonB. (1989) Podophyllum derivatives (CPH82) compared with placebo in the treatment of rheumatoid arthritis. British Journal of Rheumatology, 28, 124–127.
8.
DucharmeY, BrideauC, DubéD, ChanC-C, FalgueyretJ-P, GillardJW, GuayJ, HutchinsonJH, McFarlaneCS, RiendeauD, ScheigetzJ, GirardY. (1994) Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl) thiazole and methoxytetrahydropyran hybrids. Journal of Medicinal Chemistry, 37, 512–518.
9.
BaldwinEL, OsheroffN. (2005) Etoposide, topoisomerase II and cancer. Journal of Medicinal Chemistry-Anicancer Agents, 5, 363–372.
10.
Wealth of India (2003) Vol 9, CSIR, New Delhi. 232–234
11.
SadhuSK, KhatunA, PhattanawasinP, OhtsukiT, IshibashiM. (2007) Lignan glycosides and flavonoids from Saraca asoca with antioxidant activity. Journal of Natural Medicine, 61, 480–482.
12.
OgawaM, OghiharaY. (1976) Studies on the constituents of Enkianthus nudipes V. A new lignan xyloside from the stems. Chemical and Pharmaceutical Bulletin24, 2102–2105.
13.
DasBB, SenN, DasguptaSB, Ganguly, MajumderHK. (2005) N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit. Journal of Biological Chemistry, 280, 16335–16344.
