Abstract
Objective:
To expand the adverse events associated with metronidazole to include nonconvulsive status epilepticus (NCSE).
Design:
Observational single case report of a rare association. Setting: Hospitalized lung transplant recipient treated with metronidazole for prevention of infection.
Patient:
A 56-year-old man with systemic symptoms, peripheral neuropathy, generalized seizure, and a subsequent acute deterioration of mental status due to NCSE.
Interventions:
Administration of midazolam was successful in terminating status epilepticus.
Main Outcome Measures:
Abrupt termination of NCSE was evident on continuous bedside electroencephalogam associated with clinical resolution of mental status.
Results:
Recovery occurred from NCSE eventually deteriorating to a fatal outcome. Conclusions: Metronidazole may be associated with successfully treated NCSE.
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