Aripiprazole use combined with depot antipsychotic medication: two cases demonstrating its ability to reduce prolactin levels in an adolescent forensic hospital
Free accessResearch articleFirst published online June, 2011
Aripiprazole use combined with depot antipsychotic medication: two cases demonstrating its ability to reduce prolactin levels in an adolescent forensic hospital
Many patients maintained on depot medication have raised prolactin levels, which can lead to a range of long-term medical problems. The addition of aripiprazole can reduce prolactin levels and restore sexual function in these patients. The cases described demonstrate the potential role of aripiprazole in a forensic setting.
Adan-ManesJ.Garcia-ParajuaP. (2009) Aripiprazole in combination with other antipsychotic drugs may worsen psychosis. J Clin Pharm Ther34: 245–246.
2.
AndersonJ.The interface with forensic services. In: BeerM.D.PereiraS.PatonC. (Eds.) (2008) Psychiatric Intensive Care2nd. Cambridge: Cambridge University Press, 191–201.
3.
BarnesT.R.E.Shingleton-SmithA.PatonC. (2009) Antipsychotic long-acting injections: Prescribing practice in the UK. Br J Psychiatry195: S37–S42.
4.
BoydA. (1995) Bromocriptine and psychosis: A literature review. Psychiatr Q66: 87–95.
5.
CasanuevaF.F.MolitchM.E.SchlechteJ.A.AbsR.BonertV.BronsteinM.D. (2006) Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas. Clin Endocrinol65: 265–273.
6.
Finn, S.E., Bailey, J.M., Schultz, R.T., Faber, R. (1990) Subjective utility ratings of neuroleptics in treating schizophrenia. Psychological Medicine 20: 843–848.
7.
HalbreichU.KinonB.J.GilmoreJ.A.KahnL.S. (2003) Elevated prolactin levels in patients with schizophrenia: mechanisms and related adverse effects. Psychoneuroendocrinology28(Suppl 1): 53–67.
8.
HendersonD.C.FanX.CopelandP.M.SharmaB.BorbaC.P.BoxillR. (2009) Aripiprazole added to overweight and obese olanzapine-treated schizophrenia patients. J Clin Psychopharmacol29: 165–169.
9.
HofferZ.S.RothL.R.MathewsM. (2009) Evidence for the partial dopamine-receptor agonist aripiprazole as a first-line treatment of psychosis in patients with iatrogenic or tumorogenic hyperprolactinemia. Psychosomatics50: 317–324.
10.
KuoJ.HwuH. (2008) Aripiprazole and Haloperidol: beneficial combination antipsychotic therapy for a schizophrenic patient. Clin Neuropharmacol31: 173–175.
11.
LanganJ.ShajahanP. (2010) Antipsychotic polypharmacy: a review of mechanisms, mortality and management. Psychiatrist34: 58–62.
12.
LehmanA.F.LiebermanJ.A.DixonL.B.McGlashanT.H.MillerA.L.PerkinsD.O. (2004) Practice guideline for the treatment of patients with schizophrenia. 2nd edn. Am J Psychiatry161(Suppl.): 1–56.
13.
LorenzR.A.WeinsteinB. (2007) Resolution of haloperidol-induced hyperprolactinaemia with aripiprazole. J Clin Psychopharmacol27: 524–552.
14.
MaguireG.A. (2002) Prolactin elevation with antipsychotic medications: mechanisms of action and clinical consequences. J Clin Psychiatry63(Suppl. 4): 56–62.
15.
MardenS.McQuadeR.StockE.KaplitaS.MarcusR.SaffermanA. (2003) Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials. Schizophr Res61: 123–136.
16.
MarkianosM.HatzimanolisJ.LykourasL. (2001) Neuroendocrine responsivities of the pituitary dopamine system in male schizophrenic patients during treatment with clozapine, olanzapine, risperidone, sulpiride or haloperidol. Eur Arch Psychiatry Clin Neurosci251: 141–146.
17.
MooreT.A.BuchananR.W.BuckleyP.F.ChilesJ.A.ConleyR.R.CrismonM.L. (2007) The Texas Medication Algorithm Project antipsychotic algorithm for schizophrenia: 2006 update. J Clin Psychiatry68: 1751–1762.
18.
National Institute for Health and Clinical Excellence (2009) Schizophrenia: core interventions. in the treatment and management of schizophrenia in adults in primary and secondary care (update). NICE Clinical Guideline82–82.
19.
PettyR.G. (1999) Prolactin and antipsychotic medications: Mechanism of action. Schizophr Res35(Suppl. 1): S67–S73.
20.
ShimJ.C.ShinJ.G.KellyD.L.JungD.U.SeoY.S.LiuK.H. (2007) Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic induced hyperprolactinaemia: a placebo-controlled trial. Am J Psychiatry164: 1404–1410.
