Looking beyond ectopic fat amount: A SMART method to quantify epicardial adipose tissue density

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References

Sacks

Fain

. Human epicardial adipose tissue: A review. Am Heart J 2007; 153: 907–917.

Rabkin

. Epicardial fat: properties, function and relationship to obesity. Obes Rev 2007; 8: 253–261.

Cherian

Lopaschuk

Carvalho

. Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease. Am J Physiol Endocrinol Metab 2012; 303: E937–E949.

Rietdorf K and MacQueen H. Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? Br J Pharmacol. Epub ahead of print 24 November 2016. DOI: 10.1111/bph.13678.

Mazurek

. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003; 108: 2460–2466.

Sacks

Fain

. Human epicardial fat: what is new and what is missing? Clin Exp Pharmacol Physiol 2011; 38: 879–887.

Hirata

Tabata

Kurobe

. Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue. J Am Coll Cardiol 2011; 58: 248–255.

Karastergiou

Evans

Ogston

. Epicardial adipokines in obesity and coronary artery disease induce atherogenic changes in monocytes and endothelial cells. Arterioscler Thromb Vasc Biol 2010; 30: 1340–1346.

Venteclef

Guglielmi

Balse

. Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines. Eur Heart J 2015; 36: 795–805a.

10.

Silaghi

Achard

Paulmyer-Lacroix

. Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status. AJP Endocrinol Metab 2007; 293: E1443–E1450.

11.

Sacks

Fain

Holman

. Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: epicardial fat functioning as brown fat. J Clin Endocrinol Metab 2009; 94: 3611–3615.

12.

Ojha

Fainberg

Wilson

. Gene pathway development in human epicardial adipose tissue during early life. JCI Insight 2016; 1: e87460–e87460.

13.

Moreno-Santos

Pérez-Belmonte

Macías-González

. Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease. J Transl Med 2016; 14: 243–243.

14.

Fitzgibbons

Czech

. Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations. J Am Heart Assoc 2014; 3: e000582–e000582.

15.

Mahabadi

Berg

Lehmann

. Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study. J Am Coll Cardiol 2013; 61: 1388–1395.

16.

Ito

Nasu

Terashima

. The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis. Eur Heart J Cardiovasc Imaging 2012; 13: 408–415.

17.

Zhou

Zhang

H-W

Tian

. Influence of increased epicardial adipose tissue volume on 1-year in-stent restenosis in patients who received coronary stent implantation. J Geriatr Cardiol JGC 2016; 13: 768–775.

18.

Homsi

Sprinkart

Gieseke

. 3D-Dixon cardiac magnetic resonance detects an increased epicardial fat volume in hypertensive men with myocardial infarction. Eur J Radiol 2016; 85: 936–942.

19.

Franssens BT, Nathoe HM, Leiner T, et al. Relation between cardiovascular disease risk factors and epicardial adipose tissue density on cardiac computed tomography in patients at high risk of cardiovascular events. Eur J Prev Cardiol. 2017; 24: 660–670.

20.

Rosenquist

Pedley

Massaro

. Visceral and subcutaneous fat quality and cardiometabolic risk. JACC Cardiovasc Imaging 2013; 6: 762–771.

21.

Simons

Algra

van de Laak

. Second manifestations of ARTerial disease (SMART) study: rationale and design. Eur J Epidemiol 1999; 15: 773–781.

22.

Tanami

Jinzaki

Kishi

. Lack of association between epicardial fat volume and extent of coronary artery calcification, severity of coronary artery disease, or presence of myocardial perfusion abnormalities in a diverse, symptomatic patient population: results from the CORE320 multicenter study. Circ Cardiovasc Imaging 2015; 8: e002676–e002676.

23.

Gaborit

Kober

Jacquier

. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat. Int J Obes 2005 2012; 36: 422–430.

24.

Park

Ghemigian

. Epicardial and paracardial adipose tissue volume and attenuation – association with high-risk coronary plaque on computed tomographic angiography in the ROMICAT II trial. Atherosclerosis 2016; 251: 47–54.

25.

Alvey NJ, Pedley A, Rosenquist KJ, et al. Association of fat density with subclinical atherosclerosis. J Am Heart Assoc. Epub ahead of print 28 August 2014. DOI: 10.1161/JAHA.114.000788.

26.

Gaborit

Venteclef

Ancel

. Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location. Cardiovasc Res 2015; 108: 62–73.

27.

Konishi

Sugiyama

Sato

. Pericardial fat inflammation correlates with coronary artery disease. Atherosclerosis 2010; 213: 649–655.

28.

Kusayama

Furusho

Kashiwagi

. Inflammation of left atrial epicardial adipose tissue is associated with paroxysmal atrial fibrillation. J Cardiol 2016; 68: 406–411.