Hydroxyapatite (HA) has been widely used as a biocompatible ceramic in many areas of medicine, but mainly for contact with bone tissue, due to its resemblance to mineral bone. In mammals, the skeleton presents a carbonated and partially substituted apatite, based on nanocrystal aggregates, and associated with collagen, building up 3-D structures present in various bone tissue conformations like trabecular or cancellous bone. There has been growing interest in developing bioactive synthetic ceramics that could closely mimic natural apatite characteristics. This review presents some of the most well known forms of obtaining, by precipitation methods, nanophased HA. Some traditional and more recent developments vis-à-vis the possible HA nanoparticles applications are discussed.(Journal of Applied Biomaterials & Biomechanics 2004; 2: 74–80)
WebsterT.J., SiegelR.W., BiziosR.Enhanced surface and mechanical properties of nano phase ceramics to achieve orthopaedic/dental implant efficacy.Key Engineering Materials2001; 192–5: 321–4.
2.
WebsterT.J., ErgunC., DoremusR.H., SiegelR.W., BiziosR.Enhanced functions of osteoblasts on nanophase ceramics.Biomaterials2000; 21: 1803–10.
3.
WebsterT.J.Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics.J Biomed Mater Res2000; 51: 475–83.
4.
BouyerE., GitzhoferF., BoulosM.I.Morphological study of hydroxyapatite nanocrystal suspension.J Mater Sci Mater Med2000; 11: 523–31.
5.
JarchoM., KayJ.F., GumaerK.I., DoremusR.H., DrobeckH.P.Tissue, cellular and subcellular events at bone-ceramic hydroxyapatite interface.J Bioeng1977; 1: 79–92.
6.
YubaoL., de GrootK., de WijnJ., KleinC.P.A.T., MeerS.V.D.Morphology and composition of nanograde calcium phosphate needle-like crystals formed by simple hydrothermal treatment.J Mater Sci Mater Med1994; 5: 326–31.
7.
YubaoL., KleinC.P.A.T., de WijnJ., WolkeJ., de GrootK.Morphology and phase structure of nanograde boneapatite-like rodshaped crystals. In: DucheyneP., and ChristiansenD., eds. Bioceramics.Philadelphia, USA: Butterworth-Heinemann1993; 173–8.
8.
JanackovicD., Petrovic-PrelevicI., Kostic-GvozdenovicL., PetrovicR., JokanovicV., UskokovicD.Influence of synthesis parameters on the particle sizes of nanostructured calcium-hydroxyapatite.Key Engineering Materials2001; 192–5: 203–6.
9.
ManuelC.M., FerrazM.P., MonteiroF.J.Nanoparticle and microporous structures of hydroxyapatite. Proceedings of the 17th European Society for Biomaterials. Barcelona, Spain, 2002; T153.
10.
ManuelC.M., FerrazM.P., MonteiroF.J.Synthesis of hydroxyapatite and tricalcium phosphate nanoparticles - preliminary studies.Key Engineering Materials2003; 240–242: 555–8.
11.
TasA.C.Synthesis of biomimetic Ca-hydroxyapatite powders at 37 degrees C in synthetic body fluids.Biomaterials2000; 21: 1429–38.
12.
KokuboT.Surface chemistry of bioactive glass ceramics.Journal of Non-Crystaline Solids1990; 120: 138–51.
13.
OhtsukiC., KokuboT., YamamuroT.Mechanisms of HA formation of CaO-SiO2-P2O5 glasses in simulated body fluid.Journal of Non-Crystaline Solids1992; 143: 84–92.
14.
LiP., NakanishiK., KokuboT., de GrootK.Introduction and morphology of HA precipitated from metastable simulated body fluids on sol-gel prepared silica.Biomaterials1993; 14: 963–8.
15.
LiP., KangasniemiI., de GrootK., KokuboT.Bonelike hydroxyapatite induction by a gel-derived titania on a titanium substrate.J Am Ceram Soc1994; 77: 1307–12.
16.
LiP., KangasniemiI., de GrootK., KokuboT., Yli-UrpoA.U.Apatite crystallization from metastable calcium phosphate solution on sol-gel prepared silica.Journal of Non-Crystaline Solids1994; 168: 281–6.
17.
KokuboT., MiyajiF., KimH.M., NakamuraT.Spontaneous formation of bone like apatite layer on chemically treated titanium metals.J Am Ceram Soc1996; 79: 1127–9.
18.
van BlitterswijkC.A., GroteJ.J., KuijpersW., Blok-van HoekC.J.G., DaemsW.T.Bioreactions at tissue-hydoxyaptite interface.Biomaterials1985; 6: 243–51.
19.
LotyC., LotyS., KokuboT., ForestN., SautierJ.M.Pre-fabricated biological apatite formation on a bioactive glass-ceramic promotes in vitro differentiation of fetal rat chondrocytes. In: SedelL., ReyC. eds. Bioceramics.Paris: Elsevier Science Publishers1997; 219–22.
20.
LotyC., SautierJ.M., BoulekbacheH., KokuboT., KimH.M., ForestN.In vitro bone formation on a bone-like apatite layer prepared by a biomimetic process on a bioactive glass-ceramic.J Biomed Mater Res2000; 49: 423–34.
21.
BarréreF., van der ValkC.M., DalmeijerR.A.J., van BlitterswijkC.A., de GrootK., LayrolleP.In vitro and in vivo studies of biomimetic octacalcium phospate and carbonate apatite coatings on titanium implants.J Biomed Mater Res2003; 64A: 378–87.
22.
BarréreF., LayrolleP., van BlitterswijkC.A., de GrootK.Physical and chemical characteristic of plasma sprayed and biomimetic apatite coating.Bioceramics1999; 12: 125–8.
23.
HabibovicP., BarréreF., van BlitterswijkC.A., de GrootK., LayrolleP.Biomimetic hydroxyapatite coating on metal implants.J Am Ceram Soc2002; 85: 517–22.
24.
BarréreF.Osteogenecity of octacalcium phospate coatings applied on porous metal implants.J Biomed Mater Res2003; 66A: 779–88.
25.
LeeuwenburghS., LayrolleP., BarréreF.Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro.J Biomed Mater Res2001; 56: 208–15.
26.
LiuY., LayrolleP., van BlitterswijkC.A., de GrootK.Biomimetic coprecipitation of calcium phosphate and bovine serum albumin on titanium alloy.J Biomed Mater Res2001; 57: 327–35.
27.
WenH.B., de WijnJ.R., LiS.H.Incorporation of bovine serum albumin in calcium phosphate coating on titanium.J Biomed Mater Res1999; 46: 245–52.
28.
StigterM., de GrootK., LayrolleP.Incorporation of tombramycin into biomimetic hydroxyapatite coating on titanium.Biomaterials2002; 23: 4143–53.
29.
DuanY.R., WangC.Y., ChenJ.Y., ZhangX.D.A study of bone-like apatite formation on calcium phosphate ceramics in different simulated body fluids (SBF).Key Engineering Materials2004; 254–256: 351–4.
30.
KimH.M., KanekoH., KawashitaM., KokuboT., NakamuraT.Mechanisms of apatite formation on anodically oxidixed titanium metal in simulated body fluid.Key Engineering Materials2004; 254–256: 741–4.
31.
KokuboT., HimenoT., KimH.M., KawashitaM., NakamuraT.Process of bonelike apatite formation on sintered hydroxyapatite in serum-containing SBF.Key Engineering Materials2004; 254–256: 139–42.
GrossK.A., ChaiC.S., KannangaraG.S.K., Ben-NissanB., HanleyL.Thin hydroxyapatite coatings via sol-gel synthesis.J Mater Sci Mater Med1998; 9: 839–43.
34.
MasudaY., MatubaraK., SakkaS.Synthesis of hydroxyapatite from metal alkoxides through sol-gel technique.J Ceram Soc1990; 98: 1266–77.
35.
ChaiC.S., GrossK.A., Ben-NissanB.Critical ageing of hydroxyapatite sol-gel solution.Biomaterials1998; 19: 2291–6.
36.
JillavenkatesaA., CondrateR.A.Sol-gel processing of hydroxyapatite.J Mater Sci Mater Med1998; 33: 4111–9.
37.
BrendelT., EngelA., RusselC.Hydroxyapatite coating by polymeric route.J Mater Sci Mater Med1992; 3: 175–9.
38.
TakahashiH., YashimaM., KakihanaM., YoshimuraM.Synthesis of stoichiometric hydroxyapatite by a gel route from the aqueous solution of citric and phosphoneacetic acids.European Journal of Solid State Inorganic Chemistry1995; 32: 829–35.
39.
HaddowD.B., JamesP.F., Van NoortR.Characterization of sol-gel surfaces for biomedical applications.J Mater Sci Mater Med1996; 7: 255–60.
40.
LiuD.M., TroczynskiT., TsengW.J.Water-based sol-gel synthesis of hydroxyapatite process development.Biomaterials2001; 22: 1721–30.
ShirkhanzadehM.Direct formation of nanophase hydroxyapatite cathodically polarised electrodes.J Mater Sci Mater Med1998; 9: 67–72.
43.
MansoM., JimenezC., MorantC., HerreroP., Martinez-DuartJ.M.Electrodeposition of hydroxyapatite coatings in basic conditions.Biomaterials2000; 21: 1755–61.
44.
KomarovV.F., KibalchitzV.Precipitation of apatite through highly saturated solutions.Moscow Univ Bull Chem Dic1979: 2680–85.
45.
DuC., CuiF.Z., FengQ.L., ZhuX.D., de GrootK.Tissue response to nano-hydroxyapatite/collagen composite implants in marrow cavity.J Biomed Mater Res1998; 42: 540–8.
46.
Muller-MaiC.M., StuppS.I., VoigtC., GrossK.A.Nanoapatite and organoapatite implants in bone: Histology and ultrastructure of the interface.J Biomed Mater Res1995; 29: 9–18.
47.
YamaguchiI., TokuchiK., FukuzakiH.Preparation and mechanical properties of chitosan/hydroxyapatite nanocomposites.Key Engineering Materials2001; 192–195: 673–9.
48.
YamaguchiI., TokuchiK., FukuzakiH.Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites.J Biomed Mater Res2001; 55: 20–7.
49.
ItohS., KikuchiM., KoyamaY., TakakudaK., ShinomiyaK., TanakaJ.Development of an artificial vertebral body using a novel biomaterial, hydroxyapatite/collagen composite.Biomaterials2002; 23: 3919–26.
50.
KikuchiM., ItohS., IchinoseS., ShinomiyaK., TanakaJ.Self-organization mechanism in a bone like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo.Biomaterials2001; 22: 1705–11.
51.
ItohS., KikuchiM., TakakudaK.The biocompatibility and osteoconductive activity of a novel hydroxyapatite/collagen composite biomaterial, and its function as a carrier of rhBMP-2.J Biomed Mater Res2001; 54: 445–53.
52.
DuC., CuiF.Z., ZhuX.D., de GrootK.Three-dimensional nano-HAp/collagen matrix loading with osteogenic cells in organ culture.J Biomed Mater Res1999; 44: 407–15.
53.
TenHusenK., MartinR.I., KlimkiewiczM., BrownP.W.Formation and properties of a synthetic one composite: Hydroxyapatite-collagen.J Biomed Mater Res1955; 29: 803–10.
54.
ChoC., KobayashiA., TakeiR., IshiharaT., MaruyamaA., AkaikeT.Receptor-mediated cell modulator delivery to hepatocyte using nanoparticles coated with carbohydrate-carrying polymers.Biomaterials2001; 22: 45–51.
55.
PaulW., SharmaC.P.Porous hydroxyapatite nanoparticles for intestinal delivery of insulin.Trends in Biomaterials and Artificial Organs2001; 14: 37–8.
56.
KanoS., YamazakiA.R. O., OhgakiM., AkaoM., AokiH.Application of hydroxyapatite-sol as drug carrier.Biomed Mater Eng1994; 4: 283–90.
