Incidence and Treatment Trends of Achilles Tendon Ruptures in Finland: A Nationwide Study

Methods

This is a register study based on data from the NHDR and PHCR, both of which are maintained by the National Institute for Health and Welfare. The NHDR was founded in 1967, and data reporting to the register are obligatory for all public and private hospitals in Finland. The PHCR similarly receives data on all patient encounters within the public primary health care system (primary health care centers) in Finland, and it has been in use since 2011. The registers contain data on age, sex, domicile, external cause of injury, type of injury, primary and secondary diagnoses, type of hospital (public or private), duration of hospital stay, and possible operations performed during the hospital stay. The validity of the NHDR has been found to be good, especially when it comes to orthopaedic trauma. ^9,14,22 Ethical approval was received for the study protocol.

The databases were searched for all records with a primary or secondary diagnosis code of S86.0, “injury of Achilles tendon” (International Classification of Diseases, 10th Revision [ICD-10]) between January 1, 1997, and December 31, 2019. The NHDR was also searched for all records with the procedural code NHL10, “suture or reinsertion of Achilles tendon” (Nordic Classification of Surgical Procedures [NCSP]). This was done to identify all nonoperatively and operatively treated patients in both primary health care centers and hospitals in Finland. All duplicate cases between the 2 registers were excluded. All subsequent records with diagnosis code S86.0 were excluded to include only acute ATRs for the incidence calculations. Only records with operative treatment within 30 days of injury were included in the operative treatment incidence calculation to describe firsthand choice of operative treatment, apart from the treatment of ATR sequelae or salvage of failed nonoperative treatment. Only patients 16 years of age and older were included. The incidence was calculated based on the annual adult population size (persons aged ≥16 years) obtained from Statistics Finland. ²¹ Data on patient age, sex, procedures performed during the hospital stay, injury mechanism, and external cause of injury were also collected. A flowchart of patient inclusion in the study is shown in Figure 1.

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Figure 1.

Patient-inclusion flowchart. ATR, Achilles tendon rupture; NCSP, Nordic Classification of Surgical Procedures; NHDR, National Hospital Discharge Register; NHL10, PHCR, Finnish Register of Primary Health Care Visits.

Continuous variables were summarized with means with standard deviations and ranges. The difference in the treatment method of ATRs between sexes was analyzed using the chi-square test. Incidence calculations as well as other statistical reporting were performed using SAS software Version 9.4 of the SAS System for Windows (SAS Institute).

Results

A total of 30,162 acute ATRs were registered in the NHDR and the PHCR during the 23-year study period. Of these cases, 13,242 (44%) were treated operatively and 16,920 (56%) nonoperatively. Overall, 2178 patients were treated nonoperatively in primary health care centers and registered only in the PHCR (Figure 2). The overall incidence of ATRs increased between 1997 and 2019 from 17.3 to 32.3 per 100,000 person-years (Figure 3A). The rise in incidence occurred mainly during the first half of the study period (1997-2011), forming a plateau during the latter half.

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Figure 2.

Frequency of Achilles tendon rupture (ATR). NHDR, National Hospital Discharge Register; PHCR, Finnish Register of Primary Health Care Visits.Vertical line indicates the introduction of the PHCR and its data.

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Figure 3.

(A) Overall and sex-adjusted incidence of Achilles tendon rupture (ATR). (B) Incidence of operative and nonoperative treatment for ATR. (C) Age-adjusted incidence of ATR. (D) Age-adjusted incidence of operative treatment for ATR.

The incidence of nonoperative treatment increased considerably (from 3.7 to 27.5 per 100,000 person-years), whereas the incidence of operative treatment decreased (from 13.6 to 4.9 per 100,000 person-years) during the study time (Figure 3B). The decrease in operative treatment occurred from 2008 onward.

The incidence of ATRs rose in both sexes across the study period (Figure 3A). ATRs were most frequent in men (22,735 cases; 75% of all cases) and in the age group of 30 to 49 years. In 1997, the incidences were 28.6 and 6.76 per 100,000 person-years for men and women, respectively. In 2019, the incidence for men was almost threefold compared with that for women, with 48.8 compared to 16.6 per 100,000 person-years, respectively. There was a statistically significant difference in the treatment method of ATRs between sexes during the study period: men were more often treated operatively (47%) than women (36%) (P < .0001).

The mean age of the patients was 44 ± 12.6 years (range, 16-91 years) among operatively treated and 53 ± 16.3 years (range, 16-101 years) among nonoperatively treated patients. The age-adjusted incidence of ATRs increased in every age group during the study period but most significantly in the age group ≥70 years (from 6.1 to 30.1 per 100,000 person-years) (Figure 3C). The incidence of operative treatment decreased in every age group (Figure 3D).

The most commonly reported injury mechanisms were sports injuries (7279 cases), recreational injuries (5082 cases), and domestic accidents (1522 cases).

Discussion

We found that the incidence of ATRs increased in the Finnish population between 1997 and 2019, especially in the older age groups. Despite the increase in ATR incidence, the incidence of operative treatment of ATRs decreased from 13.6 to 4.9 per 100,000 person-years during our study period. A shift toward more nonoperative treatment was observed in all age groups.

The global reported incidence of ATRs increased in the 2000s. ^3,5,8,11,19 The Nordic countries are well represented in this area of study, but although there are published results from Danish and Swedish national registers, there have been no previous studies covering the national incidence of ATRs in Finland. In 2015, Lantto et al ¹¹ published an article on ATR incidence based on a cohort of 515 patients treated in Oulu, Finland, from 1979 to 2011. There was an almost 10-fold increase in the incidence of ATRs (per 100,000 person-years), rising from 2.1 to 21.5 in 2011. Our findings from the first half of our study period were comparable. During the second half of our study period, the increase in ATR incidence seemed to plateau. A coinciding similar trend has been shown in recent Japanese national register data from 2010 to 2017. ²⁶ Huttunen et al ⁸ studied the incidence of ATRs and their treatment methods in Sweden between 2001 and 2012; here, the ATR incidence (per 100,000 person-years) rose in both sexes in the Swedish population, increasing from 47.0 to 55.2 for men and from 12.0 to 14.7 for women. Ganestam et al ⁵ published a similar study based on data from the Danish population between 1994 and 2013. The overall ATR incidence rose from 26.95 to 31.17 in Denmark. The overall and sex-adjusted incidences in these two studies are comparable with what we see in the Finnish population in the overlapping time periods. The more pronounced rise in incidence in the elderly age groups compared with younger ones is evident in all three Nordic countries, a fact that may be due to the aging population increasingly taking part in high-demand sports and activities. This is in line with reports from the United Kingdom, the rest of Europe, North America, and Asia. ^6,12

The Swedish and Danish hospital discharge registers resemble the NHDR in their data-collection principles: They cover both inpatient and outpatient visits, but, like the NHDR, they do not cover patients treated in primary health care. To the best of our knowledge, this is the first national register study to include ATRs treated in both hospitals and primary health care centers. The introduction of the PHCR in 2011 coincides with a marked increase in ATR incidence and nonoperative treatment incidence for ATRs. It is possible that previous studies based on data only from hospital records have underestimated ATR and nonoperative treatment incidences because data from primary healthcare have not been available. ATRs, as well as several other injuries, do often not require hospitalization or referral to a specialist unit when treated nonoperatively.

The optimal treatment method for ATRs has been widely studied in recent years. Results from numerous RCTs comparing operative and nonoperative treatment have been pooled into several meta-analyses. ^{2,4,15 –18,20,23} Essentially, nonoperative treatment is associated with a greater risk of rerupture (risk ratio ranging from 0.27 to 0.43 in favor of surgery ^16,18 ), whereas operative treatment is associated with surgery-related complications (overall complication risk ratio ranging from 2.76 to 6.06 in favor of nonoperative treatment ^16,18 ), especially infections (risk ratio ranging from 3.43 to 6.69 ^17,18 ), thromboembolic events, and sural nerve damage. However, unlike the risks associated with open surgery, the risk of rerupture has been disputed, and some conflicting interpretations have been presented in the meta-analyses mentioned above. ^{2,4,15 –18,20,23}

Operative treatment was historically considered superior to nonoperative treatment, as reruptures were a frequent concern with nonoperative care. ¹⁰ Nonoperative treatment, originally comprising rigid cast immobilization and limited weightbearing, has evolved alongside increasing knowledge of tendon healing principles into a functional rehabilitation strategy with early protected range of motion and early weightbearing. In their 2010 RCT comparing operative and functional nonoperative treatment of ATRs, Willits et al ²⁵ demonstrated no difference in rerupture risk in favor of operative treatment. Wallace et al ²⁴ published similar findings in their RCT a year later. A 2012 meta-analysis by Soroceanu et al ²⁰ pointed out the advantage of early range of motion and that patients with this applied in nonoperative treatment had no greater risk of rerupture compared with operative treatment. Another 2013 meta-analysis by Van der Eng et al ²³ concluded that rehabilitation with early weightbearing led to lower rerupture rates, with no difference between operatively and nonoperatively treated patients. Some later meta-analyses interpret the evidence on rerupture rates in favor of operative treatment and have highlighted the advantages of, for example, minimally invasive surgical techniques and the potentially earlier return to work when compared with nonoperative treatment. ^2,4,17 Others, on the other hand, have found the rerupture risk difference between treatment groups to be small compared to the overall complication risk difference (1.6% vs 3.3%, respectively), favoring nonoperative treatment, and that across contemporary treatments (prolonged cast immobilization excluded), the risk of rerupture is probably no different between treatment groups. ^15,16 The importance of careful individual consideration of the potential risks and advantages between treatment options alongside shared decision making has been highlighted in these two last studies. ^15,16 It should be noted that all these abovementioned meta-analyses are derived from RCTs, which are quite heterogeneous in their methodology and rehabilitation protocols for nonoperative and operative treatments. A large portion of the RCTs date back to the first decade of the 21st century or earlier, when functional nonoperative treatment was less mainstream compared to more recent times. Detailed and tested functional nonoperative treatment protocols have later been described and published (for example, the results of the UK-based SMART protocol ⁷ and UKSTAR multicenter RCT ¹ ).

Regardless of whether we consider the available evidence in favor of operative or nonoperative treatment, there are reports of decreasing operative treatment rates for ATRs. In Sweden and Denmark, operative treatment rates have been decreasing since the latter half of the first decade of the 21st century. ^5,8 In 2015, Mattila et al ¹³ reported the incidence of operative treatment of ATRs in Finland between 1987 and 2011. The incidence increased for men and women from 11.1 and 2.5 to 20.5 and 4.2 per 100,000 person-years, respectively; this study pointed out the increasing rate of operative treatment, which rose steadily up to the end of the first decade of the 21st century, peaking from 2007 to 2008, after which an impending decline was noted. We have now verified that this decline in the operative treatment of ATRs has continued. We have also shown that the decline in surgery incidence is a real change in practice, not the result of a possible simultaneous decline in ATR incidence.

Conclusion

The incidence of ATRs increased in Finland from 1997 to 2019. However, the rise seemed to plateau around 2010. The proportion of nonoperative treatment increased continuously throughout the study period. This change in treatment principle is in line with reported international trends and current literature, which has shown that when compared with operative treatment, nonoperative treatment provides comparable functional results with only slightly increased rerupture risk, without the complications associated with surgery.