Abstract
Badmaev V, Vik H, Stohs SJ, Galluzzo F. Safety and toxicological evaluation of NXT15906F6 (TamaFlex®) A food-derived botanical composition containing standardized extracts of Tamarindus indica seeds and Curcuma longa rhizomes. Toxicology Research and Application 2018; 2: 1-14. DOI: 10.1177/2397847317749240
The authors of the above article would like to highlight the following corrections:
p. 1, In the second line of the abstract Curcuma longa rhizome was mistakenly described as an ethanol extract, hence, “NXT15906F6 contains standardized aqueous ethanol/aqueous extracts of Tamarindus indica seeds and an ethanol extract of Curcuma longa rhizome in a 2:1 ratio.” should read, “NXT15906F6 contains standardized ethanol/aqueous extracts of Tamarindus indica seeds and aqueous ethanol extract of Curcuma longa rhizome in a 2:1 ratio.”
p. 2, The third paragraph of the Introduction should read, “NXT15906F6 is a novel anti-inflammatory botanical formula that combines aqueous ethanol and aqueous extracts of Tamarindus indica fruit seeds (i.e. tamarind; Leguminosae family) and aqueous ethanol extract of Curcuma longa rhizome (i.e. turmeric; Zingiberaceae family).”
p. 2, The first paragraph of ‘Test item’ section of Materials and Methods should read, “NXT15906F6 is an herbal blend containing the extracts of the T. indica seeds and C. longa rhizome. Dried seeds of T. indica were pulverized and extracted with aqueous ethanol. The leftover residue was extracted with water. The extracts were concentrated independently under vacuum and blended in a 9:1 ratio to obtain a novel T. indica seed extract (TSE). Each batch was identified by high-performance thin-layer chromatography and standardized to contain not less than (NLT) 90% proanthocyanidins.”
p. 2, The second paragraph of the ‘Test item’ section of Materials and Methods should read “Dried C. longa rhizomes were pulverized, extracted with aqueous ethanol, and concentrated to a thick paste under vacuum. The C. longa rhizome extract (CLE) contains a minimum of 15% total curcuminoids as determined by high-performance liquid chromatography. The test item NXT15906F6 is a blend of TSE, CLE, and excipients in a 6:3:1 ratio. It was produced in a cGMP-compliant manufacturing facility and stored at room temperature. The test item contained 8% (w/w) microcrystalline cellulose powder and 2% (w/w) Syloid silica as excipients. NXT15906F6 was standardized to contain NLT 65% of proanthocyanidins and 3% of total curcuminoids.”
p. 3, The study location of Liveon Biolabs Pvt. LTd (Karnataka, India), described in ‘Experimental animals and housing conditions’, within the Materials and Methods section, as well as in the Funding statement at the end of the paper is incorrect. All experiments were conducted at Laila Nutraceuticals R & D Research Centre, Andhra Pradesh, India.