Abstract
Objective
We investigated the relationships between the risk for coronary heart disease (CHD), psoriatic arthritis activity, and red blood cell aggregation (RBCA).
Methods
Our study comprised 130 patients with psoriatic arthritis (mean age, 41.7 ± 9.8) whose mean duration of psoriatic arthritis was 7 (IQ-range, 2.5–13) years and disease activity score (DAS) was 3.86 (IQ-range 2.72–5.14). We measured psoriatic arthritis DAS, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), time to formation of linear aggregates formation (T1 [s]), strength of the largest aggregates (la2.5[%]), hydrodynamic strength of aggregates (β [s−1]), velocity of aggregates formation (Kt [r.u.]), relative risk of CHD (RR CHD), and 10-year absolute risk (AR) of total and hard CHD in all patients. Statistical analysis was performed with Spearman correlation (R).
Results
Significant correlations were found between RBCA (T1/la2.5 /Kt) and DAS (R = −0.32/0.32/0.33), CRP (R = −0.34/0.41/0.47), and ESR (R = −0.34/0.35/0.42). RBCA (T1/Kt) significantly correlated with RR CHD (R = −0.32/0.35), total CHD (R = −0.32/0.31), and hard CHD risks (R = −0.31/0.30); no correlation was found between risk for CHD and psoriatic arthritis activity.
Conclusion
RBCA may be useful for assessment of psoriatic arthritis activity and CHD risk.
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