Brodalumab for Treatment-Resistant Psoriasis: Case Reports and Safety Update

Abstract

Introduction:

Brodalumab is an interleukin-17 receptor blocker that is effective for the treatment of psoriasis. However, due to a Food and Drug Administration black box warning on depression and suicide, many providers are hesitant to use this agent despite its efficacy.

Methods:

We present the cases of 2 brothers seen at our clinic with treatment-resistant psoriasis who were both successfully treated with brodalumab, despite failing 6 other biologics. We also review the safety profile of brodalumab regarding the currently available evidence on the increased risk of suicidality or depression in patients treated with brodalumab.

Results:

Both patients achieved completely clear skin and maintained clearance on brodalumab.

Discussion:

Brodalumab appears to be an effective agent in severe treatment-resistant cases of psoriasis. In addition, a causal relationship between increased risk of suicidality or depression and brodalumab use has not been established.

Keywords

interleukin 17 inhibitor biologic treatment psoriasis case report brodalumab treatment outcomes

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