Abstract
Microbubble ultrasound contrast agents were developed for use in the macrovascular circulation as an adjunct to a colour Doppler ultrasound examination — 'Doppler-rescue'. Although technical developments and the unique behavior of microbubble contrast in the liver have eclipsed the original perceived use, there remains an important role for microbubble contrast in the peripheral vasculature. This review details the applications of microbubble contrast agents in 'Doppler-rescue', with illustrations of important disease processes suitable for examination with microbubble contrast in order to reduce further radiological investigations.