Study of biodegradable ceramic bone graft substitute

Abstract

The aim of the present study was to obtain a biodegradable porous calcium phosphate implants as a synthetic bone graft substitute. The calcium phosphate used in the present study consisted of hydroxyapatite (HA) and dicalcium phosphate anhydrous (DCP). Porous bioceramic was fabricated by a foam casting method. By polyurethane foam and slurry containing HA/DCP (3 : 1 weight ratio) powder, water and additives a high porous structure with ∼70% was created. The X-ray diffractometry revealed that the β-tricalcium phosphate (β-TCP) formation is major phase. Surface morphology analysis and porosity evaluations were performed. The variation in the compressive strength, elastic modulus and dissolution behaviour of immersed synthetic bone graft in simulated physiological solution investigated.

Keywords

POROUS CALCIUM PHOSPHATE SYNTHETIC BONE GRAFT SUBSTITUTE BIODEGRADABLE

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References

Raynaud

, Champion

, BernacheE-Assollant

and Thomas

: Biomaterials, 2002, 23, 1065–1072.

and Leng

: Biomaterials, 2005, 26, 1097–1108.

Tas

A. C.

, Korkusuz

, Timucin

and Akkas

: J. Mater. Sci., 1997, 8, 91–96.

Jarcho

: Clin. Orthop. Rel Res., 1981, 157, 259–278.

Klein

, Driessen

A. A.

and de Groot

: Biomaterials, 1984, 5, 157–160.

, Currier

B. L.

and Yaszemsk

M. J.

: Curr. Opin. Orthop., 2000, 11, 383–390.

Baksh

, Davies

J. E.

and Kim

: J. Mater. Sci., 1998, 9, 743–748.

Kikuchi

, Koyama

, Takakuda

, Miyairi

and Shirahama

: J. Biomed. Mater. Res., 2002, 62, 256–272.

Agrawal

C. M.

and Ray

R. B.

: J. Biomed. Mater. Res., 2001, 55, 141–150.

10.

Klein

C. P.

, Patka

and den Hollander

: in ‘Handbook of bioactive ceramics: calcium phosphate and hydroxylapatite ceramics’, (ed. T. Yamamuro et al.), Vol. II, 53–60; 1990, Boca Raton, CRC Press.

11.

Tampieri

, Celotti

, Sprio

, Delcogliano

and Franzese

: Biomaterials, 2001, 22, 1365–1370.

12.

Prado

M. H.

da Silva

A. F.

Lemons

I. R.

Gibson

J. M. F.

Ferreira and Santos

J. D.

: J. Non-Cryst. Solids, 2002, 304, 286–292.

13.

Liu

D. M.

: Biomaterials, 1996, 17, 1955–1957.

14.

Flautre

, Descamps

, Delecourt

, Blary

M. C.

and Hardouim

: J. Mater. Sci., 2001, 12, 679–682.

15.

Chu

T. M. G.

, Halloran

J. W.

, Hollister

S. J.

and Feinberg

S. E.

: J. Mater. Sci., 2001, 12, 471–478.

16.

Shima

, Keller

J. T.

, Alvira

M. M.

, Mayfield

F. H.

and Dunsker

S. B.

: J. Neurosurg., 1979, 51, 533–538.

17.

Porter

N. L.

, Pilliar

R. M.

and Grynpas

M. D.

: J. Biomed. Mater. Res., 2001, 56, 504–515.

18.

Pilliar

R. M.

, Filiagi

M. J.

, Wells

J. D.

, Grynpas

M. D.

and Kandel

R. A.

: Biomaterials, 2001, 22, 963–1370.

19.

Holinger

J. O.

, Brekke

, Gruskin

and Lee

: Clin. Orthop., 1996, 324, 55–65.

20.

Yamaguchi

, Hirano

, Yoshida

and Iwasaki

: Biomaterials, 1995, 16, 983–985.

21.

ASTM

373–72, Annual book of ASTM standard, Vol. 15.02, 182; 1982.

22.

Jian-Jing

, Dong-Wan

and Kug-Sun

: Mater. Lett., 2004, 58, 347–351.

23.

Raynaud

, Champion

and Bernache-Assollant

: Biomaterials, 2002, 23, 1073–1080.

24.

Klein

C. P.

, van der Lubbe

, Driessen

A. A.

, de Groot

and van den Hoof

: in ‘Ceramics in surgery’, (ed. P. Vincenzini et al.), 105–114, 1983, Amsterdam, Elsevier.

25.

Vallet-Regi

and Gonzalez-Calbet

J. M.

: Sol. Stab. Chem., 2004, 32, 1–31.

26.

Wang

C. W.

, Yan

, Cang

H. C.

and Ding

S. J.

: J. Med Biol. Eng., 2003, 23, 159–164.

27.

Ducheyne

, Radin

and King

: J. Biomed. Mater. Res., 1993, 27, 25–34.

28.

Ogiso

, Yamashita

and Matsumoto

: J. Biomed Mater. Res., 1998, 39, 23–31.