Leukocyte activation is a significant component of the systemic inflammatory
response to cardiopulmonary bypass (CPB). Various strategies have been developed
aiming to reduce leukocyte activation and its deleterious effects on organ
function after cardiac surgery. Leukocyte filtration aims to physically remove
activated leukocytes from the circulation during CPB. The technique has been
used since the mid-1990s but its efficacy in attenuating the effects of
inflammatory response remains controversial. This article presents a review of
published trials investigating the effects of leukocyte filtration on humans
undergoing cardiac surgery.
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