Frequency and Markov chain analysis of amino acid sequences of mouse p53

Abstract

The amino acid sequence of mouse p53 was measured according to two-and three-amino-acid sequences. The measured frequency and probability were compared with predicted frequency and probability. Of 389 two-amino-acidsequencesinmousep53,85 (21.851%) and27 (6.941%) sequences can be explained by the predicted frequency and probability accordingto a purely random mechanism. Of 188 non-appearing two-amino-acid sequences in mouse p53, 86 (45.745%) and 32 (17.021%) can be explained by the predicted frequency and probability according to a purely random mechanism; no more than two-amino-acid sequences inmousep53 canbe explained by a purelyrandom mechanism.

Keywords

amino acid sequence mouse p53 Markov chain probability

References

1 Meek DW , Simon S , Kikkawa U , Eckhart W. The p53 tumour-suppressor protein is phosphorylated at serine 389 by casein kinase II . EMBO J. 1990; 9: 3253-3260 .

2 Samad A , Anderson CW , Carroll RB. Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells . Proc Natl Acad Sci USA. 1986; 83: 897-901 .

3 Burns PA , Kemp CJ , Gannon JV , Lane DP , Bremner R , Balmain A. Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice . Oncogene. 1991; 6: 2363-2369 .

4 Arai N , Nomura D , Yokota K , Wolf D , Brill E , Shohat O , Rotter V. Immunologically distinct p53 molecules generated by alternative splicing . Mol Cell Biol. 1986; 6: 3232-3239 .

5 Jenkins JR , Rudge K , Redmond S , Wade-Evans A. Cloning and expression analysis of full-length mouse cDNA sequences encoding the transformation associated protein p53 . Nucleic Acids Res. 1984; 12: 5609-5626 .

6 Zakut-Houri R , Oren M , Bienz B , Lavie V , Hazum S , Givol D. A single gene and a pseudogene for the cellular tumour antigen p53 . Nature. 1983; 306: 594-597 .

7 Bienz B , Zakut-Houri R , Givol D , Oren M. Analysis of the gene coding for the murine cellular tumour antigen p53 . EMBO J. 1984; 3: 2179-2183 .

8 Bairoch A , Apweiler R. The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999 . Nucleic Acids Res. 1999; 27: 49-54 .

9 Ash RB. Information Theory. Interscience, New York , 1965.

10.

10 Csiszar I , Korner J. Information Theory. Academic Press, New York , 1981.

11.

11 Feller W. An Introduction to Probability Theory and Its Applications, 3rd edn., Vol. I. John Wiley and Sons, New York , 1968.

12.

12 van der Lubbe JCA. Information Theory. Cambridge University Press, Cambridge , 1997.

13.

13 Sinkov A. Elementary Cryptanalysis-A Mathematical Approach. Mathematical Association of American, Yale University Press, New Haven , 1966.

14.

14 van Tilborg HCA. An Introduction to Cryptology. Kluwer Academic Publishers, Boston , 1989.