Congenital heart block: do fetal factors fuel the fire from inflammation to fibrosis?

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Lee LA , Reed BR , Harmon C. Autoantibodies to SS-A/Ro in congenital heart block . [abstract] Arthritis Rheum 1983; 20(suppl): S24-S24 .

Scott JS , Maddison PJ , Taylor PV , Esscher E , Scott O , Skinner RP. Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block . New Engl J Med 1983; 309: 209-212 .

Brucato A , Frassi M , Franceschini F et al. Risk of congenital congenital heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis . Arthritis Rheum 2001; 44: 1832-1835 .

Buyon, JP. Neonatal lupus syndromes. In: Lahita R (ed) Systemic Lupus Erythematosus, 4th edn. Academic Press: San Diego , 2003, in press.

Askanase A , Friedman D , Glickstein J , Kim M , Buyon J. Potential therapeutic window from normal heart rate (NHR) to advanced heart block and early detection of first degree block by echocardiographic measurement of the mechanical PR interval . [abstract] Arthritis Rheum 2002; 46(suppl): S321-S321 .

Askanase AD , Friedman DM , Dische MR et al. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies . Lupus 2003; 11: 145-151 .

Buyon JP , Clancy RM. Neonatal lupus: Review of proposed pathogenesis and clinical data from the U.S.-based Research Registry for Neonatal Lupus . Autoimmunity 2003; 36: 41-50 .

Clancy RM , Askanase AD , Kapur RP et al. Trans differentiation of cardiac fibroblasts, a fetal factor in anti-SSA/Ro-SSB/La antibody-mediated congenital heart block . J Immunol 2002; 169: 2156-2163 .

Fesslova V , Mannarino S , Salice P et al. Neonatal lupus: Fetal myocarditis progressing to atrioventricular block in triplets. A case report . Lupus 2003; 12: 415-448 .

10.

Eronen M , Siren MK , Ekblad H , Tikanoja T , Julkunen H , Paavilainen T. Short- and long-term outcome of children with congenital complete heart block diagnosed in utero or as a newborn . Pediatrics 2000; 106: 86-91 .

11.

Harley JB , Kaine JL , Fox OF , Reichlin M , Gruber B. Ro(SSA) antibody and antigen in a patient with congenital complete heart block . Arthritis Rheum 1985; 28: 1321-1325 .

12.

Lockshin MD , Bonfa E , Elkon K , Druzin ML. Neonatal risk to newborns of mothers with systemic lupus erythematosus . Arthritis Rheum 1988; 31: 697-701 .

13.

Solomon DG , Rupel A , Buyon JP. Birth order and recurrence rate in autoantibody-associated congenital heart block: implications for pathogenesis and family counseling . Lupus 2003; in press.

14.

Watson RM , Scheel JN , Petri M , Kan JS , Provost TT , Ratrie H III , Callan NA. Neonatal lupus erythematosus. Report of serological and immunogenetic studies in twins discordant for congenital heart block . Br J Dermatol 1994; 130: 342-348 .

15.

Brucato A , Gasparini M , Vignati G et al. Isolated congenital heart block: long term outcome of children and immunogenetic study . J Rheum 1995; 22: 541-543 .

16.

Kaaja R , Julkunen H , Ammala P , Kurki P , Koskimies S. Congenital heart block in one of two HLA identical twins . Eur J Obstet Gynecol Reprod Biol 1993; 51: 78-80 .

17.

Siren MK , Julkunen H , Kaaja R , Ekblad H , Koskimies S. Role of HLA in congenital heart block: susceptibility alleles in children . Lupus 1999; 8: 60-67 .

18.

Machado MVL , Tynan MJ , Curry PVL , Allan LD. Fetal complete heart block . Br Heart J 1988; 60: 512-515 .

19.

McCue CM , Mantakas ME , Tingelstad JB. Congenital heart block in newborns of mothers with connective tissue disease . Circulation 1977; 56: 82-90 .

20.

Solomon BA , Laude TA , Shalita AR. Neonatal lupus erythematosus: Discordant disease expression of U1 RNP-positive antibodies in fraternal twins - Is this a subset of neonatal lupus erythematosus or a new distinct syndrome ? J Am Acad Dermatol 1995; 32: 858-862 .

21.

Callen JP , Fowler JF , Kulick KB. Neonatal lupus erythematosus occurring in one fraternal twin . Arthritis Rheum 1985; 28: 271-275 .

22.

Lawrence N , Bligard CA , Storer J , Courrege ML. Neonatal lupus in twins . S Med J 1989; 82: 657-660 .

23.

Yazici Y , Onel K , Sammaritano L. Neonatal lupus erythematosus in triplets . J Rheumatol 2000; 27: 807-809 .

24.

Miranda-Carús ME , Dinu Askanase A , Clancy RM et al. Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of tumor necrosis factor a by macrophages . J Immunol 2000; 165: 5345-5351 .

25.

Clancy RM , Backer CB , Yin X , Kapur RP , Molad Y , Buyon JP. Cytokine polymorphisms and histologic expression in autopsy studies: Contribution of TNFa and TGFb1 to the pathogenesis of autoimmune-associated congenital heart block . J Immunol 2003; in press.

26.

Shimosegawa M , Akasaka T , Matsuta M. Neonatal lupus erythematosus occuring in identical twins . J Dermatol 1997; 24: 578-582 .

27.

Cooley HM , Keech CL , Melny BJ , Menahem S , Morahan G , Kay TW. Monozygotic twins discordant for congenital complete heart block . Arthritis Rheum 1997; 40: 381-384 .

28.

Gawkrodger DJ , Beveridge GW. Neonatal lupus erythematosus in four successive siblings born to a mother with discoid lupus erythematosus . Br J Dermatol 1984; 111: 683-687 .

29.

Glickstein JS , Buyon JP , Friedman D. The fetal PR interval: pulsed Doppler echocardiographic assessment . Am J Cardiol 2000; 86: 236-239 .

30.

Saleeb S , Copel J , Friedman D , Buyon JP. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody-associated congenital heart block: Retrospective review of the Research Registry for Neonatal Lupus . Arthritis Rheum 1999; 42: 2335-2345 .