Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis

Abstract

Lupus nephritis presents two polar histological patterns, diffuse proliferative glomerulonephritis (DPGN) and membranous glomerulonephritis (MGN). In the kidney tissue of DPGN, numerous mononuclearcells were seen in the interstitium and glomeruli; on the other hand in MGN, infiltrating cells were less frequent. Monocyte chemoattractantprotein-1 (MCP-1) is a potent chemoattractantfor monocytes, T-cells, and natural killer cells. In this study we assessed the significance of the MCP-1 gene in determination of the histological phenotype in lupus nephritis. There was no association between the risk of DPGN and the MCP-1 gene genotype.

Keywords

gene polymorphism membranous glomerulonephritis (WHO class V)MCP-1 proliferative glomerulonephritis (WHO class IV)SLE

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References

Klinman DM , Steinberg AD. Inquiry into murine and human lupus . Immunol Rev 1995; 144: 157-193 .

Theofilopoulos AN , Dixon FJ. Murine models of systemic lupus erythematosus . Adv Immunol 1985; 37: 269-390 .

Dixon FJ. The pathogenesis of glomerulonephritis . Am J Med 1968; 44: 493-498 .

Chrug J , Berntein J , Glasock RJ. Lupus nephritis. In Chrug J , Berntein J , Glasock RJ eds. Renal diseases: classification and atlas of glomerular disease. New York: Igaku-Shoin , 1995; 151-180.

Kashgarian M. Lupus nephritis: pathology, pathogenesis, clinical correlations, and prognosis. In Wallace DT , Hahn BH eds. Dubois’ lupus erythematosus, 5th edition. Philadelphia: Williams and Willkins , 1997; 1037-1051.

Masutani K , Akahoshi M , Ninomiya T et al. Predominance of Th1 type immune responses in human diffuse proliferative lupus nephritis . Arthritis Rheum 2001; 44: 2097-2106 .

Valente AJ , Graves DT , Vialle-Valentin, CE , Delgado R , Schwartz CJ. Purification of monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture . Biochemistry 1988; 27: 4162-4168 .

Carr MW , Roth SJ , Luther E , Rose SS , Springer TA. Monocyte chemoattractant protein-1 acts as a T-lymphocyte chemoattractant . Proc Natl Acad Sci USA 1994; 91: 3652-3656 .

Allavena P , Bianchi G , Zhou D et al. Induction of natural killer cell migration by monocyte chemotactic protein-1, -2 and -3 . Eur J Immunol 1994; 24: 3233-3236 .

10.

Segerer S , Nelson PJ , Schlondorff D. Chemokines, chemokinereceptors, and renal disease: from basic science to pathophysiologic and therapeutic studies . J Am Soc Nephrol 2000; 11: 152-176 .

11.

Rovin BH , Rumancik M , Tan L , Dickerson J. Glomerular expression of monocyte chemoattractant protein-1 in experimental and human glomerulonephritis . Lab Invest 1994; 71: 536-542 .

12.

Wada T , Yokoyama H , Su SB et al. Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis . Kidney Int 1996; 49: 761-767 .

13.

Wada T , Furuichi K , Segawa-Takaeda C et al. MIP-1alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis . Kidney Int 1999; 56: 995-1003 .

14.

Rovin BH , Phan LT. Chemotactic factors and renal inflammation . Am J Kidney Dis 1998; 31: 1065-1084 .

15.

Zoja C , Liu XH , Donadelli R et al.

Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice

J Am Soc Nephrol 1997; 8: 720-729 .

16.

Rovin BH , Doe N , Tan LC. Monocyte chemoattractant protein-1 levels in patients with glomerular disease . Am J Kidney Dis 1996; 27: 640-646 .

17.

Noris M , Bernasconi S , Casiraghi F et al. Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis . Lab Invest 1995; 73: 804-809 .

18.

Saitoh A , Suzuki Y , Takeda M , Kubota K , Itoh K , Tomino Y. Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy . J Clin Lab Anal 1989; 3: 355-359 .

19.

Gong JH , Ratkay LG , Waterfield JD , Clark-Lewis I. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model . J Exp Med 1997; 186: 131-137 .

20.

Tesch GH , Maifert S , Schwarting A , Rollins BJ , Kelley VR. Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas lpr mice . J Exp Med 1999; 190: 1813-1824 .

21.

Rovin BH , Lu L , Saxena R. A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression . Biochem Biophys Res Commun 1999; 259: 344-348 .

22.

Rovin BH , Phan LT. Chemotactic factors and renal inflammation . Am J Kidney Dis 1998; 31: 1065-1084 .

23.

Strieter RM , Koch AE , Antony VB , Fick RB Jr , Standiford TJ , Kunkel SL. The immunopathology of chemotactic cytokines: the role of interleukin-8 and monocyte chemoattractant protein-1 . J Lab Clin Med 1994; 123: 183-197 .

24.

Antoniades HN , Neville-Golden J , Galanopoulos T , Kradin RL , Valente AJ , Graves DT. Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis . Proc Natl Acad Sci USA 1992; 89: 5371-5375 .

25.

Koch AE , Kunkel SL , Harlow LA et al. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis . J Clin Invest 1992; 90: 772-779 .

26.

Grandaliano G , Gesualdo L , Ranieri E et al. Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: a pathogenetic role in interstitial monocytes recruitment . J Am Soc Nephrol 1996; 7: 906-913 .